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endo/repro2 - female repro tract > morphology > Flashcards

morphology Flashcards

1
Q

in ovary

Sertoli or Leydig cells interspersed with stroma.

A

Well-differentiated: Sertoli-leydig Cell Tumors

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2
Q

in ovary

sarcomatous pattern w disorderly disposition of epi cell cords & Leydig cells may be absent.

A

Poorly-differentiated: Sertoli-leydig Cell Tumors

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3
Q
  • Sharply circumscribed, discrete, round, firm, gray-white tumors
  • whorled pattern of smooth mm. bundles resembling the uninvolved myometrium.
  • oval nucleus & long, slender bipolar cytoplasmic processes.
  • Scarce mitotic figures
  • yellow-brown-red areas of softening.
A

Uterine Leiomyoma (fibroids)

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4
Q
  • Exophytic, papillary architecture

- Prominent koilocytic atypia

A

Warty Carcinoma (of vulva)

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5
Q

Larger cysts near the fimbriated end of the tube or in the broad ligaments
 lined with benign, serous (tubal type) epi

A

Hydatids of Morgagni

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6
Q

in ovary

-in the ovarian stroma composed of both fibroblasts & plump spindle cells w lipid droplets.

A

ovarian fibrothecoma

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7
Q

in ovary

  • cells that look like granulosa cells of a developing ovarian follicle.
  • yellow from stored lipids
  • call-exner bodies
A

granulosa cell tumors of ovary

-Call-Exner bodies: small, distinct, gland-like structures filled with acidophilic material.

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8
Q

thinning of epidermis: parchment paper

A

lichen sclerosis leukoplakia

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9
Q

in ovary
 Unilateral tumors
 Large vesicular cells with clear cytoplasm (like seminoma).
 Grow in sheets or cords.
 Scant fibrous stroma infiltrated by mature lymphocytes +/- granulomas

A

dysgerminoma

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10
Q
  • placental infarcts and syncytial knots
  • retroplacental hematomas
  • abn decidual vessels
A

preeclampsia placenta

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11
Q

proliferating, back-to-back, branching glands w nuclear atypia

A

atypical endometrial hyperplasia

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12
Q

prolif of glandular epi w lg, hyperchrimatic nuclei and dark appearance of glands

A

adenocarcinoma of cervix

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13
Q

in ovary
o Extensive mucinous ascites.
o Cystic epi implants on peritoneal surfaces, adhesions, and frequent involvement of the ovaries

A

Pseudomyxoma Peritonei

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14
Q

cowdry bodies

A

HSV

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15
Q

intraepithelial malignancy w cells larger than surrounding keratinocytes

A

extramammary paget dis

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16
Q

Eosinophilic epi metaplasia ~ menstrual epi BUT lacks progesterone dependent morphologic features (glandular secretory changes, stromal predecidualization) bc the corpus luteum does not develop.

A

Anovulatory Cycle

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17
Q

Delicate, friable mass of thin walled, translucent, cystic, grapelike structures with swollen, edematous (hydropic) villi.

A

hydatidiform mole

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18
Q

glandular and squamous epi of cervix

A

adenosquamous carcinoma of cervix

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19
Q

chocolate cysts/endometriomas:

A

endometriosis

-3-5cm cystic masses filled w brown fluid (hemosiderin deposits) from previous hemorrhage

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20
Q

 Only a fraction of the villi are enlarged and edematous.

 Trophoblastic hyperplasia is focal and less marked

A

Partial Mole

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21
Q

in ovary

o Extraembryonic differentiation of malignant germ cells of placental origin.

A

choriocarcinoma

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22
Q
  • Surface epi: viral cytopathic changes (koilocytic atypia).

