MSK & Rheumatology Flashcards
1
Q
What is bone structure made up of?
A
1) Cortical bone outside (arranged in osteon functional units) 2) Trabecular bone inside
2
Q
Structure of osteons?
A
Made up of concentric lemellae (like a tree trunk) and central Haversian canal - Haversian canal supplies a single longitudinal osteon - horizontal communication between osteons = volkmann canals
3
Q
Component of bone? (Inorganic and organic)
A
Inorganic component = hydroxyapatite (Ca2(PO4)3) - stiffness Origanum component = collagen T1 - elasticity
4
Q
Purpose of trabecular bone?
A
Bone marrow structural meshwork Low in mass but high in strength
5
Q
Three types of joints?
A
1) Fibrous (synarthrosis, unmovable) - skull sutures 2) Cartilaginous (amphiarthrosis, partially moveable) - IV disc, pubic symphysis 4) Synovial (diarthrosis, freely moveable) - most joints of body (knee, hip, shoulder etc)
6
Q
Synovial joint components?
A
- articular cartilage - joint capsule (inner lining = synovial membrane) - synovial cavity filled with little synovial fluid
7
Q
Attachment from bone to bone?
A
Ligaments
8
Q
Attachment from muscle to bone?
A
Tendons
9
Q
Most common type of arthritis?
A
Osteoarthritis
10
Q
What is osteoarthritis?
A
- Traditionally a “non-inflammatory” age-related “degenerative” joint disorder characterised by joint pain and functional limitation. - No longer thought to be the case as it is shown to be inflammatory too. - Metabolically active and dynamic process that is mediated by cytokines. - Often symmetrical and bilateral
11
Q
What joints does osteoarthritis typically affect?
A
Knees Hips Hands Spine (cervical and lumbar) Base of thumb pain pain almost ALWAYS osteoarthritis
12
Q
Non modifiable risk factors for osteoarthritis?
A
- Age (50+) - uncommon in those under 45 - Females (hip OA is twice as common in women than men) - Genetics (COL2A1= predisposition) - more common when it presents bilaterally - High bone density - but actually protective against osteoporosis - abnormal biomechanics - joint hypermobility or congenital hip dysplasia
13
Q
Modifiable risk factors for osteoarthritis?
A
- obesity (3x increased risk) as it is a low grade inflammatory state with release of cytokines - joint injury and damage (history of inflammation can increase risk) - Exercise stresses (occupation with lots of standing or professional athletes) footballers more likely to have osteoarthritis of knees and those with lots of manual labour more likely to have osteoarthritis in the hands
14
Q
Aetiology of osteoarthritis?
A
Imbalance between extracellular matrix synthesis vs degradation regulated by chondrocytes within the cartilage => loss of cartilage, remodelling of adjacent bone and subsequent inflammation
15
Q
Pathophysiology of osteoarthritis?
A
Increased metalloproteinase secretion by chrondocytes which degrades T2 collagen and causes cysts - bone attempts to overcome this with T1 collagen leading to abnormal bony growths (osteophytes) + remodelling
16
Q
Symptoms of osteoarthritis?
A
- Transient morning pain (<30min) - joint pain exacerbated by movement and gets worse as the day goes on - swelling - joint locking (particularly common at the knee) - functional impairment such as walking or activities of daily living
17
Q
Signs of osteoarthritis in the hands?
A
Haberden’s nodes: asymmetrical bony swelling at the distal interphalangeal joint -Bouchard’s nodes: asymmetrical bony swelling at proximal interpharangeal joint (also seen in RA) -Thenar wasting -First carpometacarpal joint: most typically affected as most stressed
18
Q
Sign of osteoarthritis in the knee?
A
Crepitus: crackeling or grating sensation when moving a joint
19
Q
Signs of osteoarthritis in the hips?
A
Antalgic gait: patients may walk with a limp Restricted internal rotation: when hip flexed
20
Q
Investigations to diagnose osteoarthritis?
A
joint x-rays: LOSS LOSS of joint space osteophytes Subchondral cysts Subchondral sclerosis -bloods will be normal with no inflammatory markers
21
Q
Treatment of osteoarthritis?
A
img
22
Q
Complications of Osteoarthritis?
A
Biopsychosocial: NSAID complications Low mood Chronic pain Fictional decline in activities of daily living
23
Q
What is rheumatoid arthritis?
A
Chronic, systemic inflammatory disease => deforming, symmetrical inflammatory arthritis of the small joints and progresses to involve larger joints and other organs
24
Q
Genetic risk factors for rheumatoid arthritis?
A
HLA-DR1 and DR4 are crucial in activating t-cells -PTPN22 also implicated
25
Environmental triggers for rheumatoid arthritis
Smoking
26
Epidemiology of rheumatoid arthritis?
Age- peak onset = 30-50 years of age Females (2-4x more common) Prevalence is 1% in the UK
27
Pathophysiology of rheumatoid arthritis?
- arginine -> citrulune mutation in T2 collagen causes anti - CCP (cyclic citrulinated peptide) formation - IFN -a catses further pro inflammatory recruitment to synovium - synovial lining expands and tumour like mass “pannus” grows past joint margins - pannus destroys Subchondral bone and articulatar cartilage
28
Symptoms of rheumatoid arthritis?
Often worse in the morning (~30mins) eases as day goes on - often struggle to make a tight fist
29
Signs of rheumatoid arthritis?
1) Boutonnière deformity (PIP flexion and DIP hyperextension) 3) swan-kneck deformity (PIP hypertension and DIP flexion) 4) z-thumb deformity (hypertensions of the thumb IP joint with flexion of MCP joint) 5) ulnar deviation of fingers - usually symmetrical and DIPs are spared
30
How to differentiate psoriatic arthritis from rheumatoid arthritis?
DIP joints often spared in rheumatoid arthritis but affected in psoriatic arthritis
31
What is felty syndrome?
Triad of: 1) rheumatoid arthritis 2) granulocytopejia 4) splenomegaly = life threatening risk of infection
32
Extra-articular complications for rheumatoid arthritis?
Lungs - Pericardial effusion, pulmonary fibrosis - Heart - Increased IHD risk - Eyes - episcleritis, keratoconjuctivitis sicca (dry Eyes) - spinal cord compression - kidney (CKD) - rheumatoid skin nodules (often at elbows) - peripheral sensory neuropathy
33
Investigations to diagnose rheumatoid arthritis?
BLOODS: Increased ESR/CRP (used to monitor disease progression), normocytic normochromic anaemia (mc) SEROLOGY: +ve anti CCP (80% specific), +ve RF (70% non specific) X-RAY: LESS - Loss of joint space - Eroded bone - Soft tissue swelling - Soft bones (osteopenia)
34
Treatment for rheumatoid arthritis?
1) DMARD- methotrexate (CI in pregnancy as it is a folate inhibitor) => DNA synthesis affected - gold standard and often give with biologic 2) BIOLOGICS (v good but expensive) -1st line (given with methotrexate) = TNF-d inhibitor INFLIXIMAB or ETANERCEPT -2nd line = b cell inhibitor (CD20 target) - RITUXIMAB Referral to physio, OT, podiatry as indicated
35
What is gout caused by?
Hyperuricemia which results in sodium urate crystal deposition along joints + intrarticularly (inside entry to joint)
36
Most common inflammatory arthritis in the uk?
Gout
37
What is an arthroplasty?
surgical reconstruction or replacement of joint
38
What are crystalline arthropathies?
Group of joint disorders caused by deposits of crystals in joints and the soft tissues around them
39
How does gout typically present?
Middle aged overweight men who drink a lot of BEER
40
Risk factors for Gout?
Purine rich foods i.e meat, seafood, beer - CKD - Diuretics
41
Food group that can be anti-gout?
Dairy
42
Pathophysiology of gout?
Underlying hyperuricaemia Uricase not found in humans so uric acid is insoluble Hence USIC acid deposits in joints causing symptoms
43
Symptoms of Gout?
Monoarthritis; -Typically BIG TOE (metatarsophalangeal joint) PODAGRA -Sudden onset -Severe swollen red toe -Can't put weight on it -Low grade fever Onset is typically at night
44
Differential diagnosis for gout?
Septic arthritis but this typically affects the knee rather than big toe Trauma Rheumatoid arthritis
45
Does hyperuricemia guarantee gout?
No it increases gout risk
46
Investigations to diagnose gout?
- measure serum urate level to see if there's hyperuricemia - if not high but still suspected, repeat in 2-4 weeks Gold standard: (if still unsure) - Joint aspiration and light microscopy of synovial fluid
47
Treatment for acute gout?
-Change diet: decrease purines and increase dairy intake -NSAIDs -> colchine -> prednisolone Don’t use nsaids if they have renal failure, peptic ulcer disease or some pts with asthma and reduce colchine dose for patients with renal failure
48
Prophylactic/long term treatment for gout?
PREVENTION: (after several attacks) Allopurinol as part of Urate Lowering Therapy (ULT) = xanthine oxidase inhibitor - decreases uric acid production - target uric acid <360 mmol/l If that doesn’t work due to intolerance or inefficacy can use febuxostat Plus colchicine 500 micrograms OD for up to 6 months for gout prophylaxis
49
What is Pseudogout?
Calcium pyrophosphate (not sodium urate) crystals deposit along joint capsule
50
Typical presentation of pseudogout?
Elderly female, 70+
51
Risk factors for pseudogout?
Diabetes -Metabolic diseases -Osteoarthritis
52
Symptoms of pseudogout?
Often polyarticular with knee commonly involved = Swollen, hot, red joint
53
Differential diagnosis of pseudogout?
Sceptic arthritis as both effect the knee
54
Investigations to diagnose Pseudogout?
Aspirate joint and analyse sample with polarised light microscopy = gold standard - chrondocalcinosis on x ray
55
Light microscopy results with pseudogout?
Positively birefringent, rhomboid shaped crystals
56
Light microscopy results of gout?
Negatively birefringent needle shaped crystals
57
Treatment for pseudogout?
Only acute management: NSAIDS --> colchicine-->steroid injections
58
What is osteoporosis?
Decreased bone density by 2.5+ SDs below young adult mean value (T<2.5) Systemic skeletal disease characterised by low bone mass and micro architectural deterioration of bone tissue, with a consequent increase in bone fragility and susceptibility to fracture.
59
What is a decrease in bone mineralisation known as?
Osteomalacia
60
Typical patient presentation of osteoporosis?
50+ postmenopausal Caucasian women
61
Risk factors for osteoporosis
SHATTERED -Steroids -Hyperthyroid/Hyperparathyroid -Alcohol+smoking -Thin (decreased BMI) -Testerone (decreased) -Early menopause (decreased oestrogen) -Renal / liver failure -Erosive + inflammatory disease -DMT1 or malabsorption
62
What is T-Score?
Standard deviations from gender-matched young adult mean > -1 Normal -1 to -2.5 Osteopenia (precursor) < -2.5 Osteoporosis < -2.5 plus fracture is severe osteoporosis
63
Symptoms of Osteoporosis?
Only Fractures: 1) Proximal femur (falls) 2) Collles' (forked wrist - fall on outstretched wrist) 3) Compression vertebral crush (may cause kyphosis "widows stoop")
64
Investigations to diagnose osteoporosis?
Dexa scan (gold standard) = Dual energy XR absorptiometry; yields T score by comparing patient BMD to reference Also use FRAX score (fracture risk assessment tool in osteoporotic patients)
65
Treatment for osteoporosis?
