MSK: infection bones/joints, shoulder/elbow, clinical assessment Flashcards
What is the more common type of osteomyelitis?
Non-specific
Who does acute osteomyelitis usually affect?
Children
Boys
What predisposes someone to acute osteomyelitis?
History of trauma Other disease (diabetes, rheum arthritis, immune)
How can acute osteomyelitis spread?
Haematogenous spread
Local spread from site of infection
Secondary to vascular insufficiency
What might be the source of acute osteomyelitis in an infant?
Infected umbilical cord
What might be the source of acute osteomyelitis in children?
Boils, tonsillitis, skin abrasions
What might be the source of acute osteomyelitis in adults?
UTI
Arterial line
What might be the organism involved in acute osteomyelitis in children?
Staph aureus
Strep pyogenes
Haemophilus influenza
What might be the organism involved in acute osteomyelitis in infants?
Staph aureus
Group B strep
E coli
What might be the organism involved in acute osteomyelitis in adults?
Staph aureus
Coagulase neg staph
Mycobacterium tb
Pseudomonas aeroginosa
What might be the organism involved in acute osteomyelitis in those with diabetic foot/pressure sores?
Mixed infection including anaerobes
Which part of the bone does acute osteomyelitis usually affect first?
Metaphysis
What is the pathology of acute osteomyelitis?
Acute inflammation and necrosis of bone, new bone formation
What are the clinical signs of osteomyelitis in an infant?
Failure to thrive Drowsy/irritable Metaphyseal tenderness + swelling Decrease ROM Positional chance Around knee
What are the clinical signs of osteomyelitis in a child?
Severe pain Reluctant to move, non weight-bearing Tender fever (swinging pyrexia) Tachycardia Malaise Toxaemia
What are the clinical signs of osteomyelitis in an adult?
Seen in thoracolumbar spine
Backache
History: UTI/urological procedure/open fracture/surgery
Elderly, diabetic, immunocompromised
How is acute osteomyelitis diagnosed?
History and clinical exam FBC + diff WBC ESR, CRP Blood cultures U&Es X-ray US Aspiration Isotope bone scan Labelled white cell scan MRI
What are the differential diagnoses of acute osteomyelitis?
Acute septic arthritis
Acute inflammatory arthritis
Trauma
Transient synovitis
Haemophilia/rheumatic fever/sickle cell crisis
Soft tissue infection: cellulitis, necrotising fasciitis, TSS
How many days until periosteal changes seen on XR?
10-20 days
What is sequestrum?
Piece of dead bone become separated during process of necrosis from normal bone
When is it called when late osteonecrosis happens in acute osteomyelitis?
Sequestrum
When is it called when late periosteal new bone happens in acute osteomyelitis?
Involucrum
What are some labels used in scans for acute osteomyelitis?
Technetium-99m labelled diphosphonate
Gallium 67 citrate delayed imaging
Indium-111 labelled WBC scan
What is the microbiological diagnosis of acute osteomyelitis?
Blood cultures
Bone biopsy
Tissue or swabs at 5 sites (prosthetic infections)
What is the treatment for acute osteomyelitis?
Supportive - pain and dehydration
Rest and splintage
Antibiotics
How long would someone be on antibiotics for acute osteomyelitis?
4-6wks (depends on response)
What anitbiotics usually used for acute osteomyelitis?
Fluclox + BenzylPen
Why might antibiotics not work in acute osteomyelitis?
Drug resistance Bacterial persistence (dormant) Poor host defences Poor drug absorption Drug inactivation by host flora Poor tissue penetration
When would surgery be indicated for acute osteomyelitis?
Aspiration of pus Abscess drainage Debridement Refractory to non-operative Rx Infected joint replacement
What are the complications of acute osteomyelitis?
Septicemia Death Metastatic infection Pathological fracture Septic arthritis Altered bone growth Chronic osteomyelitis
How might someone get chronic osteomyelitis?
Follow acute osteomyelitis
De novo - after op, following open fracture, immunosuppressed, diabetics, elderly, IVDU
Repeated breakdown ‘healed’ wounds
What organisms are involved in chronic osteomyelitis?
Mixed Staph aureus E.coli Strep. pyogenes Proteus
What is the pathology of chronic osteomyelitis?
Chronic inflammation: cavities, dead bone (sequestra), involucrum
What are the complications of chronic osteomyelitis?
Chronically discharging sinus+flare ups Ongoing (metastatic) infection Abscesses Pathological fracture Growth disturbance+deformities Squamous cell carcinoma
What is the treatment for chronic osteomyelitis?
Long term antibiotics (local - gentamicin cement/beads, collatemp or systemic) Eradicate bone infection - surgery Treat soft tissue problems Deformity correction Massive reconstruction? Amputation?
What are the possible routes of infection for acute septic arthritis?
Haematogenous
Eruption of bone abscess
Direct invasion