Mood disorders Flashcards
- Tricyclics
- Selective Serotonin Reuptake Inhibitors
- Monoamine Oxidase Inhibitors
Antidepressants
Increase the concentration of norepinephrine, serotonin, and/or dopamine in the body - blocking the reuptake of those neurotransmitters ; also occurs when enzyme - monoamine oxidase (MAO) is inhibited at various sites in the nervous system.
Antidepressants - action
Inactivate norepinephrine , serotonin and dopamine
MAO function
Amitriptyline (Elavil)
Tricyclic antidepressant (TCA)
Doxepin ( Tofranil)
Tricyclic antidepressant (TCA)
- Blurred vision
- Constipation
- Urinary retention
- Orthostatic hypotension
- Reduction of seizure threshold
- Tachycardia , arrhytmias
- Photosensitivity
- Weight gain
side effects of Tricyclic antidepressant (TCA)
Citalopram ( Celexa )
Selective Serotonin Reuptake Inhibitors (SSRI) antidepressants
Fluoxetine ( Prozac)
SSRI antidepressants
Paroxentine ( Paxil )
SSRI antidepressants
Sertaline ( Zoloft )
SSRI antidepressants
Escitalopram ( Lexapro )
SSRI antidepressants
- Insomnia, agitation
- Headache ( analgesics )
- Sexual dysfunction
- Serotonin syndrome
side effects of SSRI antidepressants
- Take dose early in the day
- Avoid caffeine
- Relaxation before bed
Insomnia interventions
- Changes in mental status
- Restlessness
- Hyperreflexia
- Myoclonus (muscle twitching )
- Tachycardia, labile BP
- Diaphoresis, shivering, tremors.
Serotonin syndrome
Cyproheptadine
antihistaminic and antiserotonergic agent; treat symptoms of serotonin syndrome
Phenelzine ( Nardil )
MAOI antidepressant
Tranylcypromine sulfate ( Parnate )
MAOI antidepressant
- Hypertensive crisis
- Weight gain
- Changes in cardiac rhythm
- Hypotension
- Sedation
- Insomnia
side effects of MAOI antidepressants
Occurs if the individual consumes foods containing tyramine while receiving MAOI therapy
Hypertensive crisis
- Severe occipital headache
- Palpitations
- Nausea/vomiting
- Nuchal rigidity (neck stiffness )
- Fever, sweating
- Increase in BP, chest pain, coma
Hypertensive crisis
- Discontinue drug
- Monitor vital signs
- Short-acting antihypertensive medication
- External cooling methods to control hyperpyrexia
TX of hypertensive crisis
Aged cheese ; wine, beer; chocolate, colas, coffee, tea, sour cream, smoked and processed meats, beef or chicken liver, canned figs, soy sauce , overripe and fermented foods, pickled herring, raisins, caviar, yogurt, yeast products, broad beans, cold remedies, diet pills.
Do not consume while taking MAOIs
Aged cheese ; wine, beer; chocolate, colas, coffee, tea, sour cream, smoked and processed meats, beef or chicken liver, canned figs, soy sauce , overripe and fermented foods, pickled herring, raisins, caviar, yogurt, yeast products, broad beans, cold remedies, diet pills.
Do not consume while taking MAOIs