Monobactams

Question 1

General info

Answer 1

synthetic monocyclic B-lactam
Aztreonam is the ONLY current agent

Same characteristics of carbapenems, except ONLY binds to PBP3 which is ONLY in gram-negative aerobes. This inhibits second to last step in peptidoglycan crosslinking

Question 2

Gram negative coverage

Answer 2

Kind of like 3rd gen ceph coverage
PEKHEN, salmonella, shigella, citrobacter

**Pseudomonas aeruginosa (target)

Question 3

CSF uses

Answer 3

Penetrates the CSF in presence of inflamed meninges

Question 4

Elimination

Answer 4

excreted in the urine (dose adjust)

Short half life of 1-2 hours

Question 5

Clinical uses of aztreonam

Answer 5

people with significant PCN allergy (anaphylactic)

intraabdominal infections due to susceptible gram -

Question 6

Hypersensitivity

Answer 6

NO cross reactivity with PCN!