MSK/Rheumatology Flashcards
1
Q
describe the disease process behind osteoarthritis
A
general wear and tear, a chronic degenerative disease.
loss of articular cartilage - exposed bone becomes sclerotic.
attempts at repair produces osteophytes (nodules).
2
Q
describe the usual onset of osteoarthritis
A
> 50yrs, slow and gradual
3
Q
describe the pattern of joint involvement of osteoarthritis
A
asymmetrical.
finger joints, thumbs + weight bearing joints (hip/knee)
4
Q
what hand changes are common to osteoarthritis?
A
Heberden’s (DIP) + Bouchard’s (PIP) nodes.
NO swelling.
5
Q
what systemic features are present in osteoarthritis?
A
NONE
6
Q
describe the character of the pain from osteoarthritis
A
increases with movement, worse at the end of the day.
7
Q
what would the lab findings be in osteoarthrits?
A
RhF -ve, ANA -ve, raised CRP, normal ESR
8
Q
what would be the radiological findings in osteoarthritis?
A
LOSS.
Loss of joint space, Osteophytes, Subchondral cysts, Sclerosis.
9
Q
what main features would you use to differentiate between rheumatoid and osteoarthritis?
A
pattern of joint involvement.
absence of systemic features of OA.
RA has marked early morning stiffness lasting >60mins.
10
Q
how would you treat osteoarthritis?
A
exercise for local muscle strength/aerobic fitness.
analgesia - paracetamol ± topical NSAIDs.
codeine/short-term oral NSAID (+PPI).
intra-articular steroid injections.
joint replacement surgery.
11
Q
describe the disease process behind rheumatoid arthritis
A
chronic systemic inflammatory, autoimmune disease.
production of cytokines (IL-1,2,4,6,8 + TNFalpha) by T cells = inflammation.
local rheumatoid factor production.
synovitis => pannus formation => pannus destroys articular cartilage and subchondral bone.
12
Q
describe the usual onset of rheumatoid arthritis
A
aged 30-50. rapid, within a year.
13
Q
describe the pattern of joints affected by rheumatoid arthritis
A
symmetrical.
small and large joints on both sides.
>3 affected, hands usually involved.
14
Q
what hand changes are common to rheumatoid arthritis?
A
swan neck deformity, Boutonniere’s deformity, Z thumb, ulnar deviation, hot swollen joints.
15
Q
what systemic features are present in rheumatoid arthritis?
A
elbow and lung nodules, vasculitis, pericarditis, carpal tunnel, Sjorgen’s, Raynaud’s, lymphadenopathy, fever, fatigue
16
Q
describe the character of the pain from rheumatoid arthritis
A
morning stiffness >60 mins.
pain is accompanied by stiffness.
17
Q
what would the lab findings be in rheumatoid arthritis?
A
RhF +ve, anti-CCP +ve (highly specific for RA), raised CRP, raised ESR
18
Q
what would be the radiological findings in rheumatoid arthritis?
A
LESS.
Loss of joint space, Erosions, Soft bone, Swelling of soft tissue.
19
Q
how would you treat rheumatoid arthritis?
A
DMARDs - sulfasalazine, methotrexate.
Biological agents - infliximab, rituximab, tocilizumab etc.
NSAIDs - diclofenac, ibuprofen.
Steroids for flare ups (IM methylprednisolone).
20
Q
what is the diagnostic criteria for rheumatoid arthritis?
A
need 4 out of 7:
morning stiffness >1h.
3+ joints affected.
arthritis in hand joints.
symmetrical.
rheumatoid nodules.
RhF+ve.
radiological changes.
21
Q
what rheumatoid arthritis treatment requires regular pregnancy tests in women of child-bearing age and why?
A
methotrexate - it’s a folic acid antagonist, risk of neural tube defects is high.
22
Q
what disease lowers your risk of developing osteoarthritis?
A
osteoporosis
23
Q
define osteoporosis, in general terms
A
low bone mass and micro-architectural deterioration leading to bone fragility and increased fracture risk
24
Q
give 5 risk factors for osteoporosis
A
age, parental history, alcohol (>4units/day), RA, BMI less than 19, steroids (5mg/d prednisolone).
Hyperthyroidism, hyperparathyroidism, hypercalciuria.
Alcohol and tobacco use.
Thin (BMI less than 19)
25
what fractures might alert you that a patient could have osteoporosis?
thoracic and lumbar vertebrae.
proximal femur.
distal radius (Colles' fracture).
26
what is the gold standard investigation for osteoporosis?
DEXA bone scan.
27
what lifestyle measures should an osteoporosis patient take?
smoking cessation, low alcohol intake, weight bearing exercises, calcium and vit D rich diet, home help.
