Monobactams Flashcards
0
Q
Cross allergenicity of PCN with monobactam…
A
No known cross allergenicity
But likely cross allergenicity with ceftazidme(3rd gen) because of structural similarities
1
Q
Monobactam SAR Aztreonam disodium (Azactam)
A
Not fused with another ring (not essential for activity)
Synthetic
Parenteral
Di-sodium salt
Exocyclic sulfur. Sulfamic (H3NSO3) group replaces Carboxylic acid of PCN
Has methoxime (beta lactamase resistance)
Strong affinity for PBP3
Antibacterial activity against gram(-)
