Movement Disorders Flashcards
1
Q
Basal ganglia
A
- Cortex excites caudate/putamen
- Caudate/putamen inhibits GPi/SNr
- GPi/SNr inhibits thalamus
- Caudate/putamen inhibit GPe
- GPe inhibits STN
- STN excites GPi/SNr
2
Q
Direct pathway
A
-Cortex to caudate/putamen to GPi/SNr to thalamus to cortex
3
Q
Indirect pathway
A
-Cortex to caudate/putamen to GPe to STN to GPi/SRr to thalamus to cortex
4
Q
Basal ganglia neurotransmitters
A
- GABA: inhibitory
- Glutamate: excitatory
- D1: excites direct
- D2: inhibits indirect
5
Q
Parkinson’s genetics
A
- PARK1 gene, alpha-synuclein, AD
- PARK2 gene, parkin, AR
- LRRK2 gene, leucine-rich repeat kinase, AD
6
Q
Entacapone
A
COMT inhibitor
7
Q
Carbidopa
A
Peripheral dopa-decarboxylase inhibitor
8
Q
Ropinirole/pramipexole
A
D2 and D3 agonists
9
Q
Rasagiline/selegiline
A
MAO-B inhibitors
10
Q
Trihexyphenidyl
A
Anticholinergic
11
Q
Amantadine
A
- Anti-glutamatergic
- increases pre-synaptic dopamine release
- dopamine reuptake inhibitor
12
Q
Episodic ataxias
A
- I: facial twitching, w/ myokymia/myotonia
- II: nystagmus
- III: tinnitus, vertigo
- IV:ocular motion abnl
