Multiple Dose Regimen Part 2

Question 1

What are the two method employed to alter steady-state concentrations?

Answer 1

Change the drug dose and maintain the same dosing interval.

Change the dosing interval and maintain the same drug dose.

Question 2

What does increasing the dose change?

Answer 2

Increases stead-state concentrations
increases fluctuations between peak to trough concentrations
Usually no change in patient compliance

Question 3

What does decreasing the dose change?

Answer 3

Decreases steady-state concentrations
decreases fluctuations between peak to trough concentrations
usually no change in patient compliance

Question 4

What does superposition assume?

Answer 4

That early doses of drug do not affect the pharmacokinetics of subsequent doses

Question 5

What parameters can be adjusted in developing a dosage regimen?

Answer 5

dose and dose frequency