1) FIRST LINE: = bisphosphonates (osteoclast inhibitors) eg. aldrenoate, risedronate which inhibits RANK-L signalling =CHEAP + EFFECTIVE 2) SECOND LINE: -mAB denosumab (inhibits RANK L) -HRT (testosterone, oestrogen) -Recombinant PTH - Teriparatide -Oestrogen receptor modulator - raloxifene
66
What is systemic lupus erythmatosus? (SLE)
Hypersensitivity T3 reaction (A-A complex depositon) = autoimmune systemic inflammation
67
Who does SLE typically effect?
-Females -Afro Caribbean -20-40 (premenopausal)
68
Risk factors for SLE?
-Female (12x more than males) (90% are women) -HLAB8/DR2/DR3 + low C4 (null allele) -drugs (isoniazid)
69
Pathophysiology of SLE?
Impaired apoptotic debris presented to TH cells -> B cell activation -> antigen-antibody complexes
70
Symptoms of SLE?
-butterfly rash -photosensitivity -glomerulonephritis -seizures + psychosis -mouth ulcers -anamia -joint pain -raynauds -pyrexia -serositis (pleural/pericardial inflammation of lungs) -pericarditis
71
Investigations to diagnose SLE?
-Bloods -> anaemia -Increase ESR + normal CRP -Urine dipstick -> haematuria++++ proteinuria++ (NephrItic syndrome) -Serology: -ANA Abs (99% of cases) -Anti ds DNA Ab's (to monitor progression) -Decreased C3+C4
72
Which combination of v. specific and v. sensitive tests are used as essentially diagnostic for SLE?
img
73
Treatment of SLE?
-Lifestyle changes (less sunlight or UV protection + stop the triggering drugs) - Drugs: 1) Corticosteroids (main) 2) + hydroxychloroquinine 3) + NSAIDS (+ azathioprine, mycophenolate if severe (cytotoxic)) - even biologically like rituximab if they don’t work - if patient exhausts all treatment options they can be considered for stem cell transplant
74
Treatment for SLE once stable?
Aim to taper off other drugs leaving only hydroxychloroquine
75
What is antiphospholipid syndrome characterised by?
Thrombosis -Recurrent miscarriage -aPL Abs
76
Presentation of antiphospholipid syndrome?
Can be primary (idiopathic) or secondary (to other diseases, especially SLE) -Higher risk in Females
77
Symptoms of antiphospholipid syndrome?
CLOTS Coagulopathy Livedo reticularis (purple discolouration of skin, lace-like) Obstetric issues - miscarriages Thrombocytopenia + Higher risk of arterial (stroke, MI) + venous thrombosis (DVT)
78
Investigations to diagnose antiphospholipid syndrome?
1) lupus anticoagulant 2) Anti cardiolipin antibodies (IgG/M) +ve 3) Anti beta-2 glycoprotein-1 antibodies
79
Treatment for antiphospholipid syndrome?
1st line = warfarin long term if have had a thrombosis * if pregnant give aspirin + heparin
80
Prophylactic treatment for antiphospholipid syndrome?
If not had a thrombosis = ASPIRIN
81
What is sjogrens syndrome?
An autoimmune exocrine dysfunction DRY!!!
82
Typical presentation and risk factors of Sjogren syndrome?
-Can be primary or secondary to other autoimmune diseases - Females (40-50) - fHx - HLAB8/DR3
83
Symptoms of Sjogren syndrome?
1) Dry eyes (keatoconjuctivitis sicca) 2) Dry mouth (xerostoma) 3) Dry vagina
84
Complication/association of Sjogrens?
Directly confers an increase risk of lymphomas
85
Investigations to diagnose Sjogren syndrome?
Serology = anti-RO + anti LA Ab's (ANA often +ve) Schrimer test = induce tears + place filter paper under eyes-tears travel <10mm (should be 20mm+)
86
Treatment of Sjogren's?
Artificial tears, saliva + lubricant for sexual activity *Sometimes hydroxychloroquine given for fatigue, myalgia and rashes (up to dr)
87
What is scleroderma?
Systemic condition also known as systemic sclerosis, is a group of rare diseases that involve the hardening and tightening of the skin.
88
Most common type of scleroderma?
CREST- limited cutaneous scleroderma
89
Conditions CREST is made up of?
Calcinosis Raynauds Esophageal dysmotility/strictures Sclerodactyly Telenagiectaria
90
What is Calcinosis and what does it lead to?
Ca deposits in SC tissue -> renal failure Look like bright white deposits on x-ray
91
What is Raynaud's?
Digit ischemia due to sudden vasospasm, often precipitated by the cold and relieved with heat Classic patient has white fingers
92
what is Sclerodactyly and what dose it lead to?
Local skin thickening or tightening on fingers/toes -> movement restriction
93
What is Telangiectasia and what does it lead too?
Spider veins -> risk of pulmonary htn
94
Investigations to diagnose scleroderma (CREST)?
Anti centromere antibodies (ACAs) - 70% ANA often +ve
95
Treatment for scleroderma (CREST)?
No Cure Treat Sx (e.g raynauds = handwarmers, GI Sx = PPI etc) Annual echo’s and pulmonary function tests Prevent renal crisis using ACEi
96
What is polymyositis/dermatomyositis?
Inflammation + necrosis of skeletal muscle Where skin is involved it is called dermatomyositis
97
Risk factors for polymyositis/dermatomyositis?
Females -HLA B8/DR3 genetic link
98
Symptoms of polymyositis/dermatomyositis?
Symmetrical wasting of muscles of shoulders + pelvic girdle - Hard to stand from sitting, to squat - Hard to put hands on top of head Dermatomyositis = + skin changes - Gottron papules- scales on knuckles - Heliotrope - purple eyelid
99
Investigations to diagnose polymyositis/dermatomyositis?
Muscle enzymes (CK)Muscle fibre biopsy, necrosis = diagnostic LDH + CK raised Anti Jo1 + Anti Mi2 Ab's --> dermatomyositis only
100
Treatment for polymyositis/dermatomyositis?