28
how would you medically treat osteoporosis?
bisphophonates e.g. alendronate, zolendronate
calcium + vit D.
strontium ranelate - if intolerant to bisphosphonates.
HRT is preventative, but not used to treat.
29
explain the pathophysiology of SLE
apoptotic cells and cell fragments aren't cleared efficiently by phagocytes - taken to lymph nodes, taken up by APCs.
APCs present self-antigens from these fragments to T cells, activating B cell proliferation and production of autoantibodies.
Leads to antibody formation, immune complex deposition, complement activation and influx of neutrophils = clinical manifestations.
30
what 3 genes is SLE associated with?
HLA-B8, DR2, DR3
31
what are the WHO diagnostic criteria for SLE?
need 4 out of 11 - SOAP BRAIN MD
Serositis
Oral ulcers
ANA +ve
Photosensitivity
Blood disorders
Renal disorder
Arthritis
Immunological disorder
Neurological disorder
Malar rash
Discoid rash
32
what autoantibodies might you find in a patient with SLE?
ANA, anti-Ro, anti-dsDNA, anti-La
33
what histological features might you see on investigation of a patient with SLE?
deposition of IgG and complement in kidneys and skin
34
give 6 symptoms of SLE
Raynaud's, chest pain, dyspnoea, depression, fatigue, dry eyes/mouth, abdominal pain, joint pain, muscle pain, polyneuropathy/sensory loss
35
give 6 signs of SLE
malar rash, discoid rash, photosensitivity rash, purpura, weight loss, lymphadenopathy, oral/nasal ulcers, bruising, proteinuria, fever, pallor due to anaemia
36
how might you monitor SLE activity?
anti-dsDNA antibody titres.
complement - low C3/C4.
ESR.
37
what ESR/CRP results would make you think of SLE?
multisystem disorder with raised ESR but normal CRP
38
how would you manage a severe flare of SLE?
IV cyclophosphamide and high-dose prednisolone.
39
how would you manage the cutaneous symptoms of SLE?
topical steroids, strong sunblock/avoid sun exposure
40
describe maintenance treatment for SLE
NSAIDs, hydroxychloroquine, low-dose steroids, azathioprine/methotrexate or mycophenolate
41
how would lupus nephritis be managed?
needs more intense immunosuppression than SLE:
cyclophosphamide/mycophenolate
42
what are the 4 characteristic clinical features of anti-phospholipid syndrome?
coagulation defect, livedo reticularis (blue/pink mottling), obstetric problems (miscarriages), thrombocytopenia (bleeding)
43
what is antiphospholipid syndrome?
associated with SLE, or a primary disease.
there are antiphospholipid antibodies causing CLOTS - leads to the features of miscarriages, livedo reticularis etc
44
what are the 3 diagnostic investigations to be carried out in antiphospholipid syndrome?
lupus anticoagulation test, anti-beta2 glycoprotein test, anticardiolipin test.
indicate +ve blood test for antiphospholipid antibodies.
45
how would you manage a patient with antiphospholipid syndrome?
warfarin, if there's recurrent thrombosis.
if high IgG but asymptomatic, then give aspirin/clopidogrel as prophylaxis.
46
what 2 genes are associated with Sjogren's syndrome?
HLA-B8/DR3
47
give 2 secondary causes of Sjogren's
SLE, RA, scleroderma
48
what is the characteristic feature of Sjogren's and where is it seen?
dryness - eyes, mouth (vagina) - and parotid enlargement.
49
what tests would you do to diagnose Sjogren's?
Schirmer's test - filter paper on inside of eyelid for 5 mins, if less than 5mm moistened - positive for Sjogrens
50
how would you treat Sjogrens?
artificial tears and saliva replacement.
NSAIDs and hydroxycholoroquine for arthralgia.
51
explain the pathophysiology behind systemic sclerosis
autoimmune dysfunction causes overproduction of collagen.
T cells accumulate in skin and secrete cytokines which stimulate collagen deposition and stimulate fibroblasts.
scleroderma (skin fibrosis) + vascular disease.
52
what are the features of CREST syndrome?
Calcinosis of subcutaneous tissue.
Raynaud's.
oEsophageal and gut dysmotility.
Sclerodactyly - swollen, tight digits.
Telangiectasia (spider veins).
53
what parts of the body is skin involvement limited to in CREST syndrome?
hands, feet and face
54
what parts of the body are affected by diffuse systemic sclerosis?
diffuse skin involvement.
heart, lungs, GI tract and kidneys all involved.
55
what antibodies might you find on investigation of a patient with systemic sclerosis?
