Movement Disorders: Clinical Phenomenology (2nd hour) Flashcards

1
Q

What are chorea?

A

Irregular, rapid, random movements that seem to flow from one body part to another.

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2
Q

What is ballism?

A

A form of chorea with large amplitude, flinging motions. Often of proximal muscles. (recall the woman who was lurching forward with her shoulder)

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3
Q

What is athetosis?

A

Writhing motion, often slower and distal.

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4
Q

What is dystonia?

A

Sustained contraction -> twisting / abnormal postures

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5
Q

What is tremor?

A

rhythmic, oscillatory movements

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6
Q

What are tics?

A

Intermitted, repeated, semi-voluntary movements. (can often be repressed)

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7
Q

What is myoclonus?

A

Shock-like, rapid contraction/jerk

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8
Q

Review-ish: Where is essential tremor localized?

A

the cerebellum (or -ish)

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9
Q

How is a tremor in ET different from a tremor in PD (Parkinson’s)?

A

PD: rest tremor more pronounced
ET: tremor comes out when trying to move

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10
Q

How will writing be different in PD vs. ET?

A

PD: micrographia (small handwriting)
ET: large, jagged, messy handwriting

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11
Q

Is PD more often symmetrical or asymmetrical?

A

More often asymmetrical.

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12
Q

In which disease (that we’ve focused on) will you be mostly likely to see chorea?

A

Huntington’s

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13
Q

Name 4 non-PD Parkinsonisms.

A

Multiple systems atrophy, Progressive supranuclear palsy, corticobasal degeneration, Wilson’s disease

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14
Q

Key feature of Multiple systems atrophy?

A

Autonomic failure, often manifesting as bad orthostatic hypotension

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15
Q

Key features of progressive supranuclear palsy?

A

opthalmoparesis, “surprised” expression

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16
Q

Key features of corticobasal degeneration?

A

apraxia (can’t initiate voluntary movements), dystonia

17
Q

Key feature of Wilson’s disease?

A

young onset, dystonia

18
Q

Complications of levodopa therapy?

A

peak-dose chorea (when it’s too high), visual hallucinations, etc.

19
Q

What does deep brain stimulation (DBS) for Parkinson’s block? Why does that work?

A

Blocks the subthalamic nucleus (STN) and globus pallidus interna (GPi) output.
Recall GPe –| STN -> SNr/GPi –| motor activity…
Less STN and GPi, more motor activity.