Movement Disorders

Question 1

Rate-limiting step in DA production?

Answer 1

Tyrosine Hydroxylase

Question 2

Converts L-dopa to DA?

Answer 2

Dopa decarboxylase

Question 3

Sinemet = ?

Answer 3

C + L Dopa

Question 4

Bromocriptine?

Answer 4

DA agonist

Question 5

Pergolide?

Answer 5

DA agonist

Question 6

Pramipexole?

Answer 6

DA agonist

Question 7

Ropinirole?

Answer 7

DA agonist

Question 8

Amantadine MOA?

Answer 8

Stimulates DA neurons to release DA

Question 9

Tolcapone/Entacapone MOA?

Answer 9

COMT inhibitors

Question 10

Benzotropine use and MOA?

Answer 10

Anti-cholinergic for Parkinsons

Question 11

Action Tremor localization?

Answer 11

Cerebellum

Question 12

What can resolve essesential tremor?

Pharm vs non-pharm?

Answer 12

Alcohol

B-blocker
Klonopin

Question 13

Other action tremor causes?

Answer 13

Lithium
Valproate
Amiodarone
B-agonist
Caffiene
Alcohol withdrawal

Question 14

MRI purpose in Parkinsons?

Answer 14

Rule out treatable cause

Question 15

Tx. for Parkinsonss Drug induced dyskinesia?

Answer 15

Amantadine

Question 16

Multiple Systems atrophy symptoms?

Answer 16

PD
Ataxia
CS
Autonomics

Question 17

MSA cause?

Answer 17

a-synuclein defect

Question 18

Parkinsons vs. LBD vs. MSA?

Answer 18

PD = Striatum
LBD = Striatum and cortex
MSA = Striatum, autonomics, cerebellum

Question 19

Athetosis?

Answer 19

Slow distal writhing

Question 20

Primary Distonia in Ashkenazi Jews?

Answer 20

Age

Question 21

Primary distonia in pt

Answer 21

Dopa responsive dystonia

Question 22

Symptomatic TX for dystonia?

Answer 22

Baclofen, anti-ACh, botox

Question 23

Tx for Tourettes?

Answer 23

A2 agonist (Clonidine)
Anti-psych (Risperidone)

Question 24

Tremor disappears during sleep indicates?

Answer 24

Basal Ganglia origin
PD
HD
Wilsons

Question 25

Work-up for tremor?

Answer 25

Hx of trauma?
Other signs? -- stroke
TSH
Ceruloplasmin
Heavy metals