MSK Flashcards
What is Paget’s disease of the bone
Osteitis deformans
- increased bone turnover
- disorganise remodelling, deformity, weakness
cause of Pagets disease of the bone
- genes- SQSTM1, RANK
- viral- RSV,
sx of pagets disease of the bone
- asx in most
- deep, boring pain
- deformity- pelvis, L spine, femur, tibia, frontal bossing of the skill
- headaches
- pathological #
- OA
- nerve compression
- malignancy, HF, kidney stones
ix ?paget’s
- skeletal XR survery
- bloods - ALP raised, Ca PO4 normal
- **- boneturnover markers in urine
- **- bone scans
tx paget’s
- analgesia
- bisphos- alendronic acid
- calcitonin 3m
- surgery- osteotomy, arthroplasty, # alignment
What is osteomalacia
normal amount of bone, low minerl acontent
causes of otseomalacia
- Vit D deficiency
- CKD- 1,25,dihroxy cholecalciferol deficiency
- liver disease- reduced hydroxylation of Vit D and malabs
- tumour induced- hyperphosphaturia
describe the way in which UV, vitamin D is processed in the body and used
- UV on skin causes 7-dehydrocholesterol to be converted to pre- vit D3
- pre- vit D3 is converted into cholecaliferol (vit D3)
- vit D3 and D2 are eaten via supplements, fish and meat
- Vit D3 is converted in 25-hydoxyvitD3 in LIVER
- KIDNEYS release 1alpha hydroxylase, whihc converts hydroxy vit D3 into 1,25-dihydroxyvitmain D ie calcitriol
what does calcitriol do
ie 1,25-dihydroxycholecalciferol
INCREASES SERUM CA
- increases Ca absorption in gut
- increases reabs of Ca in kidneys
- increases bone breakdown (osteoclasts)
presentaiton of osteomalacia
- rickets
- hypocalcaemia- confusion, numbness, spasms, seizure, MI
- bone pain
- pathological #
- proximal myopathy- waddling
ix osteomalacia
bloods- hypoCa, hypophosphataemia, increased ALP and PTH, decreased vit D
XR- loss of cortical bone, #
bone biopsy- poor mineralisation
management of osetomalacia
- vit D
- Ca
- calcitriol
- phsophate
What is oeseoporosis
- low bone mass and microarchitectural deterioration-
- thinned, disconnected trabeculae
causes of OP
- inflammation- cytokines increase bone resorp
- endocrine- hyperthyroid, Cushing’s, steroids,
- oestrogen/testosterone
- poor skeletal loading (immobility, low body wt)
ix OP
- FRAX score- 10 yr prob of hip/bone #
- dual energy XR- t-score
what are the cut offs and definitions of a T-score
> -1 = normal
-1 to -2.5= Osteopenia
< -2.5 = OP
< -2.5 + # = severe OP
Management of OP
Cause
- HRT in early menopause/hysterectomy
- control thyroid
- control inflammatory conditions
Bisphosphonates
- alendronate PO, Zoledronate IV
- Denosumab- monoclonal antibody to RANKL- blocks bone resorption
- Teriparatide-
- synthetic PTH analogue, daily injection
- increases osteoblast activity and bone formation (dont think too hard about it)
what instructions do you give some taking oral alendronic acid
- dont lie down for 30min after
- have with water
- get dental appt before taking- linked with osteonecrosis of the jaw
what is osteogenesis imperfecta
- disorder of type 1 collagen
- brittle , fragile bones
- bone heals with deformity
types of osteogenesis imperfecta
Type 1- least severe
Type 3- severe, pogressively deforming
presentation of oesteogenesis imperfecta
- #
- bowing of long bones
- blue sclera
- hearing loss
- short stature, scoliosis
- ***- ligamentous laxity– hyperextensible joints
ix ?osteogenesis imperfecta
- foetal USS_ only picks up severe, type 3
- bloods- ALP raised
- genetic testing
- skin biopsy- assess collagen
- bone biopsy
- XR
Management of osteogenesis imperfecta
- Ca
- bisphosphonates
- synthetic calcitonin (opposes PTH, usually produced by thyroid)
- intramedullary rods to prevent bowing
What is Scheuermann’s disease
- slow growth of anterior spine
- leads to kyphosis, deformity
management of scheuermann’s
- lifestyle- physio, back braces
- surgery to manage pain
what is osteopetrosis
- inherited
- increased bone density and abnormal growth
sx osteopetrosis
- neonatal bone marrow failure , pancytopenia
- incidental findings on XR
- #
- short stature
- nerve compression
- hypocalcameia- confusion, seizures, spasms
management of osteopetrosis
- vit D
- EPO/bone marrow transplant
- surgery
what is achondroplasia
- autosomal dominant
