MSK pharmacology

Question 1

Non-selectibe COX inhibitors

Answer 1

Aspirin
Ibuprofen
Indomethacin

Question 2

Indomethacin is used mainly for

Answer 2

gout because it blocks urate crystal phagocytosis and ankylosing spondylitis`

Question 3

COX-2 inhibitors

Answer 3

Celecoxib
Etoricoxib
Meloxicam

Question 4

COX-2 don’t have an impact on this important COX-1 mediated process

Answer 4

no impact on Platelet aggregation

Question 5

Acetaminophen is an anti-pyretic but not an

Answer 5

anti-inflammatory. It has central/direct analgesic effects

Question 6

a DMARD that inhibits secondary PMN chemotaxis is

Answer 6

Methotrexate used for RA

Question 7

A DMARD used to inhibit IL-1, IL-2-R production

Answer 7

Cyclosporine

Question 8

Anti-TNF biologics

Answer 8

Etanercept, Infliximab, Adalimumab

Question 9

B cell depleting biologic

Answer 9

Rituximab

Question 10

short duration steroids

Answer 10

hydrocortisone
cortisone
prednisone

Question 11

intermediate duration steroids

Answer 11

triamcinalone

Question 12

long acting steroids

Answer 12

dexamethasone

Question 13

What treatment of gout inhibits microtubule aggregation which thereby disrupts leukocyte chemotaxis and phagocytosis

Answer 13

Colchicine

Question 14

Why is indomethacin given for gout?

Answer 14

It blocks urate crystal phagocytosis

Question 15

What drug reduced urate productio by blocking the conversion of xanthine to uric acid

Answer 15

Allopurinol

Question 16

What class of drugs increases the renal clearance of uric acid

Answer 16

Uricosuric drugs

Question 17

What class is Probenacil and what does it do?

Answer 17

Uricosuric drug that inhibits tubular reabsorption of or uric acid thereby increasing the renal clearance of uric acid

Question 18

What’s an example of a true opioid?

Answer 18

Morphine

Codeine