Mood/Affective Disorders Flashcards
MDD RF
FAMILY hx
female
20-40s
MDD definition
depressed mood or anhedonia (loos of pleasure) or interest in activities with >5 associated symptoms for at least 2 weeks
MDD associated symptoms
fatigue, insomnia/hypersomnia, guilt/worthlessness, thoughts of death/suicide, psychomotor agitation, significant weight change, appetite change
somatic MDD symptoms
constipation HA skin changes chest/abdominal pain cough/SOB
MDD subtypes
- seasonal affective d/o
- atypical depression
- melancholia
- catatonic depression
seasonal affective d/o
presence of depressive symptoms at the same time of year
tx: SSRI, Wellbutrin, light tx
atypical depression
typical MDD but mood reactivity - elevated mood in response to good things
significant weight gain/increased appetite, hypersomnia, heavy/leaden feelings, oversensitivity to rejection
tx of atypical depression
MOA inhibitors
melancholia
anhedonia, lack of mood reactivity, depression ,severe weight loss, guilt, sleep issues
catatonic depression
motor immobility, stupor and extreme withdrawal
who has higher suicide rate?
detailed plan, white males >45, concurrent substance abuse
principal tx in MDD
psychotherapy
medications first line
SSRIs
need to be taken 3-6 weeks to determine efficacy
MDD that fails to respond to tx, what option?
ECT
SSRI MOA
inhibit CNS uptake of serotonin
SSRI indication
first line for anxiety and depression
easy dosing, less SEs, low toxicity
who does NOT get citalopram?
long QT syndrome
AKA celexa
s/es of SSRI
GI upset, sexual dysfunction, HA, changes in energy
CAN cause suicidal thoughts
serotonin syndrome
acute AMS seizures, restlessness, diaphoresis, tremor, hyperthermia, n/v/abdominal pain, mydriasis, tachycardia
SNRI
inhibition of serotonin, norepinephrine, and dopamine reuptake
indications of SNRI
firt line in its with significant fatigue or pain syndrome in depression
SSNRI s/es
hypertension, dizziness, hyponatremia