Mood Disorders Flashcards
Mood Disorders
- Bipolar and Related Disorders
- Depressive Disorders

Bipolar and Related Disorders
- Bipolar I Disorder
- Bipolar II Disorder
- Cyclothymic Disorder
- Substance / Medication Induced Bipolar and Related Disorders
- Bipolar and Related Disorder due another Medical Condition
- Other Specified Bipolar and Related Disorders
- Unspecified Bipolar and Related Disorders
DSM 5:
Depressive Disorders
- Major Depressive Disorder
- Persistent Depressive Disorder (Dysthymia)
- Disruptive Mood Dysregulation Disorder
- Premenstrual Dysphoric Disorder
- Substance induced Depression
- Depression due to another medical condition
Bipolar Disorders
vs
Depressive Disorders
Bipolar Disorder ⇒ Manic Episodes (with or without Depressive Episodes) OR Hypomanic Episodes + Depressive Episodes
Major Depression ⇒ only depressive episodes
Bipolar Disorder
Overview
Patients with Bipolar Disorder have:
A single or recurrent manic episodes with or without depressive episodes
or
Hypomanic episodes with depression
Manic Episode
- Distinct period of abnormally & persistent elevated, expansive or irritable mood AND abnormally and persistently increased goal directed activity or energy for 1 week
- During this period, 3 or more of the following (4 if irritable mood)
- Inflated self-esteem or grandiosity
- Decreased need for sleep
- More talkative / Pressure of speech
- Flight of ideas / subjective feeling of racing thoughts
- Distractibility
- Psychomotor agitation
- Excessive involvement in activities which have a high potential for painful consequences
- Mood disturbance sufficiently severe to cause impairment in social occupational functioning or to need hospitalization
- Not due to substance abuse or medical condition
Manic Episode
DIGFAST
DIGFAST
- Distractibility and easy frustration
- Irresponsibility and erratic uninhibited behavior
- Grandiosity
- Flight of ideas
- Activity increased with weight loss and increased libido Sleep is decreased
- Talkativeness
Hypomanic Episode
- Distinct period of abnormally & persistent elevated, expansive or irritable mood AND abnormally and persistently increased goal directed activity or energy for 4 DAYS
- During this period 3 or more of the following (4 if irritable mood)
- Inflated self-esteem or grandiosity
- Decreased need for sleep
- More talkative / Pressure of speech
- Flight of ideas / subjective feeling of racing thoughts
- Distractibility
- Psychomotor agitation
- Excessive involvement in activities which have a high potential for painful consequences
- The episode is associated with unequivocal changes in functioning that is uncharacteristic
- The disturbance is mood and change in functioning is observable by others
- The episode is not severe enough to cause marked impairment in functioning or need hospitalization
- If there are psychotic features, then by definition the episode is manic
- Not due to substance abuse or medical condition
Mania vs Hypomania

Depressive Episode
-
Five (or more) of the following sx have been present during the same 2‐week period and represent a change from previous functioning
At least one of the symptoms is either depressed mood or loss of interest or pleasure- Depressed mood most of the day, nearly every day, as indicated by either subjective report (e.g., feels sad, empty, hopeless) or observation made by others (e.g., appears tearful). (Note: In children and adolescents, can be irritable mood.)
- Markedly diminished interest or pleasure in all, or almost all, activities most of the day, nearly every day (as indicated by either subjective account or observation).
- Significant weight loss when not dieting or weight gain (e.g., a change of more than 5% of body weight in a month), or decrease or increase in appetite nearly every day. (Note: In children, consider failure to make expected weight gain.)
- Insomnia or hypersomnia nearly every day.
- Psychomotor agitation or retardation nearly every day (observable by others, not merely subjective feelings of restlessness or being slowed down).
- Fatigue or loss of energy nearly every day.
- Feelings of worthlessness or excessive or inappropriate guilt (which may be delusional) nearly every day (not merely self‐reproach or guilt about being sick).
- Diminished ability to think or concentrate, or indecisiveness, nearly every day (either by subjective account or as observed by others).
- Recurrent thoughts of death (not just fear of dying), recurrent suicidal ideation without a specific plan, or a suicide attempt or a specific plan for committing suicide.
- The symptoms cause clinically significant distress or impairment in social, occupational, or other important areas of functioning.
- The episode is not attributable to the physiological effects of a substance or to another medical condition.
Depressive Episode
SIGECAPS
Depressed mood or Anhedonia plus:
SIGECAPS
- Sleep
- Interest
- Guilt
- Energy
- Concentration
- Appetite
- Psychomotor
- Suicidal
Bipolar I
“The classic Manic‐Depressive Psychosis”
- The patient has had at least one manic episode
- There may or may not be a history of a major depressive episode
- Vast majority of individuals who meet the criteria for a manic episode will experience a depressive episode in their lifetime

