MSK/Derm V Flashcards

1
Q

polymyositis

A

progressive symmetric prox muscle weakness

endomysial inflammation with CD8 T cells

tx - immunosuppression

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2
Q

elevated CK, positive ANA, anti-Jo1, anti-SRP, anti-Mi-2 Abs

A

polymyositis

dermatomyositis

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3
Q

dermatomyositis

A

gottron papules
heliotrope rash, shawl and face rash, mechanics hands

perimysial inflammation and atrophy with CD4 cells

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4
Q

myasathenia gravis

A

autoAb - ACh receptor

worsen with use

associated - thymoma and thymic hyperplasia

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5
Q

lambert eaton syndrome

A

autoAb presynaptic Ca channel

decreased ACh release

prox muscle weakness
autonomic sx
improve with muscle use

association - small cell lung cancer

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6
Q

tx of myasthenia gravis

A

AChE inhibitor reverse sx

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7
Q

myositic ossificans

A

metaplasia - skeletal m into bone
-after muscular trauma

suspicious mass or incidental finding on Xray

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8
Q

scleroderma

A

systemic sclerosis

autoimmune
non-inflammatory vasculopathy
collagen deposition

2 types

  • diffuse
  • limited
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9
Q

diffuse scleroderma

A

Scl-70 Ab - anti DNA topoisomerase I

widespread skin involved
rapid progression
early visceral involvement

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10
Q

limited scleroderma

A

limited skin involvement - finger and face

CREST
calcinosis
raynaud
esophageal dysmotility
sclerodactyly
tenalgiectasia

anti-centromere Ab

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11
Q

skin layers

A

epidermis
dermis
subQ

surface to base:
stratum corneum - keratin
stratum lucidum
stratum granulosum
stratum spinosum - desmosomes
stratum basale - stem cells
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12
Q

zona occludens

A

tight junctions

claudins and occludins

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13
Q

zonula adherens

A

adherens junction

below tight

form belt - connect actin of adjacent cells

Ca dependent

cadherin - lost in mets

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14
Q

desmosome

A

macula adherens

keratin structural support

Abs - pemphigus vulgaris

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15
Q

gap jxn

A

connexon - with central channel

permit communication cell to cell

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16
Q

hemidesmosome

A

connect keratin in basal cell to BM
-basolateral surface

autoAb - bullous pemphigoid

17
Q

integrins

A

maintain basolateral membrane - binding collagen and laminin

18
Q

macule

A

flast lesion

19
Q

patch

A

macule >1cm

20
Q

papule

A

elevated solid

21
Q

plaque

A

papule >1cm

psoriasis

22
Q

vesicle

A

fluid containing blister

23
Q

bulla

A

blister >1cm

24
Q

scale

A

flaking stratum corneum

25
crust
dry exudate impetigo
26
eczema
atopic dermatitis itchy eruption
27
intradermal nevi
papular
28
junctional nevi
flat macule
29
auspitz sign
pinpoint bleed from exposure of dermal papilla when scales ripped off with psoriasis
30
psoriasis
acanthosis and parakeratotic scaling more stratum spinosum less stratum granulosum
31
rosacea
erythematous papules and pustules no comedones chronic change - rhinophyma - bulbous deformation of nose
32
seborrheaic keratosis
flat greast pigmented squamous epithelium keratin filled cysts - horn cysts looks stuck on
33
leser trelat sign
sudden appearance multiple seborrheaic keratosis indicated underlying malignancy
34
verrucae
warts - from HPV epidermal hyperplasia hyperkeratosis koilocytosis condyloma actuminatum - on genitals