Movement Disorders

Question 1

Huntington’s Disease

Answer 1

Pathophysiology causes brain cells to waste away.
Decrease of GABA and GABA receptors in the basal ganglia
Characterized by:
Chronic progressive chorea
Psychological changes
Dementia

Question 2

Suppress chorea Treatment Meds

Answer 2

Tetrabenazine (VAMT Inhibitor)

Neuroleptics (antipsychotics)…Deplete cerebral dopamine

Question 3

Antidepressants:

Answer 3

Fluoxetine (Prozac)
Sertraline (Zoloft)
Nortriptyline (Aventyl, Pamelor)

Question 4

Antipsychotic

Answer 4

Resperidone (Resperdal)

Olanzapine (Zyprexa)

Question 5

Anticonvulsants

Answer 5

Clonazepam (Klonopin)
Valproic Acid (Depakote)

Question 6

Essential Tremor Treatment

Answer 6

Propranolol (Inderol) – Beta Blocker
Atenolol (Tenormin) – Beta Blocker of choice for those with asthma or bronchospasm
Mysoline (Primidone) – Anticonvulsant
Gabapentin (Neurontin) - Anticonvulsant

Question 7

Parkinson’s Disease TRAP

Answer 7

progressive neurodegenerative disorder characterized by:
Resting and postural Tremor – T
Rigidity – R
Akinesia (Bradykinesia) – A
Postural instability – P

Question 8

Parkinson’s Disease Pathophys

Answer 8

Marked loss of dopaminergic nerve terminals in the substantia nigra
Relative increase in cholinergic interneuron activity occurs due to degeneration of dopamine pathways, which contributes especially to tremor.