ANA, RhF, ACA, anti-topoisomerase, anti-RNA polymerase
56
how would you treat systemic sclerosis?
IV cyclophosphamide.
ACEi/ARBs reduce risk of renal problems.
57
what is myositis?
inflammation of striated muscle
58
what are the features of polymyositis?
progressive symmetrical proximal muscle weakness with myalgia ± arthralgia.
muscle weakness causes dysphagia, dysphonia (e.g. hoarseness), respiratory weakness.
59
give 3 features of dermatomyositis
macular rash, lilac-purple rash on eyelids with oedema, nailfold erythema, roughened red papules over knuckles/elbows/knees, subcutaneous calcification
60
give 3 extra-muscular signs of polymyositis/dermatomyositis
fever, arthralgia, Raynaud's, interstitial lung fibrosis, myocardial involvement
61
what investigation is needed to confirm a diagnosis of polymyositis/dermatomyositis?
muscle biopsy
62
what would blood tests show in a patient with polymyositis/dermatomyositis?
muscle enzymes (ALT, AST, LDH, CK, aldolase) are raised in plasma.
autoantibodies - anti-Mi2, antiJo1.
63
how would you manage polymyositis/dermatomyositis?
oral prednisolone.
resistant disease - azathioprine/methotrexate.
screen for malignancy
64
give 4 causes of Raynaud's phenomenon
SLE, systemic sclerosis, RA, polycythaemia rubra vera, hypothyroidism, Buerger's disease.
primary = Raynaud's disease
65
explain the pathophysiology of Raynaud's
peripheral digital ischaemia due to vasospasm precipitated by cold and relieved by heat
66
what are the clinical features of Raynaud's?
skin pallor, then cyanosis, then hot and red.
numbness then burning sensation and severe pain due to hyperaemia.
67
how would you manage a patient with Raynaud's?
keep hands and feet warm - gloves, heating pads.
smoking cessation.
nifedipine - CCB, vasodilates.
68
what class of drugs should be stopped in patients with Raynaud's?
beta blockers
69
what gene is associated with ankylosing spondylitis?
HLA-B27
70
what is ankylosing spondylitis?
chronic inflammatory disease of spine and sacroiliac joints, with unknown aetiology
71
does ankylosing spondylitis more commonly affect men or women?
men
72
describe the clinical features of ankylosing spondylitis
back pain.
progressive loss of spinal movement.
severe disease - kyphosis and neck hyperextension - question mark posture.
also - enthesitis, costochondritis, fatigue, acute iritis.
73
describe the back pain experienced in ankylosing spondylitis
radiating from sacroiliac joints to hips/buttocks.
worse at night, improves towards end of day.
74
name 2 diseases associated with ankylosing spondylitis
osteoporosis
aortic valve incompetence
pulmonary fibrosis
75
what antibody is NEVER seen with ankylosing spondylitis?
rheumatoid factor
76
how would you treat ankylosing spondylitis?
no cure.
NSAIDs, exercises.
TNF alpha blocker (etanercept) if NSAIDs fail.
77
give 4 clinical features of psoriatic arthritis
symmetrical polyarthritis, affects DIP joints, nail dystrophy, dactylitis, asymmetrical oligoarthritis, spinal arthritis, acneiform rashes, palmo-plantar pustulosis
78
how would you treat psoriatic arthritis?
NSAIDs - but can worsen skin lesions.
sulfasalazine or methotrexate.
79
what is reactive arthritis?
a sterile arthritis that tends to follow dysentery or UTIs
80
give some possible causative organisms of reactive arthritis
campylobacter, salmonella, shigella.
chlamydia, ureaplasma
81
what are the 3 cardinal symptoms of reactive arthritis? aka Reiter's syndrome
urethritis, arthritis and conjunctivitis
82
list some clinical features of reactive arthritis
asymmetrical joint involvement, generally of lower limbs.
skin lesions may resemble psoriasis.
iritis.
keratoderma blenorrhagica (bown plaques on soles and palms).
mouth ulcers.
enthesitis.
83
how would you treat reactive arthritis?
methotrexate and sulfasalazine
84
what is vasculitis?
inflammatory disorder of blood vessel walls, causing destruction (aneurysm/rupture) or stenosis.
affect different vessels/organs - all feature overwhelming fatigue and raised ESR/CRP.
85
what is the underlying pathology of polyarteritis nodosa?
a vasculitis - fibrinoid necrosis of vessel walls with microaneurysm formation, thrombosis and infarction in medium sized arteries.
