MRONJ Flashcards
1
Q
What are bisphosphonates used for
A
prevent osteoporosis, treat hypercalcaemia, reduce pain from cancer that has spread to bone, tx for cancers that cause bone damage
2
Q
Why are bisphosphonates used for cancer tx
A
cancer cells release cytokines and growth factors which stimulate osteoclasts, this increases
pain
blood Ca levels
fracture risk
3
Q
How do bisphosphonates work
A
target areas of high bone turnover
absorbed by osteoclasts and inhibit therefore preventing breakdown
4
Q
What guidance for MRONJ
A
SDCEP
5
Q
High risk for MRONJ if
A
Prev MRONJ
anti resorptive or anti-angiogenic tx for cancer
