Mood Disorders Flashcards

1
Q

DMDD cannot coexist with which other diagnoses? 3

A

Oppositional defiant
Intermittent explosive
Bipolar

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2
Q

DMDD diagnostic criteria symptoms

A

Recurrent temper outburst manifested verbally and or behaviorally grossly out of proportion in intensity or duration to the situation or provocation

Inconsistent with developmental level

Mood between temper outbursts is persistently irritable or angry most of the day, nearly every day, observable by others

At least 2 settings, severe in at least 1

Symptoms do not occur exclusively during an episode of MDD

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3
Q

DMDD age of diagnosis limits

A

No initial diagnosis prior to age 6 or after age 18

Age of onset prior to 10 years of age

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4
Q

DMDD timing/length of symptoms

A

Temper outbursts 3 or more times per week

Irritable or angry mood most of the day nearly every day observable by others

At least 12 months

No period of 3 or more consecutive months without all of the symptoms

No period longer than 1 day meeting full criteria for manic or hypomanic episode

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5
Q

DMDD 1 Core feature with 2 manifestations

A

Chronic, severe persistent irritability

  1. Frequent severe temper outbursts
  2. Chronic, persistently irritable or angry mood between outbursts. Mood is Characteristic of the child
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6
Q

Difference of irritable mood in DMDD versus bipolar

A

Bipolar is episodic

DMDD irritability is chronic

Expensive mood and grandiosity common in mania, not in DMDD

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7
Q

DMDD conversion

Common

Uncommon

A

Very low conversion to bipolar

Increased risk for unipolar depression and anxiety disorders in adulthood

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8
Q

DMDD vs Bipolar gender prevalence

A

Bipolar is gender equal

DNDD predominately male

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9
Q

DMDD versus pediatric bipolar functional consequences. Different or equal?

A

Levels of dysfunction are generally comparable

For both disorders in children dangerous behavior, suicidal ideation or suicide attempts, severe aggression and psychiatric hospitalizations are common

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10
Q

DMDD common psych Comorbidities

A

ODD most common

ADHD, anxiety disorders, autism

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11
Q

If a child needs the diagnostic criteria for DMDD & ODD, which diagnosis should be made?

A

DMDD

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12
Q

Is it more common for a child with ODD to also meet criteria for DMDD or for a child with DMDD to meet the criteria of ODD as well?

A

It is more common for a child with DMDD to also meet criteria for ODD. Only the diagnosis of DMDD should be made. Most children with ODD do not additionally meet the criteria for DMDD

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13
Q

2 Key differences between DMDD and IED

A
  1. DMDD requires persistent disruption in mood between outbursts, IED does not
  2. IED symptoms at least 3 months

DMDD at least 12 months

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14
Q

MDD: episode considered recurrent when there is a period of how many consecutive months between separate episodes in which criteria are not met for MDD

A

2 months

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15
Q

Symptoms of MDD must be present nearly every day with the exception of which two symptoms?

A

Weight change

Suicidal ideation

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16
Q

Define MDD remission

A

2 or more months with no symptoms or only one or two symptoms to no more than a mild degree

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17
Q

2 in 5 individuals with MDD Begin recovery within 3 months of onset, 4 in 5 within 1 year

During what decade does incidence of MDD peak?

How much higher are the rates of depression in females vs males?

2 symptoms more common in younger individuals

Symptom more common in elderly

A

20’s

1.5-3x, begins in adolescence

No clear differences by gender in phenomenology, course or treatment response in depression

Hypersomnia, hyperphagia

Melancholic features (psychomotor disturbances)

18
Q

What temperament is one of the most established risk factor for depression?

What percent of depression cases are considered to be caused by genetics, especially a specific personality trait?

A

Neuroticism

40%, again neuroticism

19
Q

Risk factors for increased risk for completed suicide

Most consistently described risk factors for suicide?

What personality disorder markedly increases risk for future suicide attempts?

A

Male sex, being single or living alone, persistent feelings of hopelessness

Past history of suicide attempts or threats

Borderline

20
Q

In the United States and cross culturally what complaint is the most uniformly reported in MDD and is a major reason why patients present for care?

