Modified Release Flashcards
What are products that alter the timing and/or the rate of release of drug?
Extended-Release Delayed-Release Targeted-Release Orally Disintegrating Tablets Controlled Release Enteric coatings Repeat action Prolonged action Sustained release
How does sustained release usually work?
The first dose is a loading dose and the remaining drug is released over time.
How does sustained release compare to rapid release?
Tmax is usually longer
Cmax is usually reduced
AUC is constant
What are the biopharmaceutic factors of the stomach?
physiologic state
pH
emptying-rate
mixing action
What are the biopharmaceutic factors of the small intestine?
transit time
surface area
What are the biopharmaceutic factors of the large intestine?
drug transit
presence of fluid
The amount of drug required in an extended-release dosage form to provide a sustained drug level in the body is determined by the:
pharmacokinetics of the drug
desired therapeutic level of the drug
intended duration of action
What is the total dose required?
the sum of the maintenance dose and the initial dose released immediately to provide a therapeutic blood level.
If there is no built-in loading dose, the dose needed to maintain a therapeutic concentration for hours is:
Do = CpCltT
