MSK 3: Injury and Healing Flashcards

1
Q

What are the 3 mechanisms of bone fracture?

A

Stress
Trauma
Pathological

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2
Q

What is the difference between pathological and stress fractures?

A

Pathological is normal stresses on abnormal bone, stress is abnormal stress on normal bone.

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3
Q

What terms are used to describe soft tissue integrity in fractures?

A

Open

Closed

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4
Q

What is a greenstick fracture?

A

The fracture is not complete in the bone.

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5
Q

What is a comminuted fracture?

A

The bone is broken into many bone fragments

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6
Q

What is the name given to a bone with one complete break, with no fragments?

A

Simple fracture

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7
Q

In what ways can a fracture be displaced?

A

Transverse
Spiral
Impacted

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8
Q

What is the process of a stress fracture developing?

A
  • Overuse
  • Stress exerted on bone is greater than bone’s capacity to remodel.
  • Bone weakening
  • Stress fracture
  • Risk of complete fracture
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9
Q

What are the factors of of female athlete triad?

A

Disordered eating
Amenorrhea
Osteoporosis

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10
Q

Give examples of causes of pathological fractures?

A
Osteoporosis
Malignancy
Vit D deficiency
Osteomyelitis
Osteogenesis imperfecta
Paget's disease
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11
Q

What is osteoporosis?

A

Disrupted bone microarchitecture due to increased osteoclast activity over osteoblast.

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12
Q

Is osteoporosis more common in males or females?

A

Females (4:1)

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13
Q

What are three causes of secondary osteoporosis?

A

Hypogonadism
Glucocorticoid excess
Alcoholism

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14
Q

What kind of bone fractures are associated with osteoporosis?

A

Fragility fractures from low energy trauma

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15
Q

What are some examples of primary bone cancers?

A

Osteosarcoma
Chondrosarcoma
Ewing sarcoma
Chordoma

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16
Q

How can cancers that are not primarily in the bone affect bones?

A

Metastases from breast, prostate, kidney, thyroid or lung cancer.

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17
Q

What condition does vitamin D deficiency cause in adult and children’s bones?

A

Osteomalacia and rickets

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18
Q

What are causes of vitamin D deficiency and related bone conditions?

A
Inadequate sun exposure
Malabsorption 
Liver disease
Renal disease
Receptor defects
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19
Q

What is ‘brittle bone disease’?

A

Osteogenesis imperfecta
Am autosomal dominant or recessive conditon of reduced type 1 collagen due to decreased secretion and production of abnormal collagen, resulting in insufficient osteoid production.

20
Q

What is pagets disease?

A

Ecessive bone breaking with disorganised remodelling, causing deformities, pain, fractures and athritis.

21
Q

What are the four stages of pagets disease?

A
  • Osteoclast activity
  • Mixed osteoclastic-osteoblastic activity
  • Osteoblastic activity
  • Malignant degeneration
22
Q

In week 1 post-fracture what happens in the healing process?

A

Heamatoma formation
Cytokine release
Granulation tissue forms

23
Q

Between week 2-4 what happens in the healing process?

A
Soft callus (fibrocartilage) formation 
New blood vessels are formed
24
Q

Within 1-4 months of a bone fracture what occurs in the healing process?

A

The soft callus is converted to bone.

25
Q

Within 4-12 months of a fracture what happens in the healing process?

A

The callus responds to activity, external forces, functional demands and growth.
Excess bone is removed.

26
Q

What is primary bone healing?

A

Intramembranous healing providing absolute stability.

e.g with plates and screws (no movement)

27
Q

What is secondary bone healing?

A

Endochondral healing involving responses in the periosteum and external soft tissues, providing relative stability.

28
Q

When are signs of healing visible of x-rays?

A

7-10 days

29
Q

What are the three main stages of fracture management?

A

Reduce
Hold
Rehabilitate

30
Q

What are the two types of reduction, and examples of each?

A

Open: mini-incision or full exposure
Closed: manipulation or traction (skin or skeletal)

31
Q

What are the options for hold?

A

Closed: plaster or traction

Fixation

32
Q

What are some examples of fixation?

A

Internal: intermedullary (pins/nails) or extramedullary (plates/pins)
External: Monoplanar or multiplanar

33
Q

What are the stages of rehabilitation?

A

Use (pain-relief and retrain)
Move
Strengthen
Weight-bear

34
Q

What considerations should there be when deciding treatment?

A
Displaced?
Stable?
At the joint surface?
Soft tissue integrity?
Other illnesses?
Patients wishes?
35
Q

What is tendinosis?

A

Abnormal thickening of tendons

36
Q

What is tendinitis?

A

Inflammation of tendons

37
Q

In addition to abnormal thickening and inflammation, what could also happen to tendons if a fracture is displaced?

A

Rupture

38
Q

What does a ‘Grade I’ ligament injury suggest?

A

Slight incomplete tear with no notable joint instability.

39
Q

What does a ‘Grade II’ ligament injury suggest?

A

Moderate/severe incomplete tear with some instability.

40
Q

What does a ‘Grade II’ ligament injury suggest?

A

Complete tearing of 1 or more ligaments with obvious instability.

41
Q

What are the stages of ligament healing and their time frame?

A
Inflammatory phase (1-7 days)
Proliferation phase (7-21 days)
Remodelling (>14 days)
Maturation (weeks to years)
42
Q

What is the pathology of inflammatory phase?

A

Fibrin clot formed in ligament tears.

43
Q

What is the pathology of proliferation phase?

A

Tendons and ligaments are weakest, tensile strength builds

44
Q

What is the pathology of remodelling?

A

Tendons and ligaments heal with scar tissue that reduces ultimate strength and causes adhesions.

45
Q

What factors affect tissue healing?

A

Mechanical environment: movement and forces

Biological environment: Blood supply, immune function, infection, nutrition.

46
Q

What are the benefits of mobilisation on injured ligamentous tissue?

A

Scars are wider, stronger and more elastic

Better alignment/quality of collagen

47
Q

What are the bad effects of immobilisation of injured ligamentous tissue?

A

Less strength of scar
Protein degradation exceeds synthesis in collagen
Production of inferior tissue by blast cells
Resorption of bone at site of ligament insertion
Build tissue tensile strength