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Neuro2 > motor neuron and radiculopathies > Flashcards

motor neuron and radiculopathies Flashcards

1
Q

infantile spinal musc atrophy

A

Au Rec, hypotonicity, hyporeflex, fatal, tongue fascic, poor suck reflex, abdominal resp

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2
Q

juvenile prox chronic spinal musc atrophy

A

Au Rec, slowly prog, fascic, prox weakness, resembles myopathy

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3
Q

adult onset spinal spinal musc atrophy

A

sporadic, prox, distal weakness, hypoton, hyporeflex

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4
Q

may see frog leg posture

A

infantile spinal musc atrophy

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5
Q

EMG for infantile spinal musc atrophy

A

signs of denervation and fascic

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6
Q

muscle bx for infantile spinal musc atrophy

A

group fiber atrophy

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7
Q

gene for infantile spinal musc atrophy

A

chrom 5 survival motor neuron gene

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8
Q

EMG and bx for juvenile spinal musc atrophy

A

denervation changes, serum CK usually normal

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9
Q

size of SMN2 determines

A

if pt has neonatal (smaller) or juvenile (larger). SNM1 is absent in spinal musc atrophy

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10
Q

progressive bulbar palsy

A

sporadic, fascic, bulbar muscle weakness, rapidly prog, tongue atrophy

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11
Q

ALS

A

mostly sporadic, hyperreflex, spasticitiy, musc atrophy, fascic, tongue atrophy, rapidly prog

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12
Q

progressive lateral sclerosis

A

sporadic, involves only UMN, spasticity, hyperreflex, more benign course than ALS

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13
Q

progressive spinal musc atrophy

A

mostly sporadic, progressive weakness, muscle atrophy, fascic, areflexia

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14
Q

muscle bx for motor neuron dz shows

A

atrophic fibers and fiber grouping

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15
Q

pts should always have ____ before diagnosing ALS

A

MRI

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16
Q

cervical spondylosis can mimic

A

ALS

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17
Q

Kennedy dz

A

gynecomastia, testicular atrophy, LMN syndrome. mut on x chrom. test DNA serum CK may be elevated

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18
Q

Bunina body

A

eosino inclusion seen in ant horn cell neuron - ubiquitin accum. ALS

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19
Q

ALS genes

A

SOD in AD familial - chrom 21; expanded section on chrom 9 - C90RF72

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20
Q

juvenile ALS

A

chrom 2

21
Q

ALS associated with frontotemp dementia

A

chrom 17

22
Q

ALS tx possibilities

A

glu antags - riluzole. Phys therapy. experimental antiox, nerve growth factors, COX2 inh.

23
Q

tx ALS symptoms

A

antidep, bracing, gastrostomy, resp assistance, stool softener, botox, antispastic drugs, antichol for excess saliva

24
Q

GBS (aka acute inflam demy polyneurop)

A

ascending motor weakness, absent muscle stretch reflex

25
Q

Chronic Inflammatory Demyelinating Polyneuropathy (CIDP)

A

steroid treatment effective, also IVIG or plasma exchange

26
Q

GBS tx

A

give IVIG or plasma exchange, no corticosteroids

27
Q

dx CIDP

A

Lumbar puncture and serum test for anti-ganglioside antibodies, EMG to show demy,

28
Q

C1 and Co1 (coccygeal) don’t contain

A

sensory nerve fibers

29
Q

C5

A

deltoid, infraspin, biceps weakness

30
Q

C6

A

wrist extensors, biceps weakness

31
Q

C7

A

triceps weakness

32
Q

disc for C5 inj

A

c4-5

33
Q

disc for C6 inj

A

c5-6

34
Q

disc for c7 inj

A

c6-c7

35
Q

L4

A

iliopsoas, quad weakness (L3-4 disc)

36
Q

L5

A

foot dorsiflex, big toe ext, foot eversion, inversion weakness. L4-5 disc

37
Q

S1

A

foot plantar flexion weakness (L5-S1)

38
Q

95% of HNPs affect

A

L5 or S1

39
Q

clinical fts of radiculop

A

pain - radiating and aggravated by maneuvers that stretch the root

40
Q

spinal percussion helps id

A

disorders involving vertebral bodies

41
Q

abd dig min

A

c8, t1

42
Q

ext poll brevis, ext indic, flex pol longus

A

c8

43
Q

pronator teres, flexor carpi radialis

A

c6,c7

44
Q

glut max and med

A

L5, s1

45
Q

adductor longus, vastus med and lat

A

L3,L4

46
Q

iliacus

A

L2,L3

47
Q

tib anterior

A

L4,L5

48
Q

abd hallucis, soleus

A

S1,2

49
Q

muap

A

motor unit action potential

Neuro2 (6 decks)

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