Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

DOOS2-FINAL > MSK2 > Flashcards

MSK2 Flashcards

1
Q

What is systemic lupus erythematosus (SLE)?

A

A multisystem autoimmune connective tissue disease characterized by the presence of numerous autoantigens, autoantibodies, and circulating immune complexes with widespread immunologically determined tissue damage

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

What pt populations does SLE more frequently affect?

A

Non-white, AA more susceptible with severe disease, 90% female of child bearing age

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

When is SLE most frequently diagnosed?

A

Between 15-45 years old

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

What causes early death in SLE?

A

Active lupus and infection

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

What causes late deaths in SLE?

A

Sequelae of chronic lupus, chronic medications, CVD, infections

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

What is the most likely pathogenesis of SLE?

A

Likely genetic component in the setting of immune dysregulation, environment, and hormonal triggers

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

What environmental triggers are implied with SLE?

A

UV lights, microorganisms, tobacco, others

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

What are the 2 ways SLE autoantibodies cause tissue injury?

A

1) Formation of immune complexes and depostition of Ig at dermal- epidermal jxn and in renal tissue
2) damage or destruction of specific cells causing inflammation, activated PMNs, and release of oxygen radicals and lysozymes that damage and destroy tissues

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

What drugs can induce SLE?

A

Procainamide, hydralazine, isoniazid, methyldopa, quinidine, chlorpromazine, phenothiazines, OCPs, anticonvulsants

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

What are the clinical features of SLE?

A

Arthritis, arthralgia, and fever

Specifically polyarthralgia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

What is the most common constitutional symptom in SLE?

A

Fatigue, occurs in >90%

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

What is the onset of symptoms like?

A

Gradual onset with flares and remission

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

What can happen with pregnancy and SLE?

A

May onset during pregnancy and may be present in women with hx of spontaneous abortion
Babies SGA

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

What vascular condition is common in SLE?

A

Raynauds

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

2/3 of pts with SLE have what?

A

Skin signs- lupus dermatitis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

How might the skin conditions present?

A

vasculitis, purpura or periungual erythema. Classic malar butterfly rash and discoid lesions

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

What CNS manifestations present in SE?

A

Epilepsy, depression, dementia, psychosis, hemiplegia, chorea, ataxia, pripheral neuropathy

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

What are abdominal manifestations in SLE?

A

Ab pain, peritonitis, splenomegaly, pancreatitis, GI ulcers

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

What are ocular manifestations in SLE?

A

Keratoconjunctivitis, episcleritis, retinal vasculitis & retinal exudates

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

What is diagnostic criteria for SLE?

A

4 or more of the following during the course of the disease:
-—Malar Rash —Oral Ulcers
—Arthritis
—Serositis (heart/lungs)
—Renal Disease (proteinuria, cellular casts)
—Hematologic Disorders (hemolytic anemia, leukopenia, lymphopenia, thrombocytopenia)
—Immune Disorders (including false + syphilis)
—Neurological Disorders (sz., psychosis)
—Discoid Rash
—Photosensitivity
—+ANA

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

what immunologic criteria is most common in lupus?

A

Positive ANA

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

How should SLE be managed?

A

REFER

- NSAIDS, exercise, sun protection, smocking cessation, antimalarials, corticosteroids

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
23
Q

What is the mainstay tx for SLE and what needs to be monitored?

A

Antimalarials - Watch for retinal toxicity

- baseline and annual eye exams with visual field testing

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
24
Q

When are corticosteroids mainstay?

A

If antimalarials are insufficient

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
25
Q

What corticosteroid combo is superior for preventing renal failure in SLE?

A

Prednisone + cyclophosphamide

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
26
Q

What should be used to tx SLE in pregnancy?

A

hydroxychloroquine and prednisone/prednisolone

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
27
Q

What comorbid conditions are associated with SLE that need to be assessed for and tx?

A
  • -Accelerated atherosclerosis
  • -Pulmonary hypertension
  • -Antiphospholipid syndrome
  • -Osteopenia or osteoporosis
  • -Non-Hodgkin lymphoma
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
28
Q

What preventative measures can be taken with SLE?

A

—Sun protection (clothing and sunscreen)
—Vaccination (influenza and pneumococcal)
—Caution with live-attenuated vaccines and immunosuppression
—Suppress recurrent infections (UTIs)
—Prevent osteoporosis (steroids)
—Prevent and control CVD and obesity

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
29
Q

What are the general characteristics of sjogrens syndrome?