- overproduction and deposition of collagen
- cartilage does not harden to bone on grwth plate
sx achondroplasia
Deformity
- dwarfism- short, enlarged head, frontal bossing
- kyphosis, lordosis
- leg bowing
management of achondroplasia
- GH therapy
- limb lengthening surgery- controversial
OA sx
- painful joints- stiffness
- worse with activity
- srepitus
- herberdens and bouchards nodes
ix oA
XR Loss of joint space Osteophytes Subchondral sclerosis Subchondral cysts
- bloods- bone profile (Ca, D, PO4, ALP- normal
- diagnostic injeciton
- arthroscopy
tx OA
- lifestyle- physio, wt loss, footwear
- ibuprofen gel
- analgeisia
- steroid intra-art injections
- DMARDS- if inflam element
- surgery- arthroplasty, fusion
RA sx
- symmterical, deforming, polyarthropathy
- swan neck (hyperextension PIP, flexion DIP)
- Boutonniere- flexion PIP, hyperextension DIP)
- ulnar deviation
- joint pain and stiffness worse in morning/inactivity , >30min
- swollen, red hot joint in flare
- fatigue, malaise, wt loss
Extra artiuclar
- Lungs- nodules, fibrosis= caplans syndrome
- skin- nodules, rashes, vasculitis
- **- eyes- sjogrens, scleritis/episcleritis
- **- neuro- peripehral neuro
- CVS- CVA, endocarditis/pericarditis/ CVD
- OP (cytokines increase bone turnover)
- *- glomerulonephritis
- *- hepatitis
ix ?RA
- CRP/ESR
- Anti-nuclear antibodies, RF, Anti-cyclic citrullinated peptide
XR Loss of joint space *Erosion of joint Subchondral sclerosis *Soft tissue swelling
- CXR if ?lung involvement
- MSU if ?renal involvement, echo
when to urgently refere RA
- small joints in hands/feet
- > 1 joitn affecte
- delay in >3m between onset of sx and seeking medical advice
management RA
- smoking cessation
- walking aids, splints, physio, OT
- bridge DMARD with steroid
1. DMARD- methotrexate or sulfasalazine, or hydroxychloroquine
2. combination DMARDs
3. biological DMARDS +methotrexate - infliximab, rituximab, abatacept, tocilizumab - surgery to improve function and prevent deformtiy
what monitoring is there of RA
- CRP until remission/low-activity disease
what crystals are involved in gout
- urate- purine breakdown pyproduct
causes of gout
Hyperuricaemia
- high purine diet
- drugs
- renal failure
- genes
Underexcretion of urate - alcohol - Renal impairement genes - ****diuretics, aspirin, anti-TB, lead
Overproduction of urate
- myeloproliferative
- ***CT
- **psoriasis
sx gout
- acute (overnight)- severe joint pain
- hallux MTP most commonly
- red, swollen joint
- reduced ROM
- tophi- aggregates, go in 2 years
ix ?gout
hx- meds, wt, HTN, alcohol
- bloods- UE, urate (NOT diagnostic)
- XR- effusion, punched out lesions (rat bites)
- synovial fluid aspiration polarised light micro
what do crystals look like in gout on synovial fluid aspiration, polarised light micro
- negatively birefringent needles
tx acute gout
Acute
- NSAID, PPI
- Colchicine
- *- aspiration
- *- IA steroid injection
- *- PO steroids
tx gout LT
Chronic
- Allopurinol/febuxosat (xanthine oxidase inhibitors)– give >2w post latest attack, monitor UEs
- co-prescribe colchicine at 1st as can cause flare in uric acid in 1st w
- never give with azathioprine- can cause reaction
- diet– reduce beer, purine high foods (fish, meats)
what crystals cause pseudogout
Ca pyrophosphate
sx pseudogout
- monoarthritis
- severe pain
- stiffness, swelling
- +-fever
trigger
trigger of gout/pseudogout
- trauma to joint
- dehydration
- illness
- post surgery
- endocrine/metabolic disorder
ix ?pseudogout
- XR_ chondrocalcinosis
- synovial aspiration- polarised light micro
- iron studies, bone profile, Mg
what ye see on polarised light microscopy for pseudo gout
positively birefringent rhomboids
management of pseudogout
- NSAIDs, PPI
- Colchicine
- arthrocentesis
- ***- IA steroid
- **- trial anti-rheumatic drug- hydrocychloroquine, methotrexate
- **- synovectomy, surgery
- physio
what causes juvenile gout
Lesch-Nyhan Syndrome
- genetic X linked
- enzyme deficiency
- build up of uric acid
What are seronegative spondyloarthropathies
- a group of conditions
- associated with HLAB27- human leukocyte antigen
- will NOT test positive for RF (seronegative)
- unknown disease mechanism
What are the seronegative spondyloarthropathic conditions?
