MSRA: Anti-Psychotics

Question 1

What are the side effects of anti-psychotics?

Answer 1

Weight gain
EPSEs
Impaired glucose tolerance
Raised prolactin

Question 2

What are the side effects of Clozapine?

Answer 2

Agranulocytosis
Myocarditis
Reduced seizure threshold

Question 3

What monitoring is required for anti-pyschotics?

Answer 3

Prolactin and glucose: 6 months and yearly
FBC, U+Es, LFTs every 12 months
BMI weekly for the firtst 6 weeks, then at 3 months and then every 12 months
Lipids at 3 months then yearly

Question 4

What are the extra-pyramidal side effects?

Answer 4

Acute dystonia: muscle spasms
Akathisia: restlessness
Parkinsonism
Tardive dyskinesia: involuntary movements of face

Question 5

What are the features of neuroleptic malignant sydrome?

Answer 5

Temperature
Muscle rigidity
Tachycardia, hypertension
Confusion

Question 6

How is Clozapine monitored for agranulocytosis?

Answer 6

FBC weekly for 18 weeks
Then fortnightly for up to one year
Then monthly

Question 7

Oculogyric crisis is an example of which extra-pyramidal side effect?

Answer 7

Acute dystonia

Question 8

Which medication is first line for rapid tranquilisation?

Answer 8

Lorazepam