Movement disorders - Parkinson's , TICS and chorea , tremor

Question 1

what can you do to test for Parkinsons

Answer 1

do a trial of L-dopa and carvidopa

Question 2

dopamine agonists - amorphine other examples

Answer 2

roigotine ( patch ) ,ropinorol D2 , pramipexol ( D2and3)

Question 3

with l-dopa trial does therapeutic window get smaller as the disease progresses

Answer 3

yes

wearing off phase

Question 4

if an electrode is used to treat parkinons where is it put?

Answer 4

sub-thalamic nucleus

Question 5

drug induced parkinosns caused by what

Answer 5

anti-emetics such as cyclising and metoclopramide

anti-psychotics such as haloperidol - causes dopamine depletion

Question 6

the four Parkinson’s plus syndromes

Answer 6

progressive super nuclear palsy PSP - hummingbird midbrain
pons is unaffected

MSA - multiple stum atrophy - celrebllar degeneration

Question 7

the four Parkinson’s plus syndromes

Answer 7

progressive super nuclear palsy PSP - hummingbird midbrain
pons is unaffected

MSA - multiple stum atrophy - celrebllar degeneration, spastic paraparesis and sleep apnoea - treatment is DDav/ISC and elastic stockings hd head up tilt and fludrocrotisone

Wilsons disease and CBD

Question 8

dyskinesia

Answer 8

too much movement - Ldopa can cause this

Question 9

what can you use to treat too much movement

Answer 9

toplaramate - anti convulsant

propanolol

Question 10

treat bipolar

Answer 10

sodium valproate and lithium

Question 11

Orthostatic tremor is a condition that involves the unintentional rhythmic muscle movement of one or more parts of the body. It usually occurs when a person is standing upright. It is seen as progressive condition.

Answer 11

benzodiazepine drugs such as clonazepam (Klonopin) to treat people for whom tension or anxiety worsens tremors. Side effects can include fatigue or mild sedation.

Question 12

The ABCs of pharmacotherapy for dystonia ( isorder characterized by involuntary muscle contractions that cause slow repetitive movements or abnormal postures)

Answer 12

Artane - anticholinergics - his helps decrease muscle stiffness, sweating, and the production of saliva, and helps improve walking ability in people with Parkinson’s disease.
Baclofen
Clonazepam

Question 13

tourettes

Tourette Syndrome (TS) is a condition of the nervous system. TS causes people to have “tics”. Tics are sudden twitches, movements, or sounds that people do repeatedly. People who have tics cannot stop their body from doing these things

Answer 13

Neuroleptics. Neuroleptics, also called antipsychotics, are the main medicines for tics. They work by altering the effects of the chemicals in the brain that help control body movements. Examples include risperidone, pimozide and aripiprazole.

Question 14

Huntington’s cause

Answer 14

CAG tri-nucelotide repeat disease chromosome 4