- Ankylosing spondylitis
- Psoriatic Arthritis
- Enteropathic arthritis
- Reactive arthritis (Reiter’s)
- ## Junvenile idiopathic arthritis
sx of ank spond
- stiffening and fusion of the spine (reduced neck movements, twisting, chronic flexion)
- pain in ilio-scaral joint
- alternating buttock pain
- *- stiffness- worse in morning
- insidious onset
- *- dactylitis
- *- enthesitis- achilles, elbow, knee, costochondritis
- *- spinal # predisposition
- *- iritis/anterio uveitis
- lung fibrosis (apical)
- aortic regurg, AV node block
- *- amyloidosis
- other AI cnoditions
- fatigue wt loss
ix for ?ankylosing spondylitis
- o/e- tenderness over spine/iliosacral joints, reduced lateral flexion, schober’s positive (foward flexion), reduced chest expansion
- FBC- normocytic anaemia of chronic disease
- CRP/ESR
- RF negatvie
- XR spine- bamboo
- MRI- oedema
- *- DEXA- OP
- *- genetics- HLAB27
Management of ank spond
- smoking cessation
- physio, hydrotherapy, exercise
- NSAIDs, paracetemol, codeine
- anti-TNF biologics- etanercept, adalimumab
- steroid injections- ST relief of flares
- surgery- vertebral osteotomy to correct deformity
what proportion of psoriatic patients are affected by psoriatic arthritis
15%
sx of psoriatic arthritis
- large joint oligoarthritis
- DIP arthritis
- pain
- arthritis mutilans- floppy fingers poiting in wrong directions, osteolysis, telescoping, no pain anymore
- *- dactylltis- v. painful
- psoriasis- extensor surfaces
- genital , scalp and belly button psoriasis
NAILS - in 80%
- moth eaten looking
- onycholysis- lifting off, thickened, creamy
ix for ?psoriasis
- psoriasis epidemiological screening tool
- bloods- anaemia of chronic disease, CRP/ESR, RF -ve
- XR- DIP erosion (pencil in cup), periostitis, ankylosis, osteolysis
- MRI- dtects early changes
- HLA27
tx ank spond
- NSAID
- steroid injections
Immunosups (same as RA
1. DMARD- metho, ciclosporin, sulfalazine
2. 2x DMARD
3. Metho + anti-TNF (etanercept, infliximab, adalimumab
-
What is enteropathic arthritis
- arthritis associated with IBD
sx enteropathic arthritis
- sacroilitis
- peripheral arthritis- commonly symmetrical
- enthesitis (tendon/ligament insertion pain)
- GI sx
management of enteropathic arthritis
- treat IBD (pred/hydrocortisone (IBD), aminosalicylate (UC) methotrexate, azathioprine)
- DMARDs- methotrexate, azathioprine
What is reactive arthritis
- GI (salmonella, shigella) or STIs (chlamydia) trigger sterile inflammation of synovial membrane/fascia/tendons
- higher incidence in those with psoriasis
sx of reactive arthritis
- GI sx
- STI sx
Cant see, wee, climb a tree Arthritis: - sacroilitis, spondylitis - datylitis - enthesitis
Eye
- conjunctivitis
- iritis
- urethritis
- balanitis
skin- brownish scaling on palms/soles (keratoderma blennorrhagica)
ix ? reactive arthritis
- ESR/CRP,
- *- RF negative
- aspirate joint to exclude crystals, septic
- stool culture, urethral/vagina swab
- *+- XR/**MRI
- *- HLA b27
tx reactive arthritis
NSAIDs
- IA steroid injection
- recurrent cases- DMARD (sulfalazine, anti-TNF)
presentation of juvenile idiopathic arthritis
- Gradual Onset
- stiffness, pain after rest
- limp
- ant. uveitis (may be presenting sx)- photophobia, redness, tearing, blurring, floaters
- malaise, irritability, rash, fever, wt loss
- may have hx of sore throat, URTI, prev. infection
- fam hx of HLAB27 sx (iritis, arthritis, psoriasis)
diagnosis of junveline idiopathic arthritis
Of exclusion- rule out:
- septic arthritis (joint aspiration)
- reactive arthritis (swab/urine, stool)
- *- trauma (XR)
- *- malignancies (leukaemia, bone) (XR, FBC)
- ‘Juvenile’ <16yo
- idiopathic- no cause found
- arthritis- join swelling/painful restriction >56w
ix
- bloods- anaemia, ESR/CRP,
- antibodies (RG, ANA, anti-ccp)- negative
- infection screen, joint aspirate
- STI swabs, Stool culture
- XR, MRI
management of juvenile idiopathic arthritis
- NSAIDs, analgesia
- methotrexate
- corticosteroids (avoid if poss- growth, OP)
- biologics- TNFa, IL-6 blocker (tocilizumab)
complications of junvenile idiopathic arthritis
- increased BF due to inflammation–> bone overgrowth–> limp/deformity
- joint destruction needing replacement early
- *- severe visual impairment from uveitis
- *- anaemia of chronic disease
- *- OP
- growth failure
What is the pathophysiology of systemic lupus erythematosus
- multisystem autoimmune condition
- type 3 hypersensitivity
- immune complex formation
- these deposit in organs
- immune complex mediated inflammation–> tissue damage
key sx in presentation of SLE to look out for
- malar/butterfly rash (in 1/3)- across nose, cheeks, defined boarders
- discoid rash- scarring
- levedo reticularis- mottled skin
- photosensitivity- disease made worse by UV
other sx of SLE (not key)
- sicca- dry eyes/mouth
- *- oral ulcers
- alopecia
- resp- SOB, chest pain (pleuritis, pulm HTN, fibrosis)
- CV- HTN, CVA, raynauds, IHD
- GI- D+V, pain (peritonitis, pancreatitis)
- renal- HTN, renal failure
- *- MSK- arthritis, **tendon rupture
- *- Neuro- meningitis, MG, seizures
- psych issues
- anaemia, thrombocytopenia (bleeding), thrombosis
diagnosis of SLE
- no diagnostic test
- FBC- pancytopenia
- *- coomb’s- haemolytic anaemia
- ESR
- UE- dysfunction, urinalysis
- *- coag
- anti-dsDNA antibody (specific), ANA, RF, **cardiolipin
- CXR, echo, MRI head
management of SLE
- statins, antiHTN, antiplatelets
- skin- sunscreen, topical steroids
- joints- NSAID, IA steroids
MILD- hydroxychloroqiune + NSAID
MODERATE- corticosteroids+ methotrexate/azathioprine, mycophenolate mofetil
SEVERE- corticosteroid +cyclophosphamide, biologics
What is antiphospholipid syndrome
- autoimmune attack on fat molecules
- increase clot risk
sx antiphospholipid syndrome
- thrombosis- DVT, stroke, TIA, MI, PE
- HTN
- **- balance and mobility issues
- ** - vision/speech/memory issues
- parasethesia, migraines
- fatigue
- unexlpained miscarriage, PROM, severe pre-eclampsia
- livedo reticularis- mottled skin
antibodies may be present in antiphosphalipid syndrome
- lupus anticoagulant
- anti-apoliproprotein
- anti-cardiolipin
tx antiphospholipid syndrome
- anticoag/antiplatelets lifelong
- acute - SC heparin
what is systemic sclerosis (scleroderma)
- autoimmune
- microvasc damage
sx systemic sclerosis/scerloderma
CREST
Calcinosis (under skin, esp in fingers- infections, bumpy)
Raynaud’s
oEsophageal dysmotility
Strictures/sclerodactylyl (white fingers)
Telangiectasia
- sx in the systems
ix scleroderma
- ANA
- anaemia of chronic disease (normo)
- ESR
- ix for systems if sx (ECG, echo, CXR, CT, XR)
tx scleroderma/systemic sclerosis
- smoking cessation
- stretch skin to keep ROM, emollient
- raynauds- vasodilators— iloprost, sildenafil, nifedipine
- GORD- omeprazole
- renals- ACEI
- antihistamines for itch
- cyclophosphamide
- methotrexate
- organ transplant
what is sjorgrens
- lymphocytic infiltration of tear and salivary glands
- can coincide with other autoimmune conditions
sx sjogrens
- sicca- dry mucous membranes
- enlarged salivary glands, stones
- cough, dyspareunia, oesophagitis
- systemic features (arthralgia, neuropathies, thyroid etc.)
ix ?sjogrens
- bloods- anaemia, ESR, **raised igG
- **- RF (100%)!!!!!!!!!
- **- anti-ro, anti-la (70%)
- ANA
- **- schirmer’s test- filter paper 5 min on eye– <10mm travel
- salivary gland biopsy- lymphocytes
tx sjogrens
- oral hygeine
- artificial tears, saliva, lube
- muscarinic agonist (pilocarpine)- increase saliva prod via parasymp stim.
- steroids, DMARDS
- hydroxychloroquine
what is polymyositis/dermatomyositis
- symmetrical inflammation of skin and striated muscle
- can present as a paraneoplastic syndrome as underlying cancers in breast, lung, ovarian, gastric
sx polymyositis/dermatomyositis
dermato: - rash, Gottrons papules- red papules over knuckles
- muscle pain- proximal, symmetrical, shoulder, pelvis– onset over weeks
- muscle weakness
- fever, arthralgia
* *- raynauds
* *- fibrosis, arrhythmias
* *- other AI conditions
ix polymyositis/dermatomyositis
- CK >1000
- ANA, Anti-SRP
- *- EMG - abnormal muscle activity
- raised WBC, ESR
- definitive – skin/muscle biopsy
**- screen for malignancy- CXR, TFTs, CT
management of polymyositis/dermatomyositis
- PT/OT
- high dose steroids, OD/top
- methotrexate
- azathioprine
- IV ig
- infliximab, etanercept (biologics)
Name large vessel vasulitises
- Takyasu
- Giant cell/temporal
Name small vessel vasulitises
- microscopic polyangitis
- granulomatosis with polyangitis (wegner’s)
- eosinophilic granulomatosis with polyangitis (churg-strauss)
- buerger’s/thomboangiitis obliterans
- polyarteritis nodosa
general presentation of vasculitis
- systemically unwell, fever
- *- arthralgia/arthritis
- wt loss, anorexia
- infarction (stroke, bowel, peripheral vasc, ulcers, gangrene)
- HTN, renal failure via glomerluonephritis
- *- scleritis, sight loss
- *- psychosis, chorea, seizures, impaired cognition
- angina
ix for ?vasculitis
- ANCA- small/medium
- cANCA
- pANCA
- vessel biopsy
- dopplers
- CT/MRI for larger vessels
tx for vasculitis (generally)
- smoking cessation
- steroids (cortico- pred)
- methotrexate
sx giant cel arteritis
- headache, scalp tenderness
- impalpable temporal arteries– distended with reduced pulsation
- jaw/tongue cramp
- ischaemic optic neuro- sudden painless monocular and severe visual loss- irreversible- amaurosis fugax
- may be preceded by transient loss- emergency, reversible
- malaise, fatigue, wt loss
what conditions is giant cell arteritis assoc with?
- polymyalgia rheumatica (pain, stiffness in shoulder /neck/hip girdle muscles over days)
ix of ?giant cell arteritis
- bloods- ESR/CRP, FBC, UE
- temporal artery USS (thickening)
- temporal artery biopsy- skip lesions, mulitnucleated cells
diagnostic criteria fro giant cell arteritis
3 or more of
- > 50yo
- new headache
- tmeporal artery tenderness/decreased pulsation
- ESR >50
- abnormal temptoral artery biopsy
tx giant cell
- pred 80mg PO OD
- azathioprine, metho, biologics
- Ca/vit D/bisphos/DEXA
- use falling ESR as guidance
sx of behcet’s disease
- oral ulcer
- genital ulcer
- *- ant. uveitis
- *- arthritis
- systems sx- GI, cardiac, resp, neuro
- systemic sx
ix for ?behcet’s
- Pathergy- skinprick– swollen >5mm in 48hours
- XR, FBC, UE, ESR
- HLA B51
tx behcet’s
- betamethasone oral
- lidocaine genital
- colchicine and steroids PO
what is polymyalgia rhuematica
- inflam of shoulder, neck and pelvic girdle
sx of polymyalgia rhuematica
- stiffness, worse at rest
- shoulder, neck, pelvic, arm (BL) pain
- fever, fatigue, anorexia, wt loss
- carpal tunnel, arthritis, oedema
- +- GCA sx
ix for ?polymyalgia rheumatica
- ESR/CRP raised
- CK (rhabdo/polymyositis), ALP, EMG, TFT, MSU (bence jones), ANA/anti-ccp, – all normal
- response to steroids is often used to diagnose