A

Autoimmune disorder causing destruction of salivary and lacrimal glands- exocrine

30
Q

What is the most common pt population for sjogrens syndrome?

A

Most common in middle aged females (9:1 ratio female: male)

31
Q

What is the pathophys involved in sjogrens?

A

B lymphocyte hyperactivity
Infiltration of the exocrine glands by lymphocytes, resulting in inflammation and destruction of tissue
Infiltration of viscera and skin leading to extrglandular conditions

32
Q

What are the cardinal clinical features of sjogrens?

A

Exocrine malfunction: dry mouth, dry eyes, enlargement of the parotid glands
Constitutional: fatigue, fever, wt loss, lymphadenopathy
Extraglandular: articular and raynaud phenomenon, B cell lymphomas

33
Q

What is the diagnostic criteria for sjogrens?

A

4 of 6 of the following or 3 or 4 of the objective criteria ( III, IV, V, VI)
I. Ocular symptoms
II. Oral symptoms (dry mouth, swollen glands)
III. Ocular signs (Shirmer’s test, Rose Bengal)
IV. Histopathology (biopsy minor salivary glands)
V. Salivary gland testing
VI. Reactive antibodies to RO/SS-A or La/SS-B

34
Q

What are other tests that can be done to diagnose sjogrens?

A

Shirmers test- evaluates tear secretions, less than 5mm in 5 min is positive
Corneal abrasion- stain with slip lamp evalv
Biopsy of lower lip mucosa- confirms lymphocytic infiltrate gland fibrosis

35
Q

What is the treatment of sjogrens?

A

Symptomatic tx- artificial tears and saliva, ocular and vaginal lubricants, oral lubricants ,Protect eyes, Increase PO intake
NSAID- for arthralgia
Antimalarials/ methotrexate- 1st line for extraglandular
Nifedipine and prostacycline for raynauds
ACEI for HTN

36
Q

What is systemic sclerosis (scleroderma)?

A

Multi-system autoimmune dz of unknown cause with chronic and progressive features

37
Q

What is the hallmark of scleroderma?

A

Vasculopathy and excess collagen deposits

38
Q

What does scleroderma lead to?

A

Fibrosis and degenerative changes of skin and internal organs
Ulcerations, ischemia, atrophy and gangrene of the skin and digits

39
Q

What are early manifestations of scleroderma?

A

Raynauds and skin calcinosis

Wrist pain, wheezing, skin pigments, joint pain, hair loss and alopecia, eye burning itching or discharge

40
Q

When it the typical age of onset in scleroderma?

A

30-50

41
Q

What gender is most affected by scleroderma?

A

Females… 4.6: 1 ratio

42
Q

What are the 2 types of systemic sclerosis?

A

Diffuse cutaneous

Limited cutaneous- crest syndrome

43
Q

What does diffuse typically affect?

A

Skin, heart, lungs, GI tract, and kidneys

Typically worse!

44
Q

What does crest syndrome affect?

A

Skin of the face, neck, elbows, knees
In late stages it may cause isolated pulmonary HTN
Raynauds associated with critical ischemia of the digits

45
Q

What are the cardinal clinical features of scleroderma?

A

Skin – most begin with swelling in the fingers and hands, may spread to the trunk or the face
Raynauds
Polyarthralgias and esophageal dysfxn
Tendon or bursal friction rubs often seen prior to thickening of the skin

46
Q

What are the systemic and MSK changes in scleroderma?

A

Arthritis, arthralgia, crepitus of tendon sheaths, non-progressive myopathy with weakness and atrophy

47
Q

What are the skin changes in systemic sclerosis?

A

Non pitting edema- “sausage” swelling of fingers
Skin shiny and atrophied with fingertip ulcers
Decreased facial pigment and presence of telangiectasias
Tightening over bony prominences
Flexion contractures
Loss of adipose tissues
Symmetric and bilateral skin changes

48
Q

What is the hallmark skin change in crest?

A

Telangiectasias

49
Q

What is the mneumonic for CREST?

A 
Calcinosis
Raynauds
Esophageal dysfxn
Sclerodactyly
Telangiectasias
50
Q

What are GI changes associated with Systemic sclerosis?

