Bacterial Cell

Question 0

An example of PBP

Answer 0

Transpeptidase which is the target for beta Lactam antibiotics

Question 1

Proteins in the cell membrane

Answer 1

Important for cell wall remodeling and formation

Target for penicillins and are called penicillin binding proteins(PBP)

Question 2

Gram (-) Bacteria components

Answer 2

Thin peptidoglycan layer
Double membrane
Wide periplasmic space
LPS layer (outer membrane, exterior to peptidoglycan layer)
Beta lactamase secreted within cell

Question 3

Gram (+) Bacteria components

Answer 3

Thick peptidoglycan layer
Single membrane, no LPS layer
Techoic acid present in peptidoglycan
Thin or no periplasmic space
Beta lactamase secreted outside of cell

Question 4

Porins (aqueous channels)

Answer 4

Located in in outer LPS layer of gram (-) bacteria that allows for some antibiotics to enter bacteria

Question 5

Techoic acid and lipotechoic acid

Answer 5

Glycophosphate in peptidoglycan layer of gram (+) bacteria
Major cell surface antigens
Lipotechoic acid is embedded all the way through peptidoglycan layer

Question 6

Glycan

Answer 6

Large number of monosaccharides linked glycosidically

Or modified sugar residues, NAM and NAG

Question 7

Peptidoglycan

Answer 7

Peptide +glycan
In both gram(-) and gram (+) bacteria
Composed of n-acetylmuramic acid (NAM) and n-acetyl glucosamine acid (NAG) that form sheets through cross linking peptide bonds on NAM molecules

Question 8

Transglycosylase

Answer 8

Enzyme that catalyzes glycosidic bonds of NAM-NAG formation of glycan portion of peptidoglycan layer

Question 9

Transpeptidase

Answer 9

Catalyzes the cross-linking step in forming peptidoglycan layer