- Nuclear enlargement, hyperchromasia, cytoplasmic nuclear halo

A

Condyloma Acuminatum (genital wart)

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23
Q

Cells small w oval nuclei and cytoplasmic protrusions (tennis racket shape).
cells (often mistaken for inflamm. Polyps)

A

Embryonal Rhabdomyosarcoma (sarcoma bortyoides)

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24
Q

in ovary
 Glomerulus-like structure with a central blood vessel enveloped by tumor cells in a space lined by tumor cells (schiller-duval body).

A

yolk sac tumor

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25
Q

in ovary
 Solid + cystic areas of growth.
 Epithelium consists of tubular glands resembling endometrium

A

endometriod tumors of ovary (mullerian epithelium)

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26
Q

inreased gland:stroma ratio

-back-to-back w maybe some intervening stroma

A

nonatypical endometrial hyperplasia

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27
Q

cysts lined w bright yellow tissue containing granulosa cells

A

luteal cysts (corpora lutea)

28
Q

o Bulky, polypoid.
o May protrude thru the cervical os.
o Usually consist of adenocarcinoma (glandular) mixed with malignant mesenchymal elements (mm, cartilage, bone, etc).

A

Malignant Mixed Mullerian Tumors (MMMTS) (carcinosarcomas)

29
Q

o Soft, fleshy, yellow-white tumor.
o Large, pale areas of necrosis + extensive hemorrhage.
o Invades underlying myometrium, often penetrating blood vessels.

A

choriocarcinoma

30
Q

-Discrete white (hyperkeratotic) or slightly raised, pigmented lesion w Epidermal thickening

A

VIN (vulvar intraepithelial neoplasia)

31
Q

in ovary
 Solid grey to golden brown.
 Grossly resemble granulosa cell tumors.

A

Sertoli-leydig Cell Tumors

32
Q

in ovary
o Small, multilocular tumors with simple papillary processes.
o Pronounced proliferation of the fibrous stroma under the columnar epi

A

cystadenofibroma

33
Q
  • Exophytic or indurated and ulcerated
  • Small tightly packed basaloid cells
  • Foci of central necrosis
A

Basaloid Carcinoma (of vulva)

34
Q

~small cell carcinoma of lung but on cervix

A

neuroendocrine carcinoma of cervix

35
Q

in ovary
 Complex patterns of growth.
 Widespread infiltration of underlying stroma.
 Marked nuclear atypia, pleomorphism, and multinucleation
 Increased mitotic activity with atypical mitosis.
 Cysts are lined with columnar epi.
 66% are b/l.
 Often involve the surface of the ovary

A

high grade serous tumors of ovary (mullerian epithelium)

36
Q

Multinucleated squamous cells with eosinophilic to basophilic viral inclusions w a ‘ground glass’ appearance (viral cytopathic effect)

A

HSV

37
Q

red glandular epithelium in vagina

A

vaginal adenosis

38
Q
  • invade teh uterine wall or project into the uterine lumen

- nuclear atypia w great mitotic index

A

Leiomyosarcoma

39
Q

plasma cell on bx*

A

chronic endometritis

40
Q

degeneration of basal cells, hyperkeratosis, sclerotic changes

A

lichen sclerosis leukoplakia

41
Q

in ovary

  • tumor w well-diff fibroblasts w scant interspersed collagenous stroma
  • glistening intact ovarian serosa
A

ovarian fibroma

42
Q

in ovary

-in the ovarian stroma composed of plump spindle cells with lipid droplets

A

ovarian thecoma

43
Q

in ovary
 Multiloculated tumors willed with sticky, gelatinous fluid rich in glycoproteins.
 Lined by tall, columnar epi with apical mucin, lacking cilia.
 Most show gastric or intestinal type differentiation.

A

-malignant mucinous tumors of ovary (mullerian epithelium)

44
Q

o Nests + tongues of malignant squamous epi.

o Invade the underlying cervical stroma

A

scc of cervix

45
Q

in ovary

o Normal stroma with nests of neoplastic epi cells resemble urothelium with mucinous glands in the ctr

A

Transitional Cell Tumors (Brenner Tumors) of ovary (mullerian epithelium)

46
Q

in ovary
 Smooth glistening cyst wall with no epi thickening or with small papillary projections.
 Cysts are lined with columnar epi with lots of cilia.

