Mood Disorders: Depressive Disorders And Mania Flashcards
Major Depressive Disorder is the blank most disabling disease?
Second, behind heart disease
Two percentages he wants us to know regarding Mood Disorders and Bipolar Disorders and genetics?
10-25% of patients with a Mood Disorder have a first degree relative with a mood disorder
50% of patients with Bipolar Disorder have a first degree relative with a mood disorder
What are the 3 NT to know and how they are changed in depression and mania?
NE function is abnormal in depression
Dopamine is decreased in depression and increased in mania
5HT decreased in depression
What definition to remember about the diagnosis of Major Depressive Episode?
At least 5 of the criteria for a 2 week period with at least one: either depressed mood or loss of interest or pleasure
More bad days than good in 14 days
What is a good definition for the diagnosis of Manic Episode?
Abnormally and persistently elevated, expansive or irritable mood lasting at least 1 week with at least 3 of the criteria symptoms.
What is a good definition for hypomania?
What other mental disorder is hypomania commonly associated with?
Less severe mania, so only 4 days and no psychotic symptoms.
Bipolar type 2
Definition to diagnose Major Depressive Disorder?
One of more major depressive episodes and the ABSENCE of any manic, hypomania or mixed episodes.
What is first line treatment for grief and what to not treat them with right off the bat?
Counseling
Don’t just throw antidepressants at them
What is nortriptyline indicated for?
What does he like Bupropion for?
What did he say about fluoxetine/Prozac as far as discontinuing it?
Elderly patients at night
Young adults who have fatigue and low energy because it is a stimulating antidepressant with very minimal sexual side effects and no weight gain.
Don’t need to taper because it has a 96 hour half life
What did he say is the most effective depression treatment and what is its specific indication?
ECT
Treatment resistant depression
MOA of Ketamine?
Clinical use?
What do they call this type of antidepressant?
What was the effect in patients when taking ketamine?
NMDA blocker
Treatment resistant depression
Rapid acting antidepressant
50% reduction in suicidal thought
What is the other rapid acting antidepressant he spoke of?
It’s administration?
Clinical use?
Spravato
Nasal spray
Treatment resistant depression
Definition to diagnose Dysthymia?
Depressed mood for most of the day for at least 2 years in adults or 1 year in kids but not severe enough to be MDD.
Constant, moderate continuous depression, no suicide or psychotic stuff.
Even though you can use meds, what is the first line treatment for Premenstrual Dysphoric Disorder?
Exercise, diet, relaxation. No meds at first.
