Antibiotic specific features

Question 1

Antibiotics that interact with warfarin

Answer 1

FQs
Erythromycin and Clarithromycin
TMP-SMX
Metronidazole

Question 2

Antibiotics that cannot be used in pregnancy

Answer 2

FQs
Televancin
Tetracyclines and tetracycline analogs
TMP-SMX
Metronidazole

Question 3

Antibiotics that do NOT require renal dose adjustments in renal insufficiency

Answer 3

Nafcillin
Oxacillin
Ceftriaxone
Cefoperazone
Moxifloxacin
Erythromycin, Azithromycin
Quinipristin/Dalfopristin
Linezolid/Tedizolid
Oritavancin
Doxycycline, Minocycline
Tetracycline analogs
Polymyxin B/colistin
Clindamycin

Question 4

Antibiotics that are not removed via hemodialysis

Answer 4

Nafcillin
Oxacillin
FQs
Macrolides
Clindamycin
Daptomycin

Question 5

Which antibiotics can penetrate the CSF?

Answer 5

Parenteral cefuroxime with inflamed meninges and parenteral 3rd/4th generation

Meropenem
Aztreonam
Vancomycin
Linezolid
TMP-SMX
Metronidazole

Question 6

Which antibiotics interact with divalent and trivalent cations?

Answer 6

FQs
Affects absorption of tetracyclines/tetracycline analogs

Question 7

Which antibiotics cause QTc prolongation and tosades?

Answer 7

FQs
Macrolides
Televancin

Question 8

Bactericidal–>Time-dependent

Answer 8

B-lactams
Vancomycin
Dalbavancin
TMP-STX

Question 9

Bactericidal–> Concentration-dependent

Answer 9

FQs
Aminoglycosides
Daptomycin
Televancin
Oritavancin
Polymyxins
Metronidazole

Question 10

Bacteriostatic–>Time-dependent

Answer 10

Macrolides (azithromycin may be concentration-dependent vs some organism)

Synercid
Linezolid
Tetracyclines
Tetracycline analogs
Clindamycin

Question 11

Bacteriostatic–>Concentration-dependent

Answer 11

Tedizolid

Question 12

Dose adjustments in hepatic impairment

Answer 12

Tetracycline analogs
Metronidazole