86
list some features of polyarteritis nodosa
general - fever, malaise, weight loss, myalgia.
skin - purpura, livedo reticularis, ulcers, gangrene.
cardiac - angina, HF, pericarditis.
renal - hypertension, haematuria, renal failure.
GI - pain or perforation, malabsorption.
GU - orchitis.
87
what investigation would you carry out in polyarteritis nodosa?
angiography for liver, kidney and intestine microaneurysm.
bloods - high WCC, anaemia, raised ESR and CRP.
88
how would you treat polyarteritis nodosa?
prednisolone + cyclophosphamide.
89
what hepatic disease is associated with PAN?
hepatitis B.
90
describe the clinical features of polymyalgia rheumatica
age >50yrs.
subacute (less than 2wks) of bilateral aching, tenderness and morning stiffness in shoulder and proximal limb muscles.
± mild polyarthritis, tenosynovitis and carpal tunnel syndrome.
± weight loss, fatigue, fever, anorexia
NO weakness.
91
what is a common presenting problem in patients with polymyalgia rheumatica?
giant cell temporal arteritis
92
how would you treat polymyalgia rheumatica?
prednisolone.
PPI and alendronate for gut and bone protection.
93
how would you differentiate polymyalgia rheumatica from a myositis/myopathy?
creatinine kinase levels are NORMAL in PMR - would be raised in myositis/myopathy.
94
give 3 precipitating factors of an acute gout attack
excess alcohol, shellfish, sudden cessation/starting of gout therapy, trauma, surgery, infection, dehydration
95
give 3 risk factors for gout
high alcohol intake, obesity, >50yo, red meat intake, FHx, thiazide diuretics
96
what is gout?
deposition of monosodium urate crystals in and near joints.
97
describe how a patient might present with an acute attack of gout
hot, swollen, very very painful joint, usually the big toe
98
what investigation might you carry out in gout, and what might you see?
polarised light microscopy of synovial fluid - negatively birefringent needle crystals
99
how would you manage an acute gout attack?
high-dose NSAID or coxib (diclofenac, etoricoxib) and colchicine
100
how would you prevent recurrent gout attacks?
start allopurinol, but wait until 3 wks after the attack (can precipitate an attack intially!) - xanthine oxidase inhibitor.
lose weight, avoid long fasts, cut down alcohol excess and red meat consumption
101
give some chronic features of gout
tophi (smooth white deposits on skin) on the ears, fingers or achilles tendon.
chronic joint pain, tophi may ulcerate.
102
what crystal is deposited in pseudo-gout? how does this appear on polarised light microscopy of synovial fluid?
calcium pyrophosphate
positively birefringent rhomboid crystals
103
how does pseudo-gout present differently from gout?
usually occurs in larger joints (e.g. knee) - but pain is similar
104
what disease must you assume a patient presenting with acute pseudo-gout has until proven otherwise?
septic arthritis
105
how would you treat pseudo-gout?
NSAIDs or colchicines, aspiration of joint.
corticosteroid injection, if no infection.
106
list 3 of the 'yellow flag' psychosocial risk factors for developing persisting chronic pain
belief that pain and activity are harmful.
sickness behaviours e.g. extended rest.
social withdrawal.
emotional problems e.g. low mood, anxiety or stress.
problems at work.
problems claiming compensation/time off from work.
overprotective family or lack of support.
inappropriate expectations of treatment.
107
list 3 risk factors for chronic pain.
'yellow flag' psychosocial factors.
also:
female sex, middle age, low household income, divorced, low educational status.
108
list 2 other problems that fibromyalgia is associated with
chronic fatigue syndrome, irritable bowel syndrome, chronic headaches syndrome.
109
how long must symptoms have lasted for to diagnose a patient with fibromyalgia?
over 3 months
110
give 3 clinical features of fibromyalgia
presence of pain on palpation of 11/18 tender points, morning stiffness, poor concentration, low mood and sleep disturbance
111
what would you expect to see on investigation of a patient with fibromyalgia?
nothing - all would be normal.
diagnosis of exclusion.
112
how would you manage fibromyalgia?
CBT, education, structured exercise programmes.
amitriptyline - tricyclic antidepressant.
tramadol may help pain.
NOT steroids or NSAIDs.
113
describe the disease course of mechanical lower back pain
starts suddenly, often precipitated by injury (e.g. lifting heavy boxes at work), usually self-limiting, may be recurrent.
114
give 3 signs you may see on examination of a patient with mechanical lower back pain
scoliosis, stiff back, visible and palpable muscular spasm causing local pain and tenderness.
115
list 5 red flag features of mechanical lower back pain that would prompt you to investigate it
aged 20-55.
if pain is constant, progressive.
worse when supine.
morning stiffness.
bilateral/alternating leg pain (cauda equina!)
unrelieved by rest, night pain, thoracic pain.
