Movement Disorders Flashcards
In general, what 4 classifications do we look at when a patient presents with a tremor?
Rest vs. Action Body Part Affected Frequency Amplitude (fine/course)
How do we tell if a patient has a resting tremor?
Support the body part against gravity
What can increase or decrease a resting tremor?
Movement
If a patient goes to grab something and the shake, what’s it called?
Intention tremor
If a patient presents with a tremor that is high-frequency, and low amplitude (fine & fast), what diagnosis?
Physiologic tremor
When does someone typically have a physiologic tremor?
Hyper-adrenergic states (anxiety, caffeine, or withdrawals of caffeine or alcohol)
If a 65 year old patient presents with a tremor that is in the right arm and has slowly gotten worse over the past couple months, and their neurological exam is normal, what ddx?
Benign essential tremor
What are the main things we think of for a benign essential tremor?
60+, UE tremor, starts on one side and move to bilateral, SLOW progression
How do we treat a benign essential tremor?
Beta blockers, rest/sleep, eat well
A patient presents with a tremor involving the left hand and the first two fingers that’s been there for the past year or so. They have noticed a decrease in their affect, on PE they have no weakness and no changes in DTR’s but they do have cogwheel, what ddx?
Parkinson’s
What is decreased in Parkinson’s disease?
Dopamine in the substantia nigra
What are the 4 cardinal signs of Parkinson’s disease?
Tremor, rigidity, bradykinesia, and postural impairment
What is Bradykinesia?
Slowness of movements (gait and speech)
What’s the classic name for a Parkinson’s gait? How do they turn?
Festinating gait with Turn “en bloc” (along with freezing)
Although there’s no definitive diagnosis for Parkinson’s what can we look at?
Dopamine levels – high suspicion. Refer
What symptoms are NOT Parkinson’s?
No response to levodopa, symmetrical, rapid progression, abnormal eye movements (that’s MS)
At what point do we treat Parkinson’s?
When functional disabilities begins
How can we treat Parkinson’s?
Levodopa (so dopamine can cross the BBB) but it wears off :(
What are some S/E of levodopa?
Increase in uncontrolled movement (Dyskinesias)
When Levodopa begins to wear off, what can you add?
Entacapone
Dopamine Agonists: Ropinirole
Anticholinergics: Benztropine (Cogentin)
MAO-B inhibitor: Selegiline