MS and other demyelinating disease Flashcards
destruction of the myelin sheaths of the nerve fibers with relatively sparing of the other elements of nervous tissue
demyelinating disease of CNS
infiltration of inflammatory cells, particularly in a perivenous distribution
demyelinating disease of CNS
lesions of demyelinating disease of CNS are primarily in the GRAY MATTER. True or False?
False
esions of demyelinating disease of CNS are primarily in the WHITE MATTER
the most common and important inflammatory demyelinating disease
Multiple Sclerosis (MS)
MS is a chronic condition, typically characterized by episodes (attacks) of focal disorders of what 3 structures?
MS is a chronic condition, typically characterized by episodes (attacks) of focal disorders of:
Optic nerve
Brain
Spinal Cord
Lesions of MS are disseminated in ______ and ______.
Lesions of MS are disseminated in TIME and LOCATION
means that there should be at least 2 attacks
Dissemination in TIME
means that there should be at least 2 lesions different locations or areas in the nervous system involved
Dissemination in LOCATION
Which procedure has the capacity to identify clinically inevident lesions and lesions of different ages.
MRI
This procedure helps to demonstrate lesions disseminated in time and location
MRI
“Disease of young people”
Multiple Sclerosis
Age onset: 20-40 years old
Very rare: <10 years old and >60 years old
Incidence of MS is 2-3x more common in females than in males. True or false?
TRUE
MS is 2-3x more common in FEMALES than in males
Increasing or Decreasing?
Prevalence of MS increases with ______ distance from the Equator.
INCREASES
Prevalence of MS increases with INCREASING distance from the Equator with exemptions)
High risk: 40-45 to 60 degrees North and South
Japan shares the same latitude as the Northern America. It has the same high incidence in MS. True or False?
FALSE
Japan shares the same latitude as the Northern America. However, it has a LOW incidence in MS
Cause of MS
Unknown
Postulated combination of Genetic Susceptibility and Environment, w/ Initial trigger (usually viral infections)–> leads to autoimmune mechanism–> Demyelination
On sagittal view of the MRI-T2 Flair images, plaques of MS seem to form _______ projections from the corpus callosum.
FILIFORM/ FINGER-LIKE PROJECTIONS
On sagittal view of the MRI-T2 Flair images, plaques of MS seem to form FILIFORM/ FINGER-LIKE PROJECTIONS from the corpus callosum. Hence, described as DAWSON’S FINGER
