Mood Disorders Flashcards
__________ attach to the center of the serotonin transporter
protein and lock it into a shape that prevents serotonin from
binding to it
SSRIs
__________ block the enzyme monoamine oxidase, a
presynaptic enzyme that metabolizes serotonin into inactive
forms
MAOIs
As a result of low brain-derived neurotrophic factor (BDNF),
many people with depression have a smaller__________, which leads to impaired learning and reduced
production of new neurons in this area
Hippocampus
Most studies have found a relationship between depression and
increased activity in __________, which is stable over the years
despite changes in depression symptoms
The right prefrontal cortex
Most people with depression have lower than average levels of
__________, which is important for synaptic plasticity, learning,
and growth of new neurons in the hippocampus
Brain-derived neurotrophic factor (BDNF)
__________ operates by blocking the transporter proteins that
reabsorb serotonin, dopamine, and norepinephrine into the
presynaptic neuron after their release.
Tricyclics
One example of this is Bupropion (Wellbutrin), which inhibits
reuptake of dopamine and, to some extent, norepinephrine, but
not serotonin
Atypical antidepressants
Difficulty concentrating, memory problems, negative thinking patterns.
Cognitive problems
___________ aid in the survival, growth, and connections of
neurons
Neurotrophins
_________ block reuptake of both serotonin and norepinephrine.
Unlike other antidepressants, these can improve certain aspects
of memory
SNRIs
Upon being diagnosed with one mental illness, the person’s
risk of developing another mental health condition increases. This is
known as:
Comorbidity
Studies of people without depression have found a strong
relationship between happy mood and increased activity in
__________
The left prefrontal cortex
The short form of the serotonin transporter gene increases
__________ of almost any type, good or bad
Emotional reactivity
For people with __________, increasing numbers of stressful
events lead to a major increase in the probability of depression.
Two short forms of the serotonin transporter gene
In individuals with major depression, __________ becomes less
responsive to reward
The nucleus accumbens
