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Malignant Hematology > MPN > Flashcards

MPN Flashcards

1
Q

What are high risk comutations in MF?

A

EZH2
SRSF2
ASXL1
IDH1/2

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2
Q

What driver mutations occur in MF?

A

CALR (favorable)
MPL
JAK2 (unfavorable)
Triple negative (poor)

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3
Q

Rate of progression for
-CCUS
-ICUS
-CHIP

A

~10
<5
<1

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4
Q

Treatment for low risk MF

A

Anemia - EPO
Splenomegaly - Ruxilitinib
Proliferative - HU
IFN - I’m pregnancy

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5
Q

Treatment for high risk MF - transplant ineligible

A
  • ruxolitinib
  • pacritinib
  • fedratinib
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Malignant Hematology (3 decks)

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