Mouth, throat, head and neck Flashcards
aphthous stomatitis
- aka cancer sore
- most common acute oral lesion
- often recurrent
classification of aphthous stomatitis
- simple- 1 to several episodes lasting 14 days in oral mucosa
- complex-oral and genital lesions, more numerous and last 4-6 weeks
risk factors for aphthous stomatitis
- smoking
- genetics
- trauma
- hormones
- stress
- food/ drug hypersensitivity
- immunodeficiency or other GI disorders
- vit b12, folic acid, or Fe deficiency
clinical presentation of aphthous stomatitis
- round, oval, clearly defined ulcers
- erythematous rim with yellow center
- usually small
- painful
management of aphthous stomatitis
- oral hygiene
- no alcohol mouthwash, soft tooth brush
- pain control- viscous lidocaine
- swish and spit steroids
- for complex cases can have intralesional steroids, colchisine, dapsone, immunomodulators
oral leukoplakia
- benign
- white gray lesions that cant be scraped off
- clinical significance depends on degree/presence of dysplasia
- associated with HPV
- common in smokeless tobacco users and pure inflammatory conditions
clinical manifestations of oral leukoplakia
- white gray lesions
- in trauma prone regions
- thin areas show more dysplasia
- not painful
- flat and not well defined
diagnosis of oral leukoplakia
- history and PE
- if indurated should be biopsied
management of oral leukoplakia
- doesnt require tx
- can surgically remove
- cryoprobe
- chemoprevention
- oral retinoids
Herpes
- more common in women
- usually transmitted by people who dont know they have it
- recurrent infection common
Herpes primary infection
- highly variable
- usually severe with systemic sx
- Fever, LAD, drooling, decreased PO intake
Herpes recurrent infections
- usually less severe
- more localized
clinical manifestations of herpes
- affects gingiva
- multiple oral vesicular lesions on erythematous base
- herpetic gingivastomatitis most common
- prodrome of burning, tingling, pain
management of herpes
- systemic antivirals
- swish and spit miracle mouthwash
- supportive
- popsicles
oral candida
- aka thrush
- involves mucous membranes- oropharyngeal and esophageal
what is the most common cause of oral candida
- candida albicans
what are the types of oral candida
- pseudomembranous- most common, forms white plaques
- atrophic- aka denture stomatitis, erythema without plaques
epidemiology of oral candida
- young infants
- older adults who wear dentures
- abx or chemo
- radiation to head and neck
- immunodeficiency
- inhaled steroids
- xerostomia
clinical manifestations of oral candida
- dry mouth, loss of taste
- white plaques
- erythema without plaques if denture wearer
- pain with swallowing or eating if esophageal
- beefy red tongue with dentures
- painful fissuring on sides of mouth
diagnosis of oral candida
- clinical
- white plaques removable
- KOH
- if refractory test for HIV
management of oral candida in health patients
- local therapy
- nystatin swish and swallow
- clomitrazole troches
- miconazole buccal tabs
- PO diflucan
what type of cancer is mainly found in the head and neck?
- squamous cell carcinomas
- arise from mucosal surfaces
- generally have good prognosis if detected early
what type of head and neck cancers respond best to treatment
- HPV associated cancer
- HPV cancers usually seen in younger patients
categories of oropharynx cancer
- carcinoma of oral cavity proper
- carcinoma of oropharynx
- carcinoma of lip vermillion
risk factors for oropharyngeal cancers
- smoking**
- alcohol abuse **
- HPV infection**
- EBV
- diet
- immune status
- environmental/ occupational pollutants
- genetics
anterior oral cavity cancers
- SCC
- ulcerative
- painful later in disease
- may be mass with raised, rolled boarder
- tongue is common site
- often see lesions on floor of mouth as well
what is the biggest risk factor for anterior oral cancers
- alcohol abuse
- tobacco abuse
posterior oral cancers
- SCC
- mostly associated with erythema rather than lesions
- pt presents with neck mass, sore throat, dysphagia
what is the biggest risk factor for posterior oropharyngeal cancers
- HPV (16 and 18)
clinical presentation of oropharyngeal cancers
- leukoplakia or erythroplakia*
- speckled erythroplakia
- dentures that no longer fit properly*
- most DONT have hx of premalignant lesions
- pain
- possible airway obstruction
- loosening of teeth
- LAD
what is the best imaging to dx oropharyngeal cancers?
- CT
- need chest CT if there is distant metastasis
- f/u with MRI or PET scan
treatment and prognosis of localized oropharyngeal cancers
- curative intent
- surgery for smaller lesions
- radiation preferred in laryngeal lesions
- survival is good
- if recurrence usually happens if first two years
treatment and prognosis of advanced oropharyngeal cancers
- curative intent
- combo of surgery, radiation, and chemo
- can do chemo and radiation at the same time
treatment and prognosis of recurrent/ metastatic oropharyngeal cancers
- usually palliative intent
- poor prognosis
- poor response to chemo
what is the most common cause of viral tonsillitis/ pharyngitis
- rhinovirus
clinical manifestations of viral tonsillitis/ pharyngitis
- sore throat
- coryza*
- cough*
- N/V/ abdominal pain
- malaise/ fever/ hoarseness
- more erythematous