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endo/repro2 - female repro tract > genes > Flashcards

genes Flashcards

1
Q

TP53

A
  • differentiated vulvar intraepithelial neoplasia (VIN simplex) –> scc of vulva
  • Type 1 endometrial carcinoma (poor prognosis)
  • Type 2 endometrial serous carcinoma
  • Malignant Mixed Mullerian Tumors (MMMTS) (carcinosarcomas)
  • high grade serous tumors of ovary (mullerian epithelium)
  • endometriod tumors of ovary (mullerian epithelium)
  • clear cell carcinoma of ovary (mullerian epithelium)
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2
Q

p16

A

SIL of cervix

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3
Q

PTEN

A

(↑ signaling via PI3K/AKT )

  • endometriosis
  • endometriotic cysts
  • atypical endometriosis
  • endometrial hyperplasia
  • Cowden synd ( increased endometiral an BC)
  • Type 1 endometrial carcinoma
  • Malignant Mixed Mullerian Tumors (MMMTS) (carcinosarcomas)
  • endometriod tumors of ovary (mullerian epithelium)
  • clear cell carcinoma of ovary (mullerian epithelium)
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4
Q

ARID1A

A

(↑ signaling via PI3K/AKT )

  • endometriosis
  • endometriotic cysts
  • atypical endometriosis
  • Type 1 endometrial carcinoma
  • clear cell carcinoma of ovary (mullerian epithelium)
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5
Q

PIK3CA

A
  • Type 1 endometrial carcinoma
  • Malignant Mixed Mullerian Tumors (MMMTS) (carcinosarcomas)
  • high grade serous tumors of ovary (mullerian epithelium) (amplification)
  • clear cell carcinoma of ovary (mullerian epithelium)
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6
Q

KRAS

A
  • Type 1 endometrial carcinoma
  • low grade serous tumors of ovary (mullerian epithelium)
  • malignant mucinous tumors of ovary (mullerian epithelium)
  • clear cell carcinoma of ovary (mullerian epithelium)
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7
Q

PI3K

A

-Type 2 endometrial serous carcinoma

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8
Q

PP2A

A

-Type 2 endometrial serous carcinoma

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9
Q

T(12q14;6p): HMGIC, HMGIY

A

Uterine Leiomyoma (fibroids)

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10
Q

MED12

A
  • Uterine Leiomyoma (fibroids)

- Leiomyosarcoma

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11
Q

BRCA1, BRCA2

A

malignant serous tumors of ovary (mullerian epithelium)

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12
Q

BRAF

A

-low grade serous tumors of ovary (mullerian epithelium)

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13
Q

ERBB2

A

-low grade serous tumors of ovary (mullerian epithelium)

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14
Q

RB deletions

A

-high grade serous tumors of ovary (mullerian epithelium)

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15
Q

OCT3

A

dysgerminoma

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16
Q

OCT4

A

dysgerminoma

17
Q

NANOG

A

dysgerminoma

18
Q

KIT

A

dysgerminoma

19
Q

FOXL2

A

granulosa cell tumor in ovary

20
Q

DICER1

A

Sertoli-leydig Cell Tumors of ovary

endo/repro2 - female repro tract (8 decks)

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