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ICM - Psychiatry > Mood Disorders > Flashcards

Mood Disorders Flashcards

1
Q

Three major divisions of mood disorders

A

Depressive Disorders
Bipolar Disorders
Depression associated with medical illness/alcohol/substance abuse

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2
Q

Common symptoms of Major Depressive Episode

A 
Depressed Mood/Irratibiltiy
Anhedonia
Weight Change
Insomnia/Hypersomnia
Phychomotor agitation
Fatigue
Feelings of Worthlessness/Guilt
Diminished ability to concentrate
Suicidal Idealization
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3
Q

Etiology of Major Depressive Disorder

A

Genetic contribution

Variable sensitivity of individual major life stressors

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4
Q

Pathophysiology of Major Depressive Disorder

A

Increased Cortisol/CRH secretion

Hypothesized adaptive changes in 2nd mess. systems and TFs

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5
Q

What is anhedonia?

A

Decrease in enjoyment drawn from activities

often old favorites

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6
Q

Three problems that can influence basically every psychological disorder

A

Sleep
Chronic Pian
Meds w/ psychotropic effects

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7
Q

What is lastitude

A

Inability to initiate things

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8
Q

What is a manic episode characterized by?

A 
Elevated/Irritable Mood
Grandiosity
Little Need for Sleep
Pressured Speech
Distractability
Increase in Activity
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9
Q

Describe a manic episode

A

A distinct period of elevated/irritable mood, lasting at least one week or requiring hospitalization

Look for: Grandiosity, Dec. sleep, talktative, flight of ideas, increased activity and impulsiveness

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10
Q

How is dysphoric mania unique from normal mania

A

It lacks the elevated mood, and instead has nervousness

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11
Q

What occurs in a mixed episode

A

Patient satisfies criteria for both manic episode and major depressive episode over a one week period

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12
Q

Describe a hypomanic episode

A

4 days of elevated mood plus 3-4 symptoms

Mild-moderate impairment OR enhancement of fxn

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13
Q

How is Major Depressive Disorder identified

A

Depressed mood daily for a minimum of two weeks

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14
Q

How is dysthymic Disorder identified

A

Pattern of chronic ongoing mild depressive symptoms

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15
Q

Etiology of MDD

A

Genetic Contribution + variable sensitivity to life stressors

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16
Q

Pathophysiology of MDD

A

Serotonin, NE, and Dopamine

Possible misregulation of cortisol

17
Q

Pharmacological treatment for MDD

A

SSRI
SNRI
TCA (Tricyclic Antidepressant)
MAOI

18
Q

Non-pharmacological treatments for MDD

A

Cognitive Behavioral Therapy
Electroconvulsive Therapy
Transcranial Magnetic Stimulation

19
Q

What might be included in Adjunct/Augmentation therapy for MDD patients

A

Antipsychotics

20
Q

Define Bipolar I

A

Mixed Episodes of mania and depression within the same week

21
Q

Define Bipolar II

A

History of depression with hypomanic episodes

22
Q

Define Cyclothymia

A

Cyclic hypomanic and depressive episodes

23
Q

Pathogenesis of Bipolar Disorder

A

Kindling effect – Over time, episodes are easier to stimulate

24
Q

How is Bipolar mania/hypomania treated?

A

Mood Stabilizers (Lithium carbonate, valproic acid)

25
Q

How is bipolar depression treated?

A

Atypical antipsychotics (Seroquel, Symbyax)

26
Q

Classic examples of medically caused depression

A

Catecholamine depletion or blockade (reserpine, propanolol, cocaine withdrawl)

27
Q

Endocrine related cause of depression

A

Hypothyroidism (or rarely hyper)

Cushing disease

28
Q

Neurologic related cause of Depression

A

CVA (frontal), Parkinson’s, Huntington’s, Alzheimer’s

29
Q

Infectious related cause of Depression

A

HIV, hepatitis, mononucleosis, influenza

30
Q

Neoplastic related cause of depression

A

lung, pancreas, CNS

31
Q

Metabolic related causes of depression

A

Folate or B12 deficiency
high Ca
low Mg

32
Q

Common medical causes of mania

A

Amphetamine/Cocaine
Decongestants
Weight Loss Preps
Dopamine Agonists

33
Q

Endocrine causes of mania

A

hyperthyroidism

34
Q

Neurologic cause of mania

A

Temporal lobe seizures
Temporal lobe CVA
MS
Huntington’s

35
Q

Infectious cause of mania

A

HIV, encephalitis

36
Q

Neoplastic cause of mania

A

brain tumors

37
Q

Metabolic causes of mania

A

Hypocalcemia

Dialysis encephalopathy

38
Q

Latuda is used to treat

A

Bipolar I

39
Q

Average bipolar age of onset?

unipolar depression?

A

20

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ICM - Psychiatry (8 decks)

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