Movement disorders (Link to Parkinsons)

Question 1

Motor neurone disease

Answer 1

Neurodegenerative condition which affects brain & spinal cord.

Degeneration of motor neurone which leads to muscle weakness/cramps, wasting/stiffness, loss of movement

REFER ALL

No cure - do non pharmacological stuff
- Nutrition, Psychosocial support, physio, exercise programmes, use of mobility aids

Drugs
Muscular symptoms - Quinine for cramps
2nd line Baclofen. ALT gabapentin, tizanidine, dantrolene
Muscle stiffness - As above except Quinine
Saliva - Antimuscarinics, Glycopyrronium ALT BOTOX
Thick saliva - Humidifiers/Nebulisers or carbocisteine.
Respiratory symptoms - Breathlessness use Opioids/Benzos if worsens with anxiety

Riluzole - extends life