Molecules Flashcards
1
Q
PGI2
A
- vasodilation
- increased vascular permeability
- inhibit platelet aggregation
2
Q
PGD2
A
- vasodilation
- increased vascular permeability
3
Q
PGE2
A
- vasodilation
- increased vascular permeability
- pain
- fever
4
Q
TXA2
A
- vasoconstriction
- platelet aggregation
5
Q
LTB4
A
- attracts (chemotaxis) and activates neutrophils
6
Q
LTC4
A
- vasoconstriction
- bronchospasm
- increased vascular permeability
7
Q
LTD4
A
- vasoconstriction
- bronchospasm
- increased vascular permeability
8
Q
LTE4
A
- vasoconstriction
- bronchospasm
- increased vascular permeability
9
Q
Lipoxins
A
inhibit neutrophil chemotaxis and adhesion
10
Q
acute inflammation player
A
- TNF
- IL-1
- IL-6
11
Q
TNF
A
- activate endothelium & induce secretion of other cytokines and chemokines
- promote systemic inflammatory state
- metabolic wasting
12
Q
IL-1
A
- activate endothelium & induce secretion of other cytokines and chemokines
- promote systemic inflammatory state
13
Q
IL-6
A
promote systemic inflammatory state
14
Q
chronic inflammation players
A
- IFN-y
- IL-12
- IL-17
15
Q
negative feedback to downregulate inflammation
A
- IL-10
- TGF-B