PMHx of TB, HIV, immunosuppression, infection, malignancy.
fever, night sweats, weight loss, abdominal mass, neurological disturbance, leg claudication/weakness/numbness, major trauma.
116
how would you manage a patient with mechanical lower back pain if there was no sinister cause?
adequate analgesia - paracetamol, codeine.
avoid bed rest - encourage exercise and physiotherapy.
117
what is myeloma?
abnormal proliferation of a single clone of plasma cells, leading to production of monoclonal immunoglobulins (IgG or IgA).
118
what would be found in the urine of someone with myeloma?
Bence Jones proteins - paraproteinaemia leads to excretion of kappa/lambda light chains in urine
119
describe the clinical features caused by osteolytic bone lesions in myeloma
backache, pathological fractures (e.g. long bone, ribs), vertebral collapse.
hypercalcaemia.
120
what other clinical features, apart from those associated with osteolytic bone lesions, may be present in a myeloma patient?
anaemia, neutropenia or thrombocytopenia (due to marrow infiltration) - anaemia symptoms, infections and bleeding.
renal impairment due to light chain deposition in tubules.
121
what are the diagnostic criteria for myeloma?
2 out of 3:
paraproteinaemia on serum protein immunofixation or Bence Jones proteins in urine.
radiological (MRI/CT) evidence of lytic bone lesions.
increase in bone marrow plasma cells - bone marrow aspiration/biopsy
122
what would blood tests show in a myeloma patient?
normocytic, normochromic anaemia, thrombocytopaenia, leucopenia.
ESR high.
hypercalcaemia.
123
how would myeloma be treated?
chemo - melphalan + prednisolone, or VAD (vancristin, adriamycin + dexamethasone) if fit.
supportive -
analgesia, bisphosphonates, local radiotherapy etc
124
what is the most likely causative organism in a case of septic arthritis? where does it come from?
staph aureus - from pneumonia or skin infection
125
give 3 clinical features of septic arthritis
hot, swollen, painful and immobile joint, can affect more than one joint
126
give 3 risk factors for septic arthritis
underlying joint disease, diabetes mellitus, immunosuppression, renal failure, prosthetic joints, recent surgery, IVDU, >80yo.
127
what investigations would you perform in septic arthritis?
urgent joint fluid aspiration for MC&S ± blood cultures and skin swab
128
before your cultures come back, what antibiotic would you prescribe to treat septic arthritis? if it came back as MRSA +ve, what would you give?
flucloxacillin.
vancomycin for MRSA.
129
what is the main causative organism for osteomyelitis? name 2 others
main - staph aureus.
H influenzae, Salmonella
130
what are the clinical features of osteomyelitis?
fever, local pain, erythema. sinus formation if chronic.
131
how would you investigate osteomyelitis?
CT/MRI or bone scan
132
if a patient with sickle cell anaemia presented with osteomyelitis, what organism would you suspect?
salmonella
133
how would you treat osteomyelitis?
flucloxacillin + immobilisation of joint + fusidic acid
134
name 2 bisphosphonates. what are they used to treat?
alenronate, zoledronate, disodium pamidronate.
used for osteoporosis, severe hypercalcaemia of malignancy, myeloma and breast cancer bone metastases to reduce pathological fractures.
135
how do bisphosphonates work?
reduce bone turnover by inhibiting osteoclasts and promoting apoptosis.
reduce bone loss and improve bone mass.
136
what class of drug is allopurinol? how does it work?
xanthine oxidase inhibitor.
blocks metabolism of xanthine (produced from purines) to uric acid.
results in lower plasma uric acid concentrations and reduces precipitation of uric acid in the joints or kidneys.
useful in gout and to prevent kidney stones.
137
how does cholchicine work?
GOUT.
inhibits microtubule polymerisation by binding to tubulin, which is essential for mitosis.
also inhibits neutrophil motility and activity, which leads to a net anti-inflammatory effect which is useful for acute attacks.
138
how does methotrexate work as a treatment for rheumatoid arthritis?
inhibits dihydrofolate reductase, which converts dietary folic acid to tetrahydrofolate (FH4), which is required for DNA and protein synthesis.
lack of FH4 prevents cellular replication.
also has anti-inflammatory and immunosuppressive effects, mediated by IL-6 and -8 and TNF-alpha.
139
what aminosalicylate is a treatment option for rheumatoid arthritis and how does it work?
sulfasalazine - DMARD.
releases 5-ASA, which has anti-inflammatory and immunosuppressive effects.
140
what is strontium ranelate used to treat?
severe osteoporosis
