Mono Case-Johns/Skildum

Question 1

Clinical Syndrome

Answer 1

• Fever
• Pharyngitis
• Adenopathy
• Malaise
• Atypical Lymphocytosis

Question 2

Complications

Answer 2

Splenomegaly
Hepatomegaly
Jaundice
Splenic rupture or infarction

Question 3

Incidence

Answer 3

Highest rates 10-19 yrs

Uncommon over age 30

Question 4

Epstein Barr Virus

Answer 4

Replicates in lymphocytes

• transferred by saliva
• Incubates 4-8 weeks

Question 5

Hoagland Criteria for diagnosis

Answer 5

50% lymphocytes
10% atypical lymphocytes
Fever, pharyngitis, adenopathy

Question 6

Monospot

Answer 6

Red cell agglutination

Question 7

Cytomegalovirus (CMV)

Answer 7

Herpes virus
80% of population has had it. usually unapparent
Worry about newborns and immunocompromised

Question 8

CMV induced mononucleosis

Answer 8

Symptoms are same as EBV mono

Causes elevated liver enzymes 1

Question 9

Have HIV and get CMV? OH NO!

Answer 9

-CD4 T-cell count

Question 10

CMV syndrome in kidney transplant pts

Answer 10

fever
leukopenia
atypical lymphocytes
hepatomegaly
myalgia
arthralgia

Question 11

Mono treatment

Answer 11

supportive care, hydration, oral lidocaine

Corticosteroids if edema affects breathing
30% have group A beta hemolytic strep
-no sports for 3-4 weeks

Question 12

Uncommon complication of mono syndrome?

Answer 12

Splenic infarction

-can cause hypercoagulative state