Lymphoid

Question 1

BCR-ABL transcripts

Answer 1

190 - ALL
210 - CML

Question 2

Ph-like mutations (5)

Answer 2

JAK-STAT - CRLF / EPOR
ABL pathway - ABL, FGFR, PDGFR

Question 3

Mutation that confers TKI resistance in ALL

Answer 3

T315I

Question 4

High risk disease for ALL (4)

Answer 4

• MRD end of induction
• MLL (4:11) KMT2A
• IFKZ1
• gain of 21

Question 5

Relapsed refractory ALL Tx (5)

Answer 5

Young <25 - CART
Older - get to CR and then ALLO
- blina
- ponatinib
- Asciminib
- salvage chemo

Question 6

Implication of EZH2mut FL

Answer 6

Possible response to tazemetostat

Question 7

Treatment for Ph + ALL

Answer 7

• consider FOA TKI/ pred (if not going to allo)
• or CALGB 10403, HYPERCVAD, Larson

Question 8

Translocation genes on chromosome
2
8
11
14
18
22

Answer 8

2 - kappa
8 - myc
11 bcl1 (cycling d1)
14 - igH
18 - bcl2
22 - lambda

Question 9

DLBCL Tx

Answer 9

Stage I / II contiguous - RCHOP x3 +ISRT or RCHOPx4
Stage II+ BULKY - RCHOPx6

Question 10

IPET timing for DLBCL

Answer 10

After cycle 3

Question 11

NCCN recs doe 2L R/R DLBCL

Answer 11

<12m - CART
>12m - salvage chemo

Question 12

MCL fit and unfit regimens

Answer 12

Fit - RDHAP/R-maxiCHOP
- HYPERCVAD
-RB-RC

Unfit - R Benda

Question 13

Buekitts regimens

Answer 13

• R CODOX M IVAC
• hyper CVAD
• DA EPOCH R

Question 14

Polymorphic PTLD Tx

Answer 14

• single site - RT / surgery
• multiple sites - R or RCHOP

Question 15

Treatment for nMZL

Answer 15

I/II - ISRT
IV - Observation, BR, BTKi

Question 16

Treatment for enMZL

Answer 16

Gastric I/II
- hpylori without t11:18 - quad
- hpylori with t11:18 - quad and ISRT
- no hpylori - ISRT
IV - observation, BR BTKi

Question 17

Hairy cell IPT and difference with vHCL

Answer 17

11c/19/20/23/25/103

VHCL without 25

Question 18

Third line tx for HCL

Answer 18

• muxetumomab
• BRAF

Question 19

Castlemans dx (3)

Answer 19

1 - fever
2 - CRP >20
3 MOF

Question 20

Castlemans tx

Answer 20

HHV8 negative - siltuximab
HHV8 positive - rituximab

Question 21

R/R HL Tx

Answer 21

ICE - Auto - BV x1 year

Question 22

What virus is associated with primary effusion lymphoma (PEL)

Answer 22

HHV8

Question 23

PTCL Tx

Answer 23

Transplant eligibility
- CHOEP
-BV CHP

ineligible
CHOP