MSK

Question 1

Signs and symptoms of lupus

Answer 1

Skin - photosensitivity, malar rash, vasculitis
Nervous - migrane, epilepsy etc (loads)
Lungs - fibrosis, pleural effusion, pleurisy
Kidney - glomerlonephritis
Heart - pericarditis, myocarditis, aortic valve lesions, thrombosis, accelerated athersclerosis

High BP (bc on nephritis)
Fatigue, malaise, depression

Question 2

Blood results of lupus

Answer 2

ANA
APA (phospholidid)
?RF
Anemia (antibody against RBCs)
Pancytopenia (bc of activity at tissues)

Question 3

Uveitis is associated with what MSK diseases

Answer 3

Ank Sponds - usually iritis .

Can identify by irregular pupil, or small pupil

Question 4

Scleritis is associated with what MSK disease

Answer 4

Rheumatoid. Can identify by normal iris but inflammed, red sclera. If severe with be necrotising.

Question 5

What is rheumatoid factor an auto-antibody against

Answer 5

The Fc region of IgG

Question 6

Iritis is associated with which MSK condition

Answer 6

Spondyloarthropathies

Question 7

Scleritis is associated with which MSK condition

Answer 7

Rheumatoid - necrotising is the worst

Question 8

Signs of iritis vs scleritis vs uveitits

Answer 8

Iritis - irregular pupil, or small pupil
Scleritis - red sclera, iris and pupil normal
Uveitits - iris, sclera & choroid involvement

Question 9

IBD (crohn’s and ulcerative colitis) are associated with which MSK condition and what is this called

Answer 9

Associated with spondyloarthropathies
Enteropathic arthritis - can overlap with any others of the spondyloarthropathies, so pts with IBD may develop ankylosing spondylitis, psoriasis, uveitis, reactive arthritis, or if they are young, juvenile idiopathic arthritis