Bed rest + prednisolone (1 month then taper dose down) => Steroids and then immunosuppressive drugs
101
What is fibromyalgia?
MSK equivalent of IBS = chronic widespread pain (MSK) for 3months+ with all other causes ruled out *Affects non nociceptive pain pathway
102
What is nociceptive pain compared to non-nociceptive pain?
img
103
Typical patient presentation of fibromyalgia?
-Females -Depression + stress -Poor -60+
104
Symptoms of Fibromyalgia?
-Stressed depressed female 60+ -Fatigue -Sleep disturbance + morning stiffness (esp back, neck stiff) -Pain
105
Investigations to diagnose Fibromyalgia?
-No serological markers -No increased ESR/CRP -Pain in 11+ / 18 regions palpated on body => DIAGNOSIS CLINICALLY MADE
106
Treatment of fibromyalgia?
- Educate what it is to patient - Physiotherapy - Antidepressants for severe neuropathic pain (eg. TCAs, -Amitriptyline) - CBT
107
Differential diagnosis for fibromyalgia?
Polymyalgia Rheumatica (PMR)
108
What is PMR?
Large cell vasculitis presenting as chronic pain syndrome - affects muscles and joints (similar to fibromyalgia)
109
Who does PMR effect?
Females always 50+
110
Investigations to diagnose PMR?
Increase ESR + CRP = diagnostic - Temporal artery biopsy may show GCA, and may have anaemia of normocytic/chronic disease
111
Treatment of PMR
Oral prednisolone
112
What is Vasculitis and where can it occur?
Inflammation of vessels -> large/medium/small vessels
113
What conditions occur in large vessels?
GCA (giant cell arteritis) -Takayatsu (asian women, affects aortic arch, otherwise same as GCA)
114
What conditions occur in medium vessels?
- Polyarteritis nodosa - Buerger's disease (male smokers 20-40, peripheral skin necrosis) - Kawasaki disease (children, causes coronary artery aneurysms)
115
What conditions occur in small vessels?
- Eosinophilic granulomatosis w/polyangitis (EGPA) ("Churg strauss disease" pANCA +ve) - Granulomatosis w/polyangitis (Wegener disease (cANCA +ve) causes glomerulonephritis + pulmonary symptoms and saddle shaped nose) - Henloch schonlein purpura
116
What is Henloch schonlein purpura? (HSP)
IgA vasculitis and a differential diagnosis for IgA nephropathy *both present as IgA deposition in GBM in kidney biopsy BUT HSP has a purpuric rash on shins + affects other organs (joints, abdo, renal)
117
General treatment for Vasculitis?
Corticosteroids
118
What to consider when steroids given long-ish term?
GI and bone protection - PPI - Bisphosphonate
119
Typical patient presentation of giant cell arteritis (GCA)?
50+ Caucasian female presenting with: - unilateral temple headache - jaw claudication - +/- vision changes - temporal scalp tenderness Particularly prevalent in Scandinavians
120
Symptoms of GCA?
Affects external carotid branches: - temporal branch=scalp tenderness - ophthalmic branch=vision (blurring, Diplopoda, photopsia, loss) - facial branch=jaw and tongue claudication
121
Investigations to diagnose GCA?
Increased ESR +/- CRP = 1st line Temporal artery biopsy = granulomatous inflammation of media + intima = diagnostic Or Temporal artery ultrasound Or both * often patchy skip lesions so take a big sample
122
Treatment of GCA?
Corticosteroids (prednisolone) 40- 60 mg with no delay, higher doses of 60 for those patients with a history of ischaemia symptoms including visual loss, limb or jaw claudication IV methylprednisolone for those with visual loss Aim to taper prednisolone to zero over 12-18 months provided no return in symptoms
123
Complication of GCA?
Sudden painless vision loss in one eye (optic neuropathy): - temporary = amaurosis fugax (typically seen in TIA) - may be permanent if not dealt with asap with high dose IV Methylprednisolone - overall visual outcomes are poor
124
What is polyarteritis nodosa?
Blood vessel inflammation that causes injury to multiple organ systems
125
What sex is more affected with polyarteritis nodosa?
males
126
What condition is associated with polyarteritis nodosa?
Hep B
127
Symptoms of polyarteritis nodosa?
Severe systemic symptoms: - mononeuritis multiplex (ischaemia of vasa nervosum) - GI bleeds (mesenteric artery) - CKD/AKI (renal artery)- causing pre renal AKI - skin nodules + haemorrhage
128
Investigations to diagnose polyarteritis nodosa?
CT angiogram = looks like 'beads on string' (microaneurysms) Biopsy (kidney) = necrotising vasculitis due to e.g htn
129
Treatment for polyarteritis nodosa?
1) Corticosteroids (prednisolone) 2) Control hypertension with ACE-inhbitors 3) Hep B treatment given after corticosteroids
130
What are Spondylarthropathies?
Asymmetrical seronegative (rheumatoid factor -ve) arthritis - associated w/HLAB27 - an MHC-I serotype (interacts with T cells) - Inflammatory
131
General features of Spondylarthropathies?
SPINEACHE - Sausage fingers (dactylitis) - Psoriasis - Inflammatory back pain - NSAIDS good response - Enthesitis (plantar fasciitis, inflamed heel tendon) - Arthritis - Crohn's or Colitis = IBD - HLAB27 - Eyes -> Uveitis
132
Types of Spondylarthropathies?
Ankylosing Spondylitis Psoriatic Arthritis Reactive Arthritis + IBD associated arthritis
133
What is ankylosing spondylitis?
Abnormal stiffening of joints (sacroiliac + vertebral) due to new bony formation
134
Risk factors for ankylosing spondylitis?
young males HLAB27 +ve
135
Pathophysiology of ankylosing spondylitis?
Syndesmophytes (vertical abnormal bony growth) replace spinal bone damaged by inflammation + makes spine much less mobile - also causes inflamed tendons, eye, fingers
136
Typical patient presentation of Ankylosing spondylitis?
