MSK/Derm VI Flashcards
impetigo
superficial skin infection
staph aureus
strep pyogenes
honey color blister
bullous - caused by staph aureus
cellulitis
infection deep dermis and subQ
strep pyogenes
staph aureus
erysipelas
infection - upper dermis and lymphatics
strep pyogenes
well defined demarcation infected and normal skin
abscess
often staph auresus - methicillin resistant
necrotizing fasciitis
deep tissue injury
strep pyogenes
crepitus - methane and CO2 production
staph scalded skin syndrome
destroy keratinocyte attachment in stratum granulosum only
fever, rash, sloughing upper layers epidermis
newborn and children
toxic epidermal necrolysis
destroys epidermal-dermal jxn
herpes skin infection
HSV1 and 2
finger - whitlow
molluscum contagiosum
umbilicated papule - poxvirus
hairy leukoplakia
white painless plaque tongue - cannot scrape off
EBV mediated
leukoplakia
not hairy
on side of tongue
is precancerous
thrush
oral through - scrapable
pemphius vulgaris
IgG Ab - desmoglein - of desmosome
intraepidermal bullae - acantholysis
positive nikolsky sign - separation with stroking
IF - Abs around epiermal cells in reticular pattern
bullous pemphigoid
IgG Ab - hemidesmosome - basement membrane
tense blister - with eosinophils
IF - linear pattern - epidermal/dermal junction
negative nikolsky sign
dermatitis herpetiformis
extensor surfaces
IgA - at tip of dermal papillae
celiac association
erythema multiforme
infection, drug, cancer, autoimmune disease
SJS
fever, bulla, necrosis, sloughing skin, high mortality
often mucous membranes
adverse drug rxn
toxic epidermal necrolysis
> 30% of body surface
severe SJS
fever, bulla, necrosis, sloughing skin, high mortality
acanthosis nigricans
flexor region
-hyperpigmented
hyperinsulin
visceral malignancy
actinic keratosis
premalignant
to SCC - proportional risk to degree of epithelial dysplasia
erythema nodosum
inflammation of subQ fat - anterior shins
sarcoid, coccidio, histo, TB, strep, leprosy, crohn
pityriasis rosea
heraly patch - followed by christmas tree distribution
self resolving 6-8 weeks
sunburn
UVA - tanning and photoaging
UBV - sunburn
BCC
MC skin cancer
rare mets
pink pearly nodule
or flat nonhealing ulcer
palisading nuclei
SCC
2nd MC skin cancer
precursor - actinic keratosis
keratoacanthoma
variant SCC - grows rapidly but may regress
melanoma
risk of mets
S-100 tumor marker
sun exposure
depth of tumor - risk of mets
ACBDE
D - 6mm
types of melanoma
sueprficial spreading
nodular
lentigo maligna
acral lentiginous
vemurafenib
BRAF kinase inhibitor
benefit in nonrescetable melanoma with BRAF V600E mutation
