Movement Disorder Drugs Flashcards
Levodopa
MOA, Adverse Effects (6) Drug interaction, Contraindications (4)
Dopamine agonist
Anorexia N/V Postural Hypotension Choreoathetosis Behavior changes Akinesia
Non-selective MAOI’s (HTN Crisis)
Acute angle glaucoma
Melanoma
GI Ulcer
Psychosis
Carbidopa
MOA, Uses (4)
DOPA decarboxylase inhibitor
Decrease Levodopa adverse effects
Decrease Levodopa dosing requirements
Increase Levodopa half-life and plasma concentration
On-Off Phenomenon
On (2) and Off (2) Descriptions
On periods occur for a couple hours after drug dosing followed by off when drugs wear off
On Periods
Improved mobility
Marked dyskinesia (voluntary movement issues)
Off Periods
Akinesia
Rigidity
Apomorphine
MOA, Indication, Formulation, Adverse Effects (5)
D2 receptor agonist
On-Off Phenomenon treatment
Subcutaneous injection
Nausea (treat with trimethobenzamide) Dyskinesia Drowsiness Sweating Hypotension
Bromocriptine
MOA, Drug Classification
D2 receptor agonist
Ergot alkaloid
Pramipexole
MOA, Indications (2), Metabolism
D3 receptor agonist
Parkinson’s
Restless Leg Syndrome
Mostly excreted unchanged by kidneys
Ropinirole
MOA, Indications (2), Metabolism
D2 receptor agonist
Parkinson’s
Restless Leg Syndrome
CYP450 metabolized
Dopamine Receptor Agonist Drugs
Examples (3) Adverse Effects (6) Contraindications (4)
Bromocriptine
Pramipexole
Ropinirole
Digital vasospasm Edema (discontinue if present) Constipation Reflux esophagitis Confusion Hallucinations
Peripheral vascular disease
Recent MI
Peptic ulcers
Psychosis
Monoamine Oxidases
Chemicals Metabolized
MAO-A (2) MAO-B (2) Both A/B (2)
MAO-A:
NE
5-HT
MAO-B
Phenylethylamine
Benzylamine
MAO-A and MAO-B:
DA
Tryptamine
Selegiline
MOA, Indications (3) Contraindications (3) Similar Drugs (2)
MAO-B selective
Slow DA breakdown for Parkinson’s
Prolong Levodopa Effects
On-Off Phenomenon
SSRI’s
TCA’s
Meperidine
(cause Serotonin syndrome)
Rasagiline
Safinamide
Catechol-O-Methyltransferase Inhibitors
Examples (2) with Areas of Action (2/1)
MOA, Indication, Adverse Effects (4)
Tolcapone (Central and Peripheral)
Entacapone (Peripheral)
Block COMT metabolism of Levodopa
Parkinson’s with Levodopa response fluctuations
Orange urine
Diarrhea
Abdominal pain
Sleep issues
Amantadine
Drug Classification, Adverse Reaction
Antiviral, MOA unknown
Levido Reticularis: Purple leg discoloration
Parkinson’s Anticholinergics
Examples (5) MOA, Effects (2) Adverse Effects (5)
Benztropine Biperiden Trihexyphenidyl Orphenadrine Procyclidine
Muscarinic antagonists
Treat Tremor and Rigidity of Parkinson’s
Sedation Confusion Constipation Urinary retention Blurry vision
Parkinsonian Tremor
Treatments with MOA (6)
Metoprolol: Beta-1 blocker
Propranolol: Beta-1 blocker
Primidone: anti-epileptic
Topirimate: 5-HT agonist
Alprazolam: benzo
Botulinum Toxin A
Restless Leg Syndrome Treatments (5)
Levodopa Pramipexole Ropinirole Diazepam Clonazepam
