MSK antibodies & path 2

Question 1

MCTD major antibody?

Answer 1

U1-RNP (spliceosome component)

Question 2

antibody that predicts poor prognosis for scleroderma

Answer 2

anti-topiosomerase I

Question 3

specific test for RA

Answer 3

anti-CCP

Question 4

Enchondroma - where?

Answer 4

small distal bones of hands and feet

increased risk for chondrosarcoma

Question 5

most common bone tumor in women

Answer 5

giant cell tumor (osteoclasts) - epipheseal plate

Question 6

osteoblastoma

Answer 6

larger osteoid osteoma in males, vertebral column

interlacing trebeculae of woven bone

Question 7

most common benign tumor

Answer 7

osteochondroma

Question 8

can affect the face and skull (Gardner’s syndrome)

Answer 8

Osteoma

Question 9

only bone tumor more common in adulthood

Answer 9

chondrosarcoma

resistant to chemotherapy
may arise from enchondromas or osteochondromas
can metastasize to the lungs

Question 10

Ewing sarcoma - overexpression of?

Answer 10

MIC2

t(11;22)

Question 11

Ewing radiograph

Answer 11

onion-peel periosteal reaction

Question 12

Most common primary bone tumor; production of osteoid / metasphysis

Answer 12

Osteosarcoma

Question 13

moth-eaten appearance & periosteal sunburst rnx - elevation of the periostium known as…
(osteosarcoma)

Answer 13

Codman’s triangle

Question 14

RA HLA type?

Answer 14

HLA-DR4

Question 15

Seronegative Sponylitis

Answer 15

HLA-B27

Question 16

synovial hypertrophy in RA

Answer 16

pannus

Question 17

hyperextend the PIP, DIP flexion

Answer 17

swan neck

Question 18

hyperflex the PIP and DIP extension

Answer 18

boutonniere

Question 19

osteopetrosis defect

Answer 19

marble bone disease
failure in the osteoclasts
AR in infants - BMT by age 4

Question 20

syndrome seen mostly in young girls

fibrous dysplasia, precococious puberty, cafe-au-lait skin spots

Answer 20

McCune-Albright syndrome

Question 21

If pseudogout in pt <50 y/o, look for?

Answer 21

hemochromatosis

hyperparathyroidism

Question 22

specific antibodies for lupus

Answer 22

Anti-dsDNA, anti-smith

Question 23

antibodies that can cause hyper-coaguable state

Answer 23

anti-phospholipid

Question 24

antibodies that are correlated to increased risk of heart block

Answer 24

anti-Ro

Question 25

erythema nodosum, hilar lymphadenopathy, arthritis

Answer 25

Lofgen syndrome

~sarcoid

Question 26

Diffuse scleroderma

Answer 26

anti-scl70 (anti-topiosimerase) and RNA Pol III

Question 27

Limited scleroderma (CREST)

Answer 27

anti-centromere antibody

Question 28

Force-velocity relationship

Answer 28

isotonic twitch

Question 29

Length-tension relatioship

Answer 29

isometric

Question 30

protein released by osteoclasts, which degrades Type I and II collagen

Answer 30

cathepsin K

Question 31

Composition of Bone:
2/3 -
1/3 -

Answer 31

2/3 = hydroxyapetite 
1/3 = Type I Collagen & Non-collagenous proteins

Question 32

Vit D Dependent Rickets I

Answer 32

Autosomal Recessive Defect in 1-alpha-hydroxylase

Question 33

Vit D Dependent Rickets II

Answer 33

AR defect in receptor for 1,25 dihydroxyvitamin D

Question 34

Vit D Resistant Rickets

Answer 34

Hypophosphatemia, decreased reabsorption of phosphate, lower limb deformities, stunted growth

Question 35

Antibody for Rx-induced lupus

Answer 35

Anti-histone

Question 36

antibody that increases risk of sceleroderma renal crisis

Answer 36

Anti-RNA-Poly 3