Mood/Affective Disorders Flashcards

You may prefer our related Brainscape-certified flashcards:
1
Q

MDD RF

A

FAMILY hx
female
20-40s

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

MDD definition

A

depressed mood or anhedonia (loos of pleasure) or interest in activities with >5 associated symptoms for at least 2 weeks

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

MDD associated symptoms

A

fatigue, insomnia/hypersomnia, guilt/worthlessness, thoughts of death/suicide, psychomotor agitation, significant weight change, appetite change

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

somatic MDD symptoms

A
constipation 
HA
skin changes
chest/abdominal pain 
cough/SOB
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

MDD subtypes

A
  1. seasonal affective d/o
  2. atypical depression
  3. melancholia
  4. catatonic depression
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

seasonal affective d/o

A

presence of depressive symptoms at the same time of year

tx: SSRI, Wellbutrin, light tx

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

atypical depression

A

typical MDD but mood reactivity - elevated mood in response to good things

significant weight gain/increased appetite, hypersomnia, heavy/leaden feelings, oversensitivity to rejection

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

tx of atypical depression

A

MOA inhibitors

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

melancholia

A

anhedonia, lack of mood reactivity, depression ,severe weight loss, guilt, sleep issues

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

catatonic depression

A

motor immobility, stupor and extreme withdrawal

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

who has higher suicide rate?

A

detailed plan, white males >45, concurrent substance abuse

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

principal tx in MDD

A

psychotherapy

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

medications first line

A

SSRIs

need to be taken 3-6 weeks to determine efficacy

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

MDD that fails to respond to tx, what option?

A

ECT

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

SSRI MOA

A

inhibit CNS uptake of serotonin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

SSRI indication

A

first line for anxiety and depression

easy dosing, less SEs, low toxicity

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

who does NOT get citalopram?

A

long QT syndrome

AKA celexa

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

s/es of SSRI

A

GI upset, sexual dysfunction, HA, changes in energy

CAN cause suicidal thoughts

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

serotonin syndrome

A

acute AMS seizures, restlessness, diaphoresis, tremor, hyperthermia, n/v/abdominal pain, mydriasis, tachycardia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

SNRI

A

inhibition of serotonin, norepinephrine, and dopamine reuptake

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

indications of SNRI

A

firt line in its with significant fatigue or pain syndrome in depression

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

SSNRI s/es

A

hypertension, dizziness, hyponatremia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
23
Q

caution SSNRI

A

MAOI use. renal/liver issues, seizures

increased risk of serotonin syndrome if used with St. John’s Wort

24
Q

TCA MOA

A

inhibit serotonin and norepinephrine reuptake

25
Q

TCA indications

A

depression, insomnia, diabetic neuropathy, post-hepatic neuralgia, migraine, fibromyalgia,

26
Q

why don’t we use TCAs that much

A

side effect and severe toxicity with One Direction

27
Q

TCA s/es

A

anticholinergics, sedation, weight gain, prolonged QT, sinus/wide complex tachycardia, neuropathy symptoms, ARDS, SIADH

28
Q

tx for TCA toxicity

A

sodium bicarb

29
Q

indicator of TCA OD

A

wide complex tachycardia

prolonged QT

30
Q

tetracyclic compoiunds MOA and indication

A

enhances noradrenergic and serotonergic activity

indicated in depression, less sexual issues, can be used with trazadone

31
Q

s/es of tetracyclic cmpds

A

section, dry mouth, constipation

c/I with MAO I

32
Q

bupropion hydrochloride MOA/indication

A

inhibits dopamine, norepinephrine uptake

indication for depression and smoking

33
Q

s/es bupropion hydrochloride

A

seizures, agitation, anxiety, weight loss HTN,

LESS GI AND SEXUAL issues

34
Q

C/I bupropion hydrochloride

A

seizure d.o and eating disorder

drug ETOH detox

35
Q

MAO I

MOA and indication

A

blocks NT breakdown

indicated in refractory depression

36
Q

SEs of MAOI

A

insomnia, anxiety, hypotension, weight gain, sexua

hypertensive crisi

37
Q

MAOI CI

A

serotonin syndrome if used with SSRI

may cause delirium and hypertension if with TCA

38
Q

trazodone

A

antidepression, anti anxiety, hypnotic affects

s/es: section and cardiac arrhythmias

39
Q

Bipolar I

A

> 1 manic/mixed episode, cycles with occasional depressive episodes

40
Q

RF of Bipolar I

A

family history strongest risk factor

41
Q

mania

A

abnormal and persistently elevated, expansive, or irritable mood

lasts 1 week

marked impairment of social/occupational function

42
Q

mania mood

A

euphoric, irritable, labile, dysphoric

43
Q

mania htinking

A

racing, flight of ideas, disorganized, easily distracted, expansive, grandiose

44
Q

mania behavior

A

physical hyperactivity, pressured speech, decreased need for sleep

increased impulsivity, excessive involvement in pleasure activity

45
Q

management of Bipolar I

A

mood stabilizers (lithium 1st line, valproic acid, carbamazepine)

Haldol/benzos if manic (psychosis or agitation)

46
Q

antidepressants and Bipolar

A

can precipitate mania

47
Q

bipolar II

A

> 1 hypomanic episode + >1 MDD episode

mania or mixed episodes absent

48
Q

hypomania

A

similar to manic

elevated, expansive or irritable mood x 4+ days

NO marked impairment, no psychosis, no hospitalization

49
Q

Management of acute mania Bipolar II

A

lithium**

also antipsychotics and vends

50
Q

management of depression in Bipolar II

A

lithium

valproate or carbamazepine

51
Q

persistant depressive disorder

A

chronic depressed mood >2 years

more mild than MDD but

no mania symptoms, patients can function

typicall progresses over time

52
Q

clinical manifestations of dysthymia

A
  1. loss of interest, withdrawal, pessimism
  2. chronic depressed mood >2 yrs, “I’ve always been this way,” no symptom free periods
  3. at least 2 of the MDD symptoms met
53
Q

tx of dysthymia

A

SSRIs and psychotherapy

can also try SNRI, Bupropion, TCAs and MOA

54
Q

cyclothymic disorder

A

similar to bipolar II but LESS SEVERE

prolonged period of milder elevations and depressions in mood

55
Q

cyclothymic d/o manifestations

A
  1. recurrent hypomanic symptoms that don’t meet hypomania criteria that CYCLE with relatively mild depression

AT LEAST 2 years

56
Q

tx of cyclothymic d/o

A

mood stabilizers and neuroleptics