Young male with progressively worsening back stiffness - Worse in morning/night - Better with exercise
137
Symptoms of Ankylosing Spondylitis?
- anterior uveitis - ertheritis - dactylitis - Lumbar pathology: - decreased in natural lumbar lordosis - Schober test shows decreased lumbar flexion (<20cm)
138
Investigations to diagnose ankylosing spondylitis?
X-Ray = bamboo spine + sacroiliitis + squared vertebral bodies + syndesmphytes (fusion of vertebral bodies MRI -> can show sacroiliitis before X-ray therefore better screening tool ESR and CRP will be raised and can be HLA-B27 +ve
139
Treatment for Ankylosing Spondylitis?
Symptoms can be treated with exercise and/or NSAIDS (steroid injection if severe) Biologics: DMARD (improve disease) = TNF alpha blockers: - Infliximab (mAB) - Etanercept
140
Last resort for ankylosing spondylitis?
Surgery
141
What % of people who have psoriasis develop psoriatic arthritis?
10-40% within 10 years
142
Moderate symptoms of psoriatic arthritis?
- Inflamed DIP joints - Nail dystrophy (onycholysis) - Dactylitis - Enthesitis - Psoriatic rash on skin on hidden sites -> behind ears, scalp, under nails, penile
143
Severe symptom/complication of psoriatic arthritis?
Arthritis mutilans (5%) = pencil in cup deformity: - osteolysis of bone = progressive shortening - fingers telescope in on themselves
144
Treatment of psoriatic arthritis?
Symptoms = NSAIDS DMARD = methotrexate most commonly if it occurs outside the spine = > treatment is similar to rheumatoid arthritis - if that fails = anti TNF (infliximab, etanercept) - if that fails IL 12+23 inhibitors (ustekinumab) - IL 17 blockers (secukinumab)
145
What is reactive arthritis?
sterile inflammation of synovial membranes + tendons and fascia - usually reacting to a distant infection - eg. GI or STI
146
Causes of reactive arthritis?
Gastroenteritis = C.jejuni, salmonella, shigella, Yersinia - STI = C.trachomatis, N.Gonorrhoea, Urea urealyticum
147
Most common cause of reactive arthritis?
C.trachomatis
148
Symptoms of reactive arthritis?
Can't see, can't pee, can't climb a tree -> uveitis/conjunctivitis, urethritis/balanitis, arthritis + Enthesitis *may have keratoderma blennorrhagicum (browny discoloured rash and soles of foot) - or circinate balantitis (small sores/lesions of the head of the penis)
149
Main differential diagnosis of reactive arthritis?
Septic arthritis: - painful hot swollen joint - red - signs or history of infection
150
Investigations to diagnose reactive arthritis?
joint aspirate (remove fluid from space around a joint) = MC + S shows no organism - Plane polarised light microscopy = -ve for crystalarthropathy - sexual health review - stool culture - ESR/CRP increases and may be HLAb27 +ve
151
Treatment of reactive arthritis?
Symptoms = NSAIDS (+ steroid injection) Mostly single attack -> if have 6+ months of recurrence = CHRONIC -> methotrexate
152
What is septic arthritis?
Direct bacterial infection of joint (either direct access, or haematogenous spread)
153
Why is septic arthiritis a medical emergency?
Acutely inflamed joint with fever, typically knee, is extremely painful => Can destroy knee in ≤24hrs
154
What organisms can cause septic arthiritis and which are most common?
S.aureus = most common H.influenza (historically in children- but now rare due to immunisation) N.gonorrhea E.coli/pseudomonas
155
Risk factors for septic arthritis?
IVDU - Immunosuppression - Recent surgery - Trauma - Prosthetic joints - inflammatory joint disease (RA)
156
Investigations to diagnose septic arthritis?
Urgent joint aspirate with MC+S & polarised light microscopy - normal joint aspirate is clear and yellow but infected is cloudy and turgid - Check for Increased ESR/CRP - Consider blood culture - sexual health review (due to potential gonorrheareal cause)
157
Differential diagnosis of joint pain using aspirate and culture + light microscopy?
1) Septic arthritis = ID causative organism 2) Reactive arthritis = sterile and crystal free joint 3) Gout = sterile and -ve birefringent needle crystals 4) Pseudogout = sterile and +ve birefringent rhomboid crystals
158
Treatment of Septic arthritis?
Joint aspiration (drainage) ALWAYS then empirial Antibiotics: - flucoxacillin + rifampicin (gram -ve eg e.coli) - vancomycin (MRSA) - IM ceftriaxone + azithromycin (gonorrhoea) - joint washout until no recurrent effusion * if on methotrexate/anti-TNFa then STOP THESE + Use NSAIDs for pain relief - rest/ splint/ physio - stop any immunosuppression temporarily if you can
159
Treatment for septic arthritis if on steroids?
Double prednisolone dose (increased stress response)
160
What are prosthetic joints commonly infected with?
Cuagulase -ve Staphs eg. S. epidermis
161
What is osteomyelitis?
Acutely inflamed, infected bone marrow via haematogenous or local spread (eg from infected joint/trauma)
162
What age group does oesteomyelitis commonly occur in?
Mainly in children (85%) - long bones > vertebrae In adults they’re usually >50yrs - vertebrae > clavicle/pelvis>>long bones
163
What is the most common type of spread of osteomyelitis in children + adults?
Children = haematogenmous Adults = local
164
What organsisms can cause osteomyelitis?
- S.aureus (90%) - Salmonella in sickle cell patients
165
Risk factors of Osteomyelitis?
IVDU - Immunosuppression - PVD - DM - Sickle cell anaemia - inflammatory arthritis - UTI, urethral catheterisation - central lines, on dialysis - Trauma
166
Cause and spread of osteomyelitis?
Direct innoculation organism - due to Trauma or surgery and Can be any bacteria - Contiguous spread- from adjacent soft tissues and joints (repaired joints or Prosthetic) RF- Diabetes - Haematogenous - children (long bones) > adults (vertebrae) (monomicrobial)
167
Acute bone changes in osteomyelitis?
inflammation and bone oedema
168
Chronic bone changes and complications of osteomyelitis?
1) Sequestra (necrotic bone embedded in pus) 2) Involucrum (thick sclerotic bone placed around sequestra to compensate for support = abnormal)
169
Acute Symptoms of osteomyelitis?
Dull bony pain + hot swollen area (+/- joint) - Worse with movement
170
Chronic symptoms of osteomyelitis?
Also have deep ulcers (sequestrae)
171
Differential diagnosis for Osteomyelitis?
Charcot joint = (damage to sensory nerve due to diabetic neuropathy) - causes progrssive degeneration of weight bearing joint + bony destruction - Often presents with "diabetic feet" Soft tissue infection Avascular necrosis of bone Gout
172
Investigations to diagnose osteomylitis?
Bone marrow biopsy + culture + blood mc+s -> IDs causative organism X-Ray for osteopenia MRI (after XR) = bone marrow oedema Check for increased ESR/CRP
173
Treatment for Osteomylitis?
Immobilise + Abx: - vancomycin or teicoplanin (MRSA + s.aureus) - fusidic acid (s.aureus) - flucoxacillin (salmonella) Start with a broad antibiotic and then focus according to culture findings Surgical= debridement or hardware placement or removal
174
Vancomycin vs teicoplanin?
Teicoplanin is longer lasting than vancomycin but increased side effects: - GI upset - pruritus - rash
175
What is important when considering osteomyelitis patients?
Rule out tuberculosis osteomyelitis with bone marrow biopsy (caseating granuloma +ve on histology) - may be slower onset - longer treatment of 6 months
176
4 primary bone tumours?
Osteosarcoma - Ewing sarcoma - Fibrosarcoma - Chondrosarcoma
177
Prevalence of bone tumours?
1° are rarer and seen mostly in children 2° are most common
178
Most common types of cancer that can resut in secondary bone metastases?
BLT KP - Breast - Lung - Thyroid - Kidney - Renal cell cancer - Prostate *myeloma can also cause bone pain
179
Of secondary bone cancers, which are osteolytic and osteosclerotic?
Osteolytic (softened bone, due to loss of calcium) = breast + lung Osteosclerotic (Abnormal bone hardening) = prostate
180
What is the most common primary bone tumour?
Osteosarcoma
181
Which organ does osteosarcoma metastisise to?
Lungs
182
What is osteosarcoma associated with?
Pagets and 15-19 yr old patients
183
Investigation to diagnose osteosarcoma and results?
X-ray= "sunburst" appearing bone
184
What cells does ewing sarcoma originate from?
Mesenchymal (multipotent stem cells found in bone marrow) stem cells
185
Prevalence of Ewing sarcoma?
Very rare and mostly in teens (15yr olds)
186
What is Chondrosarcoma?
Cartilage cancer
187
General local symptoms of bone tumours?
Severe pain = worst at night (wake up in middle of night) Decreased ROM of long bone and/or verterbrae Lump - pressure effect on local structures, snapping of tendons etc
188
General systemic symptoms of bone tumours?
Weight LOSS - Fatigue - Fever - Malaise
189
Investigations to diagnose bone tumours?
Skeletal isotope scan (shows changes before XR) - XR = shows osteolysis or osteosclerosis - Increased ALP, ESR/CRP - Hypercalcemia (of malignancy) - Biopsy - percutaneous, excisional, incisional = definitive diagnostic test
190
General treatment of bone tumours?
Chemo or radiotherapy - Bisphosphates - surgery eg. Tumour excision or angioembolization
191
What is osteomalacia and it’s cause?
Defective bone mineralisation - due to vitamin D deficiency => decreased Ca2+ + PO43- (hydroxyapatite mineral of bone)
192
Osteomalacia vs Rickets?
Osteomalacia = After epiphyseal fusion Rickets = Before epiphyseal fusion
193
What are the 5 causes of osteomalacia?
1) HyperPTH 2) Vit D deficiency 3) CKD/Renal failure 4) Liver Failure 5) Anticonvulsant drugs
194
Draw out the Vitamin D pathway
img
195
How does hyperPTH cause osteomalacia?
CA2+ released from bone so less available for mineral formation - Seconadary reason is due to vit D deficiency
196
How does Vitamin D deficiency cause osteomalacia?
most common cause - due to malabsorption/reduced intake/Poor sunlight - Results in decreased absorption of calcium from gut and decreased reabsorption in renal pct
197
How does CKD/renal disease cause osteomalacia?
Reduced activation of vitamin D (1-alpha-hydroxylation)
198
How does liver dysfunction cause osteomalacia?
Reduced activation of vitamin D (25-hydroxylation)
199
How can anticonvulsive drugs cause osteomalacia?
Increase CYP450 metabolism of vitamin D
200
Symptoms of osteomalacia?
Fractures - proximal weakness - Difficulty Weight bearing
201
Symotoms of Rickets?
Skeletal deformities: - knocked knees - bow legs - wide epiphyses
202
Investigations to diagnose osteomalacia?
- BM biopsy = incomplete mineralisation - Bloods: hypocalcemia Increased PTH Decreased serum Ca2+ Decreased 25-hydroxyvit D (best marker) X ray = Looser's zones (defective mineralisation)
203
Treatment for Osteomalacia?
- Vit D replacement (calcitriol) - Increase dietary intake (D3 tablets + eggs)
204
What is Paget's disease?
Focal disorder of bone remodelling (areas of patchy bone due to improper osteoblast/clast function) Typicall idiopathic and presents in females 40+
205
Symptoms of Paget's?
- Bone pain - Bone changes: - bowed tibia - skull changes - Neurological Sx: - nerve compression of CN8 (deafness) - hydrocephalus (sylvian aquaduct blockage)
206
Investigations to diagnose Paget's?
X-Ray: - osteoporosis circumscripta - cotton wool skull (skull changes; lysis + sclerosis) Urinary hydroxyproline: protein constituent of bone collagen = good marker of progression Also may have increased ALP
207
Treatment for Paget's?
Give bisphosphonates + NSAIDS for pain relief
208
What is marfans syndrome?
Connective tissue disorder = inherited - due to auto dominant FB1 mutation => decreased connective tissue tensile strength
209
What are the symptoms of marfans syndrome?
1) "Marfans body habitus": - tall + thin - long fingers (arachnodactyly) - pectus excavatum/carinatum (sternum pressed in/puffed out) 2) Aortic complications: - aortic regurgitation murmur - AAA - aortic dissection
210
Investigations to diagnose marfans?
Clinical diagnosis + FBN-1 mutation positive test
211
What is Ehlers-Danos?
Connective tissue disorder: - auto dominant mutations affecting collagen proteins with 13ish subtypes
212
Symptoms of Ehler's danos?
joint hypermobility - CV complications: mitral regurg + AAA
213
Investigations to diagnose Ehlers danos?
Clinical Diagnosis - look for collagen mutations (beighton score?) - Echo
214
What will connective tissue disorders result in?
1) Weak valves 2) Weak vessels Key complications to monitor: - regurgitation murmurs - aortic aneurysm ruptures/aortic dissection
215
What is mechanical lower back pain?
- Common patient complain in community - Very common and often self-limiting - May be normal, especially people 20-55yrs old - Can be trauma or work related
216
Signs for serious pathology in mechanical lower back pain?
Elderly (e.g myeloma) - neuropathic pain (spinal cord compression)
217
What is lumbar spondyloisis?
Degeneration of IV disc acuses it to lose its compliance + thin over time More common in older patients
218
Symptoms for lumbar spondylosis?
Initally asymptomatic -> progressively worsens
219
What spinal levels are most commonly affected by lumbar spondylosis?
L4/5 or L5/S1
220
Investigations to diagnose Lumbar spondylosis?
X-Ray + MRI if a serious pathology is suspected eg. neurological pain
221
Treatment of lumbar spondylosis?
Main treatment is analgesia and physiotherapy if this is simple mechanical pain
222
Can you see bone inflammation on x-ray?
No but it is obvious on MRI
223
Main bacterial cause of osteomyelitis?
STAPH AUREUS
224
When do you stop osteomyelitis treatment?
It’s very variable but 6 weeks of IV Abx is considered minimum - switch to oral may work in some circumstances - stop treatment guided by CRP response - failure to respond requires re-imaging
225
Why is treatment so long for osteomyelitis?
Vascular supply and microbial virulence factors make antimicrobial treatment complex and long
226
What is gonococcal arthritis?
Occurs with disseminated gonococcal infection. - causes Fever, arthritis, tenosynovitis - maculopapular- pastular rash - painful before visible
227
What is debridement?
Removal of all infected tissue and bone and thorough cleaning of wounds
228
What would you suspect in a young patients presenting with single acutely swollen joint?
Gonococcus septic arthritis until proven otherwise - this infection is common and delaying treatment puts joint in danger - if the patient has urinary or genital symptoms, exclude gonococcal septic arthritis first before considering reactive arthritis
229
Joints affected typically by gout?
Feet Ankles Knees Elbows Hands
230
Joints typically affected by pseudo gout?
Wrist Knees Hands
231
Age of onset in Inflammatory arthritis vs osteoarthritis?
Inflammatory: can happen at any age Osteoarthritis: usually later in life
232
Speed of onset Inflammatory arthritis vs osteoarthritis?
Inflammatory arthritis: rapid, weeks to months Osteoarthritis: slow, over years
233
Distributed of Inflammatory arthritis vs osteoarthritis?
Inflammatory arthritis: symmetrical polyarthritis Osteoarthritis: initially asymmetrical mono arthritis —> polyarthritis
234
Joints affected with Inflammatory arthritis vs osteoarthritis?
Inflammatory arthritis: small joints of hands and feet Osteoarthritis: weight bearing joints- knees, hips, thumb base, big toe
235
Duration of morning stiffness Inflammatory arthritis vs osteoarthritis?
Inflammatory arthritis: Stiffness worse in the morning >1 hr Osteoarthritis: Stiffness <1hr and worse at the end of the day
236
Areas of the body affected with psoriatic arthritis?
Spine - asymmetrical big joints - isolates fingers and toes
237
Why might uric acid levels be low in gout?
Going through an attack so uric acid goes to the joint
238
Aim of gout treatment?
To reduce uric acid below <300umol/1 Start at 100mg allopurinol and increase every 2-4 weeks until target met
239
Complications of gout?
- disability and misery - Tophi - Renal disease: - calculus 10-15% - chronic update nephropathy -acute rate nephropathy (cytoxics)
240
Why is a normal x ray not conclusive when dismissing rheumatoid arthritis?
Takes up to 6 months of disease to show up on x ray
241
Why do we want to catch rheumatoid arthritis earlier?
Lots of evidence that early diagnosis and treatment makes a huge difference to prognosis Inflammation is reversible but damage is not “Window of opportunity” where DMARDs can settle disease very quickly
242
Anti- CCP vs Rheumatoid factor in diagnosing RA?
- rheumatoid factor is falsely positive in 10-15% of patients - anti- ccp is almost never falsely positive
243
Types of connective tissue diseases?
Inherited Auto immune (inflammatory)
244
How many people inherit Marfans?
3/4 and the rest develop it with no family history
245
Joint deformations in SLE?
Can look very similar to rheumatoid arthritis but non erosive and less proliferative
246
How to diagnose lupus nephritis?
Crescent formation in histology
247
Haematological features of SLE?
Anaemia (haemolytic, Coombs positive) Thrombocytopenia Neutropenia Lymphopenia
248
Auto antibodies with SLE?
Double stranded DNA antibody is specific to lupus
249
What is anterior Uveitis?
Also called iritis and it is inflammation of the iris and/or the ciliary body and is a frequent extra-articulate manifestation of axial spondyloarthritis
250
Why is HLA b27 allele special?
It’s presence alone can cause spondyloarthritis
251
How might HLAb27 cause spondyloarthritis?
- “molecular mimicry” infection —> immune response—> infectious agent has peptides very similar to HLAB27 molecule - > autoimmune response triggered against HLA B27 - misfolding theory - HLA b27 heavy chain homodimer hypothesis
252
Symptoms for inflammatory back pain in ankylosing spondyloarthritis?
Inflammatory back pain which: - starts under 40yrs of age - wake up at night with back pain that improves with movement - improvement with exercise - insidious onset
253
Types of bone tumour
Primary Secondary/metastatic
254
Types of primary bone tumour
Based on biological behaviour: - Benign - slow and don’t spread - Intermediate - Malignant - grow fast and spread to distant sites
255
Differential diagnosis for bone tumours?
Infection - Hyperparathyroidism (Brown’s Tumour)
256
Staging of Bone tumours?
Enneking staging - AJCC TNM staging system
257
What is benign osteochondroma?
Exostois that is most common around the knee = aberrant growth of fragment of epiphyseal plate Treatment is excision
258
Most common sites for bone metastases in order
1. Lung 2. Liver 3. Bone
259
Aims of fracture treatment?
Relieve pain + disability, to improve function
260
Fracture treatment?
4Rs: (Deal with catastrophic bleeding) - Resuscitate - Reduce the fracture to correct alignment - Retain the position of the fracture (using splint, pins, rods etc) - Rehab
261
How to present an Orthopedic x-ray?
ALWAYS USE TWO ORIENTATIONS/VIEWS (fracture might not be visible at both) Intro : who, what, when ABCs Alignment - dislocation Bones- fractures= pattern/position of fracture, condition and displacement Cartilage - widened joint Soft tissues - swelling, effusion
262
Patterns of fractures
Transverse - common in younger fitter patients Oblique Spiral
263
Conditions of fracture?
Comminuted - greater soft tissue involvement Segmental -usually only one fracture will heal out of the two Impacted - inherent stability so might not have to do anything
264
How to describe displacement of bones?
- length eg shortened - alignment eg translation or angulation - rotation ?
265
Types of soft tissue swelling?
Intra articular Extra articular
266
Types of bone healing?
Direct: absolute stability and compression with gap healing => no callus *can only be done with a gap of <1mm* Indirect: relative stability => movement causes callus formation *if gap is larger than 1mm*
267
Bone remodelling cycle?
img
268
Callus formation in bone?
img
269
Stages of osteoarthritis
1-4 1 is doubtful with minimum disruption but 10% cartilage loss 4 is severe with joint space largely reduced and 60% cartilage loss
270
Radiological features of osteoarthritis
joint space narrowing - osteophyte formation - Subchondral sclerosis - suchondral cysts - abnormalities of bone contour
271
Controversial subset of osteoarthritis?
Inflammatory/erosive arthritis with a strong inflammatory component - some radiologist don’t believe it exist - in addition to standard to standard management , DMARD therapy (usually milder agents) often used
272
Lifestyle treatments for chronic gout?
Dietary modifications: - alcohol (reduce, beer to cider) - Lose weight - Reduced red meat, offal, shellfish, fructose containing drinks
273
Pathophysiology of vasculitis?
activated immune cells infiltrate vessel walls and lead to Direct damage and stimulate vascular smooth muscle cell remodelling - vessel wall infiltration, proliferation and damage causes weakening and occlusion of blood vessel - leads to ischaemia, infarction, aneurysm - Results in clinical manifestations
274
How to classify vasculitis?
1. By vessel size 2. Consensus classification (Chapel-Hill 2012) - hybrid classification of vessel size, pathophysiology and underlying cause
275
Important negative features of GCA?
Features of a serious headache but not of GCA - Vomiting ( raised intercranial pressure) - Any acute localising clinical signs ( acute intracerebral bleeding, encephalitis, meningitis) - Fever (infection)
276
New persistent headache in an elderly patient?
Must be treated seriously and is GCA until proven otherwise - Dont delay treatment with steroids and refer to rheumatology
277
What proportion of women and men over age 50 will have a fracture due to osteoporosis?
50% of women 1 in 5 men
278
Three classic fractures of osteoporosis?
Hip fracture Wrist fracture Vertebrae fractures
279
Morbidity of hip fractures?
20% of patients will die in the next year
280
Factors that play a role in fracture?
Combination of trauma and bone strength
281
Factors that effect bone strength?
Peak bone mass/rate of bone loss Bone size Bone turnover Bone architecture Bone mineralisation
282
Post menopausal osteoporosis?
Loss of restraint effects of oestrogen on the burn turnover Characterised by: - high bone turnover (resorption>formation) - predominantly cancellous bone loss - microarchitectural disruption
283
Changes in trabecular architecture with ageing?
decrease in trabecular thickness, more pronounced for non-load bearding horizontal trabeculae - decrease in connections between horizontal trabeculae - decrease in trabecular strength and Increased susceptibility to fracture
284
What is bone densitometry for?
For risk assessment and for diagnosis, the characteristic of major importance is the ability of a technique to predict fractures
285
Two types of treatments for osteoporosis?
1) Anti-resorptive - decrease osteoclast activity and bone turnover - Bisphosphonate = 1st line - HRT - Denosumab 2) Anabolic - Increase osteoblast activity and bone formation - Teriparatide
286
Denosumab?
Rapid acting and very potent anti-resorptive Good fracture risk reduction BUT rebound increase of bone turnover when stopped
