AEDs

Question 1

Topiramate

Answer 1

Trade name: Topamax
Mechanism: VG Na channel inhibition, GABAa agonism, NMDA-glutamate antagonism
Seizure type: partial, GTC, absence
Side effects: weight loss, drowsiness, word-finding difficulties, cognitive impairment, kidney stones, angle-closure glaucoma

Question 2

Gabapentin

Answer 2

Trade name: Neurontin
Mechanism: L-type VG Ca channel
Seizure type: Adjunct for partial seizures
Side effects: Fatigue, HA, ataxia

Question 3

Hepatic enzyme inducers

Answer 3

Phenytoin
Carbamazepine
Phenobarbital
Primidone
Topiramate(>200mg/day)
Oxcarbazepine

Question 4

Hepatic enzyme inhibitors

Answer 4

Valproic acid

Question 5

Ethosuximide

Answer 5

Trade name:
Mechanism: T-type Ca channel inhibitor
Seizure type: Absence
Side effects:

Question 6

Phenytoin

Answer 6

Trade name: Dilantin
Mechanism: VG Na channel
Seizure type: Partial and GTC
Side effects: Hepatic failure, gingival hyperplasia, coarse facial features, nystagmus, ataxia, osteoporosis

Question 7

Valproic acid

Answer 7

Trade name: Depakote
Mechanism: Na, T-type Ca channel inhibition and GABAa agonist
Seizure type: Everything
Side effects; Weight gain, PCOS, pancreatitis, thrombocytopenia

Question 8

Carbamazepine

Answer 8

Trade name: Tegretol
Mechanism: Na channel inhibition
Seizure type: Partial
Side effects: Nystagmus, hyponatremia, dizziness, autoinduction

Question 9

Oxacarbazepine

Answer 9

Trade name: Trileptal
Mechanism: Na channel inhibition
Seizure type: Partial
Side effects: Hyponatremia

Question 10

Lacosamide

Answer 10

Trade name Vimpat
Mechanism: Enhancement of slow inactivation of VG Na channel, binds CRMP2
Seizure type: Adjunct for partial
Side effects:

Question 11

Rufinamide

Answer 11

Trade name: Banzel
Mechanism: Prolongs inactive state of Na channels
Seizure type: LGS
Side effects: