MSRA: Cystic Fibrosis

Question 1

What are the genetics of cystic fibrosis?

Answer 1

Autosomal recessive inheritance
White Caucasian 1 in 25 carrier rate
CTFR gene on chromosome 7
Thick sticky secretions
Organs affected: lungs, pancreas, sweat glands, bowels, reproductive tract

Question 2

How does cystic fibrosis lead to infertility?

Answer 2

Women - thickened cervical mucus
Men - congenital bilateral absence of vas deferens