A

Reflux esophagitis, hiatal hernia, loss of normal peristalsis, dilatation of large and small bowel, pain, constipation, diarrhea, primary biliary cirrhosis

51
Q

What are some complications of scleroderma?

A

Cardiac failure, renal failure (emergency), pulmonary fibrosis, R heart failure, malabsorption, malnutrition, osteoporosis

52
Q

How is scleroderma diagnosed?

A

Primarily a clinic diagnosis

53
Q

Can scleroderma be cured?

A

No, only supportive and organ specific tx

54
Q

What are the organ specific tx for scleroderma?

A

Antihistamines and low-dose steroids for early skin involvement
PPI for GERD
ACEI for Renal
Ca+ Channel Blockers or ARBs for Raynaud’s
Bosentan or sildenafil for pulmonary HTN
PT with daily stretching to avoid contracture

55
Q

What is polymyalgia rheumatica?

A

inflammatory rheumatic condition characterized clinically by aching and morning stiffness in the shoulders, hip girdle, neck, and torso

56
Q

What are 15% of pts with PMR also diagnosed with?

A

Temporal arteritis ( GCA)- complication is blindness

57
Q

What gender is more commonly affected?

A

Female >male, 2-3:1

58
Q

What is the typical pt population?

A

Female, northern European, age around 50 but peaks 70-80

59
Q

What gene is PMR associated with?

A

HLA_DR4

60
Q

What are the cardinal clinical features of PMR?

A 
Stiffness is predominant symptom in shoulders, hip girdle, neck, and torso 
÷Most severe after rest and in the AM
÷Stiffness may last more than 30 minutes
÷Bilateral, proximal, symmetrical
÷Onset may be abrupt
61
Q

What are other symptoms of PMR?

A

systemic malaise, fatigue, depression, anorexia, weight loss, and low-grade fever

62
Q

How is PMR diagnosed?

A

Empirical criteria:

  • Age >50 at onset
  • Proximally and bilaterally distributed aching and morning stiffness (lasting at least 30 minutes or more) persisting for at least two weeks. The stiffness should involve at least two of the following three areas: neck or torso, shoulders or proximal regions of the arms, and hips or proximal aspects of the thighs
  • Erythrocyte sedimentation rate (ESR) ≥40 mm/hr
  • Rapid resolution of symptoms with low-dose glucocorticoids. Symptoms are generally 50 to 70 percent better within three days in patients with PMR started on prednisone at a dose of 10 to 20 mg/day. The lack of response to initial therapy strongly suggests an alternative diagnosis
63
Q

What MUST you assess for if your pt is diagnosed with PMR?

A

GCA- >50, fever, elevated ERS, anemia with temporal artery tenderness, HA

64
Q

How is PMR treated?

A

Low dose corticosteroid therapy

  • Prednisone 15mg PO Qday
  • may need for up t 2 years
  • higher dose plus ASA is GCA
65
Q

What is fibromyalgia?

A

A controversial chronic pain syndrome characterized by persistent, widespread pain and tenderness to palpation at defined tender points in soft tissue structures

66
Q

What is the prevalence of fibromyalgia?

A

Female : male = 9:1 ration

67
Q

How is fibromyalgia diagnosed?

A

Diagnosis of exclusion

r/o: inflammatory disorders and thyroid by obtaining CBC, ESR, CRP, and TSH

68
Q

What is fibromyalgia strongly associated with?

A

Mood disorders

69
Q

What are the cardinal clinical features of fibromyalgia?

A
  • -Non-articular, diffuse and poorly localized musculoskeletal pain, usually accompanied by fatigue and sleep disturbance- “Pain all over!”
  • –Diffuse tenderness on exam
  • —constellation of additional symptoms- fatigue, stiffness, poor sleep, panic disorder, depression, HA/ “migraine”, irritable bowel, dysmenorrhea, and parasthesias may be seen
70
Q

Are narcotics indicated for tx of fibromyalgia?

A

NO

71
Q

How is fibromyalgia managed?

A

—Amytriptyline 10mg 1-3 hours prior to bed, titrate to 25-50mg
—Cyclobenzaprine is an alternative
SNRIs may be helpful if fatigue is severe
—Anti-convulsants- gabapentin and pregabalin (for sleep disturbance and pain)
—Pregabalin dose- 25-50mg PO QHS and titrate up to 300-450mg QDAY
Aerobic exercise to improve conditioning is very important
— education and psych counseling

DOOS2-FINAL (8 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions