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PHRM 865 Exam 2 > Monobactams > Flashcards

Monobactams Flashcards

1
Q

MOA

A

Inhibit cell wall synthesis by inhibiting PBP

Specifically PBP-3 which allows for enhanced Gram (-) activity

Bactericidal–>Time-dependent

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2
Q

MOR

A

B-lactamase production: Klebsiella, Enterobacter, Pseudomonas

Decreased permeability due to hydrolysis of B-lactams

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3
Q

Spectrum of activity

A

Gram (-) aerobes

Pseudomonas aeruginosa

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4
Q

Distribution

A

Widely distributed into tissues and fluids

Aztreonam can penetrate the CSF in the presence of inflamed meninges–> MENINGITIS

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5
Q

Elimination

A

Eliminated unchanged in the urine

Dose adjustments in renal insufficiency

t1/2= 1.3-2.2 hours

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6
Q

Clinical uses

A

Gram (-) aerobes

Pseudomonas aeruginosa

Can be used in patients who have had a significant penicillin allergy

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PHRM 865 Exam 2 (19 decks)

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