A

Insomnia, loss of energy

21
Q

To meet a diagnosis for MDD symptoms must cause functional impairment (e.g., social, occupational) OR

A

Clinically significant distress

22
Q

In MDD, can psychomotor agitation or retardation be subjective, observable by others, or both?

A

Must be observable by others, Subjective reports do not count

23
Q

Diagnosis of persistent depressive disorder PDD (dysthymia)

Name Essential feature with associated symptoms

Which 3 MDD symptoms are not included in PDD?

A

Depressed mood

  1. Poor appetite or over eating
  2. Insomnia or hypersomnia
  3. Low energy or fatigue
  4. Low self-esteem
  5. Poor concentration or difficulty making decisions
  6. Feelings of hopelessness

Anhedonia, Psychomotor agitation or retardation, suicidality

24
Q

Number and Timing of PDD symptoms

A

2

Depressed mood, or irritable mood in children, PLUS
2 symptoms
2 years (1 in peds)
symptom-free for no more than 2 months

25
Q

Major childhood risk factors for PDD

A

Parental loss or separation

26
Q

Define response in MDD treatment

A

At least 50% reduction of symptoms

27
Q

Define MDD recovery

What is the return of symptoms called during recovery?

A

Symptom-free for at least 6 months and beyond

Recurrence

28
Q

Define MDD partial and full remission

What is the return of symptoms called during remission?

A

Partial remission: less than 2 months without any MDD symptoms OR symptoms are present without meeting full criteria

Full remission: ZERO MDD s/s for 2-6 months (6 months and beyond is recovery)

Relapse

29
Q

Dysfunction in which neurotransmitter may cause a reduction in positive affect (depressed mood, anhedonia)?

A

Dopamine

30
Q

Dysfunction in which neurotransmitter may cause an increase in negative affect (anxiety, irritability)?

A

Serotonin

31
Q

Dysfunction of which neurotransmitter is implicated in both decreased positive affect and increased negative affect?

A

Norepinephrine

32
Q

True or false

Higher concentrations of several inflammatory markers including TNF alpha, interleukin six and interleukin one, and CRP may be found in patients with depression. Both cytokines and cytokine inducers can cause symptoms of depression.

A

True

33
Q

Estrogen fluctuations cause the Vasomotor symptoms of Perimenopause. Estrogen fluctuations lead to dysregulation of which two neurotransmitter systems that are thought to mediate both vasomotor symptoms and depression?

Which class of antidepressants addresses both depression and vasomotor symptoms?

A

SE & NE

SNRI

34
Q

Antagonism of which 2 receptors is thought to contribute to weight gain

A

5HT-2C

H1

35
Q

Tyramine, A breakdown product of the amino acid tyrosine, should be avoided while taking MAOI anti-depressants with the exception of?

List foods with high tyramine content

A

Trans dermal and low-dose selegiline
(MAOI B)

Dried, aged, smoked, fermented or spoiled meat, poultry and fish

Broad bean pods

Aged cheeses

Tap and unpasteurized beer

Marmite

Soy products, tofu
Sauerkraut, kimchee
Banana peel and overripe banana

36
Q

Tricyclic antidepressants block VSSC in both brain and the heart. In OD This can lead to?

A

Cardiac arrhythmia, cardiac arrest, seizure, coma

37
Q

Which SGAs are approved as adjuncts to SSRIs and SNRIs in treating MDD?

A

Aripiprazole, brexpiprazole (Rexulti), quetiapine XR, olanzapine in combination with fluoxetine

38
Q

Which three drugs are approved for major depression and bipolar disorder

A

Olanzapine with fluoxetine, lurasidone, Quetiapine

39
Q

What is the most common manic/hypo manic symptom exhibited during a major depressive episode with mixed features?

A

Psychomotor agitation

40
Q

What manic symptoms are most rarely seen in patients With mixed features during a major depressive episode?

A

Decreased need for sleep, inflated self-esteem, elevated mood, and high-risk behavior

41
Q

The two most useful factors for determining if a current depressive episode is indicative of unipolar or bipolar depression are?

A

Family history and input from someone close to the patient

42
Q

Name an STD that can cause depressive symptoms and name the screening and confirmatory tests

A

Syphilis. Cause is treponema pallidum

RPR and VDRL screen for syphilis
A specific treponemal Test is required for diagnosis