Bipolar II
Characterized by recurring mood episodes consisting of:

At least one hypomanic episode
One or more depressive episode
Bipolar Disorder
Course Specifiers
- Rapid Cycling
- Mixed features
- Melancholia
- Atypical features
- Mood congruent / incongruent psychotic features
- Catatonia
- Peripartum Onset
- Seasonal Pattern
Rapid Cycling
Can be seen in Bipolar I and II
4 or more episodes in the last 12 months which have
met the criteria for mania, hypomania or depressive episode
and are demarcated by full or partial remission

Mixed Features
Mania or Hypomania, with mixed features: The criteria for mania and hypomania are present plus there are depressive symptoms
Depressive episode with mixed features: Full criteria for a major depressive episode with manic or hypomanic symptoms
Melancholia
- Loss of pleasure – Very marked anhedonia
- Lack of reactivity
- Does not feel better even temporarily if something good happens
- Distinct quality of mood
- Mood worse in the morning
- Early morning awakening (at least 2 hours)
- Marked retardation or agitation
- Weight loss
- Excessive or inappropriate guilt
Atypical Features
- Mood reactivity
- Weight gain or increased appetite
- Hypersomnia
- Leaden paralysis
- Long standing pattern of interpersonal rejection sensitivity
Seasonal Pattern
- There is a regular relationship between a mood episode and season
- Not related to psychosocial stressors (anniversaries, unemployment…)
- More likely in Bipolar II than in Bipolar I
- Winter type seasonal pattern is related to latitude (Higher), Age (younger) and Sex (females)
Mood Congruent / Incongruent
Psychotic Features
- Delusions and Hallucinations can be present at any time during a mood episode
-
Psychotic features can be mood congruent or incongruent
-
Mood Congruent: Delusions and hallucinations are consistent with the mood.
- E.g. Grandiose delusions during a manic episode or delusions of guilt during a depressive episode
- Mood Incongruent: The content of the delusions is not consistent with the polarity of the episode
-
Mood Congruent: Delusions and hallucinations are consistent with the mood.
Peripartum Onset
- Onset of symptoms occurs during pregnancy or in the 4 weeks following delivery
- Prevalence 3‐6%
- 50% of “post-partum depression” actually begins during pregnancy
- Psychotic symptoms may be present
Cyclothymic Disorder
-
Duration of symptoms 2 yrs
- 1 yr in children
- Numerous hypomanic symptoms and depressive symptoms that do not meet the criteria for a hypomanic episode or depressive episode
- Mood symptoms have been present for at least half the time in the 2-year period

Major Depressive Disorder
- Meets criteria for a Major Depressive Episode
- There has never been a manic or hypomanic episode
- Not due to substance abuse or another medical condition

Depression vs. Grief
-
Responses to a significant loss may include the feelings of intense sadness, rumination about the loss, insomnia, poor appetite, and weight loss noted in Criterion A, which may resemble a depressive episode
- Ex. bereavement, financial ruin, losses from a natural disaster, a serious medical illness or disability
- Although such sx may be understandable or considered appropriate to the loss, the presence of a major depressive episode in addition to the normal response to a significant loss should also be carefully considered
- This decision inevitably requires the exercise of clinical judgment based on the individual’s hx and the cultural norms for the expression of distress in the context of loss
