Muerte celular Flashcards

1
Q

Apoptosis

A

Morte celular programada
solo una celula
Generalemente fisiologica
No genera inflamación

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2
Q

Ativación de caspasas

A

Por via mitocondrial (intrinseca) -> Producción de citocromo c -> ativa caspasas -> fragmenta ADN

Por via da muerte (extrinseca) -> Receptor TNF -> ativa proteinas adaptadoras -> ativa caspasas -> fragmenta ADN

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3
Q

Necrosis

A

Muerte celular masiva
Patologica
consecuencia de lesíon progresiva
Inflamacíon

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4
Q

Tipos de necrosis

A

Necrosis coagulativa
Necrosis licuefativa
Necrosis caseosa
Necrosis Grasa
Necrosis fibrinoide
Necrosis grangrenosa

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5
Q

Necrosis coagulativa

A

Necrosis isquemica (infarto)
celula conversa forma
Desnaturalização proteínas
reclutan leucocitos
2 tipos : Anemia (blanca) : oclusión arterial
Hemorragica(rojo) : reperfusión o torsión

Ej: Infarto agudo do miocardio

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6
Q

Necrosis licuefativa

A

Pus -> quando tem bacteria
Celula perde a forma
Autolisis
Semi- liquida o pastosa

EJ: Infarto cerebral
Abcesos (exudado)

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7
Q

Necrosis caseosa

A

Bacilo de koch (Tuberculosis)
Queso ricota ( blanco amarillento)
Macrofagos y linfocitos
Gramunola
Acumulación de celulas fragmentadas

Ej : tuberculosis

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8
Q

Necrosis grasa

A

2 tipos : enzimatico e traumatico
Liberación lipasas
formación de jabones calcicos

Ej: pancreatitis

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9
Q

Necrosis fibrinoide

A

Reaccion inmunitarias ( hipersensibilidad 3)
complejo antigeno-anticuerpo
se ve parecido a fibrina

ej: vasculitis

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10
Q

Necrosis gangrenosa

A

Necrosis insquemica en territorio arterial terminal

3 tipos:
* seca -> sin infeción bacteriana
tejido disecado / negruzco - ej : frio

  • Humeda - con bacteria
    rojizo amarillento
    ej: diabetes

*caseosa - similar a humeda (germen clostridios)
Profuce burbujas
olor podrido

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