Molecular/Genetics

Question 1

Pleomorphic adenoma

Answer 1

PLAG1

Question 2

Mucoepidermoid Ca

Answer 2

CRTC1-MAML2

Question 3

Secretory Ca

Answer 3

ETV6-NTRK3

Question 4

Adenoid cystic ca

Answer 4

MYB overexpression ( MYB-NFIB fusion)

Question 5

Polymorphous low grade AdenoCa

Answer 5

PRKD1 fusion

Question 6

Basal cell adenoma/AdenoCa

Answer 6

CTNNB1 mutation

Question 7

Clear cell carcninoma (salivary)

Answer 7

EWSR1

Question 8

Congenital mesoblastic nephroma, cellular variant

Answer 8

ETV6-NTRK3

Question 9

Infantile fibrosarcoma

Answer 9

ETV6-NTRK3

Question 10

Embryonal Tumour with Multilayered Rosettes

Answer 10

C19MC amplified

Question 11

Well diff liposarc and De-diff liposarc

Answer 11

MDM2 amplification

Question 12

Myxoid liposarcoma

Answer 12

FUS-DDIT3 fusion

Question 13

Low grade fibromyxoid sarcoma

Answer 13

FUS-CREB3L2 fusion

Question 14

Angiomatoid fibrous histiocytoma

Answer 14

EWSR1-CREB1 fusion

Question 15

Synovial sarcoma

Answer 15

SSX-SS18 fusion

Question 16

Clear cell sarcoma

Answer 16

EWSR1-ATF1

Question 17

Extra-skeletal myxoid chondrosarcoma

Answer 17

EWSR1-NR4A3

Question 18

DSRCT

Answer 18

WT1-EWSR1

Question 19

Ewings sarcoma

Answer 19

EWSR1-FLI1 or EWSR1-ERG

Question 20

Alveolar soft part sarcoma

Answer 20

TFE3

Question 21

Intramuscular myxoma

Answer 21

GNAS

Question 22

spermatocytic tumour

Answer 22

CD117+
SALL4+
NSE+
CK18+
Neg: Oct3/4, PLAP, B HCG, AFP, CEA

Question 23

GCNIS

Answer 23

OCT3/4 and D2-40 + (normal germ cells negative)

Question 24

Fibrous dysplasia

Answer 24

GNAS mutation

Question 25

Osteoblastoma

Answer 25

FOS and FOSB

Question 26

ABC

Answer 26

USP6

Question 27

Mesenchymal chondrosarcoma

Answer 27

HEY1-NCOA2

Question 28

Epithelioid haemangioendothelioma

Answer 28

CAMTA1

Question 29

Pulmonary LCH

Answer 29

BRAF V600E

Question 30

Gastroblastoma

Answer 30

MALAT1-CLI fusion

Question 31

Fibrous dysplasia

Answer 31

GNAS mutations

Question 32

Osteoid osteoma/Osteoblastoma

Answer 32

FOS rearrangement

Question 33

Solid pseudopapillary tumour

Answer 33

CTNNB1 mutation

Question 34

Paediatric ependymoma

Answer 34

RELA fusion

Question 35

High grade meningioma

Answer 35

BAP1 loss

Question 36

Clear cell ependymoma

Answer 36

RELA fusion - tested using IHC for L1CAM IHC