MOUTH AND OESOPHAGUS Flashcards

1
Q

How many salivary glands are there and what are they called?

A
  • Parotid gland
  • Submandibular gland
  • Sublingual gland
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2
Q

What action does the tongue do?

A

Pushes bolus of food to back of the mouth and also has sensory receptors to detect food

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3
Q

What is mastication and it’s importance?

A
  • Mastication is chewing food and breaking it down to increase it’s SA:V ratio
  • The purpose of this is so that there is more area for enzymes to work on and for absorption to take place
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4
Q

What does saliva do to the bolus of food?

A

Saliva lubricates food before swallowing

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5
Q

What type of cells are found in the salivary glands and what do they produce?

A
  • Acinar cells - produce proteins and enzymes
  • Ductal cells - secrete water and electrolytes
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6
Q

What is the volume of saliva that is produced by the salivary glands in 24 hrs

A

1.5 L

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7
Q

What type of saliva does each gland produce?

A
  • Parotid - water
  • Submandibular - viscous
  • Sublingual - viscous
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8
Q

Which type of cells produce mucous ?

A

Goblet cells

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9
Q

What 3 substances does saliva produce for its immune function?

A
  • IgA - IgA antibodies bind to pathogenic antigens
  • Lactoferrin - binds iron and is bactericidal
  • Lysozyme - attacks bacterial cell wall = cell lysis
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10
Q

How is the secretion of acinar cells modified?

A

Modified by salivary duct cells which makes saliva hypotonic and alkaline

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11
Q

Why is it important that saliva is alkaline?

A
  • It protects the teeth from bacterial acid
  • Neutralises gastric acid that refluxes into the oesophagus
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12
Q

What is sjorgren’s syndrome

A

An autoimmune attack of salivary and tear glands which results in dry mouth and eyes. It is associated with rheumatoid arthritis and commonly affects women

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13
Q

What is another name for mumps?

A
  • Parotitis
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14
Q

What is the parasympathetic innervation of the submandibular gland and what does stimulation lead to?

A
  • Facial nerve CN VII
  • Stimulation results in secretion
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15
Q

What is the parasympathetic innervation of the sublingual gland and what does stimulation lead to?

A
  • Facial nerve - CN VII
  • Stimulation results in secretion
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16
Q

What is the parasympathetic innervation of the parotid gland and what does stimulation lead to?

A
  • Glossopharyngeal nerve CNXI
  • Stimulation results in secretion
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17
Q

What is the sympathetic innervation of the salivary gland and what does stimulation lead to?

A
  • Thoracic sympathetics in the superior cervical ganglion
  • Stimulation results in vasoconstriction and thick mucous secretion
18
Q

What are the 4 phases to swallowing?

A
  • Oral preparatory phase
  • Oral phase
  • Pharyngeal phase
  • Oesophageal phase
19
Q

What happens in oral preparatory phase?

A

Food is masticated (chewed) to reduce it to a consistency that can be swallowed

20
Q

What happens in the oral phase?

A

The tongue properly food posteriorly until the pharyngeal swallow is triggered

21
Q

When does the pharyngeal swallow occur?

A

When food gets to the back of the mouth in the oral phase

22
Q

What happens in the pharyngeal phase?

A

Once the pharyngeal swallow is triggered, the bolus is transported through the pharynx

23
Q

What 3 things occur in the pharyngeal phase so that the bolus can be transported through the pharynx?

A
  • Closure of the glottis via the the movement of the epiglottis
  • Cessation of breathing
  • Relaxation of the upper oesophageal sphincter
24
Q

What happens in the oesophageal phase

A

The bolus moves via oesophageal peristalsis from the upper oesophageal sphincter through the oesophagus to the lower oesophageal sphincter

25
Where does the oesophagus start and end?
Starts in the thorax and ends in the oesophageal hiatus which is the hole in the diagram.
26
What type of muscle is found in the upper third of the oesophagus, middle third and lower third?
- Upper = striated muscle - Middle = striated and smooth - Lower = smooth muscle
27
What is GORD?
Chronic symptoms or mucosal damage produced by the abdominal reflux in the oesophagus. Acid reflux occurs multiple times a day every day
28
What are 3 causes of GORD?
-
29
What are 3 causes of GORD?
- Obesity - this impacts intra abdominal pressure - Hiatus hernia - Zollinger Ellison syndrome
30
What are 4 symptoms of GORD?
- Heartburn - Regurgitation - Dysphagia - Cough - Hoarseness
31
What are 4 outcomes of GORD
- Oesophagitis - Stricture - Barett's metaplasia - Oesophageal adenocarcinoma
32
How to diagnose GORD?
- 24 hour pH monitoring that defines reflux by seeing if there is acid - Contrast swallow
33
What are the 3 types of treatment for GORD?
- Conservative - Medical - Surgical
34
What are the 3 types of treatment for GORD?
- Conservative - Medical - Surgical
35
What does conservative treatment include?
- Weight loss - Avoid food and alcohol before going to bed - Reduce alcohol - Raise bed by around 30cm
36
What does medical treatment include?
Decrease acid using: - Proton pump inhibitors - Antacids which increase pH - H2 blockers - Alginates (Gaviscon)
37
What does surgical treatment include?
Anti reflux surgery which tightens the gastro oesophageal sphincter so you're less likely to leak acid up into the oesophagus
38
Explain what happens to cells in Barents
They go from normal stratified squamous epithelium to single columnar epithelium
39
Give the difference between squamous cell carcinoma and Adenocarcinoma
Squamous cell carcinomas don't tend to occur as the oesophageal sphincter whereas adenocarcinomas mostly occur at the oesophageal sphincter
40
What is achalasia?
Very tight gastro oesophageal sphincter that doesn't relax because there is a loss of the myenteric plexus at the lower oesophageal sphincter
41
What are 3 possible treatments for achalasia?
- Botox injection at lower oesophageal sphincter - Oesophageal dilation - Surgery - Hellers myotomy