A

benign serous tumors of ovary (mullerian epithelium)

47
Q

Theca cells prolif and the perifollicular zone expands in response to gonadotropins released during preg

A

Theca Lutein Hyperplasia of Pregnancy

48
Q

in ovary
 Resembles hypersecretory gestational endometrium.
 Solid: cells are arranged in sheets or tubules.
 Cystic: cells line the spaces.

A

clear cell carcinoma of ovary (mullerian epithelium)

49
Q
  • cluster of polygonal cellsaround hilar vessels
  • lg, lipid laden leydig cells
  • reinke crystalloids
A

Hilus Cell tumors (pure Leydig cell tumors)

50
Q

Guarnieri bodies

A

Molluscum contagiosum (poxvirus)

51
Q

o Stroma appear neoplastic, while the glands appear reactive.
o Glands may be hyperplastic, atrophic or functional.

A

endometrial polyps

52
Q

in ovary

u/l tumor w itestinal tissue that may be functional (5-HT)

A

Monodermal or Specialized Teratoma of ovary: Ovarian Carcinoid

53
Q

tumor cells Grow as polypoid, rounded, bulky masses = grapelike clusters.

A

Embryonal Rhabdomyosarcoma (sarcoma bortyoides)

54
Q

 Seen in small, atrophic uteri.
 Tumors are large and bulky or invasive into the myometrium.
 Papillary growth pattern.
 ↑ nuclear atypia

A

-Type 2 endometrial serous carcinoma

55
Q

in ovary

-unilocular cysts w hair and sebacisou material, teeth, and calcifications in the stratified squamous wall

A

mature teratoma (benign) of ovary

56
Q

 Marked atypia of the basal layer of the squamous epi
buut Normal differentiation of the superficial layers
 Nests and tongues of malignant squamous epi
 Prominent central keratin pearls

A

keratinizing scc of vulva

57
Q

Loose, fibromyxomatous stroma covered by mucus secreting endocervical glands +/- inflamm.

A

endocervical polyps

58
Q

t cells: band-like infiltrate

A

lichen sclerosis leukoplakia

59
Q

red/blue to yellow/brown nodules on or beneath the mucosa and/or serosal surfaces. (powder burn marks)

A

endometriosis
-from Bleed in response to extrinsic (cyclic) & intrinsic hormonal stimulation
→ extensive fibrous adhesions between structures = obliteration of pouch of Douglas.

60
Q

in ovary

u/l tumor w mature thyroid tissue that may be functional –> hyperthyroidism

A

Monodermal or Specialized Teratoma of ovary: Struma Ovarii

61
Q

psammoma bodies (concentric calcifications)

A

serous tumors of ovary (mullerian epithelium)

62
Q

cyst w clear, serous fluid, lined by gray, glistening mem and outer theca cells

A

cystic ovaria follicles

63
Q

inovary

  • Tumor tissue resembles embryonal and immature fetal tissue.
  • Solid, bulky tumors with a smooth external surface.
  • May see hair, sebaceous material, cartilage, bone, calcification
A

immature malignant teratomas of ovary

64
Q

 Grapelike structures = edematous (hydropic) villi)
 All/most chorionic villi are enlarged.
 Scalloped in shape with central cavitation (cisterns).
 Covered by extensive trophoblastic proliferation of the entire villi circumference.

A

Complete Mole

65
Q
  • Tumor cells may be crowded in a cambium layer beneath vaginal epi.
  • -Or the tumor cells can be within an edematous, loose fribomyxomatous stroma in the deep regions w inflamm.
A

Embryonal Rhabdomyosarcoma (sarcoma bortyoides)

endo/repro2 - female repro tract (8 decks)

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