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Pathology > IHC > Flashcards

IHC Flashcards

1
Q

Perineurioma

A

EMA(+), claudin-1 (+), GLUT-1(+)
Variable CD34(+)
Negative for S100 protein, keratin, SMA, desmin, MUC4

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2
Q

MPNST

A

S100 and SOX10 (but both only partial +, never diffuse, both may be -ve)
H3K27me3 LOSS

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3
Q

Synovial Sarcoma

A

TLE1 (sensitive but not specific)

SS18-SSx and SSX c-terminus now have IHC

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4
Q

Leydig cell tumour

A

Inhibin +
Calretinin +
Melan A +
WT1 +

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5
Q

Yolk sac tumour

A 
CK +
ALP +
SALL4 +
PLAP +
Glypican 3+
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6
Q

Embryonal carcinoma

A

CD30+
OCT3/4+
PLAP and SALL4 +

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7
Q

Acinic cell carcinoma

A

PAS+ granules (diastase resistant)
DOG1 +
S100 -
Mammoglobin -

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8
Q

Secretory carcinoma (salivary gland)

A

mammoglobin +
S100+
p63 -
DOG1 -

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9
Q

Polymorphous carcinoma, low grade

A

p63 +, S100+, SOX10 +, panCK

p40 -

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10
Q

Thymoma

A

CK7 +, CD15+ (Type A)
BCL2+ (Type A and C)
CK5/6

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11
Q

Thymic carcinoma

A

CK18, CD5, CD117, MUC1, GLUT1 +

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12
Q

Epithelioid hemangioendothelioma

A

CAMTA1 +

Also usually vascular markers +

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13
Q

Infantile hemangioma

A

GLUT1 +

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14
Q

Low grade fibromyxoid sarcoma

A

MUC4 +

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15
Q

Epithelioid sarcoma

A

CK+
EMA+
CD34 +/-
Loss of INI1

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16
Q

Extrarenal rhabdoid tumour

A

CK +
EMA +
INI1 loss

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17
Q

Pituitary adenoma

A

General Neuroendocrine markers +
Hormones: GH, PRL, TSH-β, FSH-β, LH-β, ACTH
Loss of acinar structure on reticulin stain

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18
Q

Mycosis fungoides

A

CD3 and CD4+
CD7 -
May lose other T cell markers eg CD5
Clonal TCR gene rearrangements

19
Q

FNH

A

Glutamine synthetase - map like +

20
Q

Breast myofibroblastoma

A

CD34+
SMA, Desmin +
Hormone receptors +
B catenin -

21
Q

Acinar cell carcinoma pancreas

A

BCL10+
Trypsin +
Chymotrypsin +
PASD + granules

22
Q

pancreatoblastoma

A

Acinar areas: PASD + granules, enzymes +, BCL10+
Squamoid nests: EMA +, B catenin +
Also neuroendocrine component

23
Q

Endometrial stromal sarc

A

CD10 + (50%, more so in low grade, but can be + in LMS)
Cyclin D1 (more so in high grade)
Desmin can be focal +

24
Q

Low grade ESS

A

JAZF1

25
Q

High grade ESS

A

YWHAE, BCOR others

26
Q

DCIS

A

ER strong diffuse

CK5/6 negative

27
Q

Adrenal cortex

A

Inhibin, melan A, BCL2 +
Weak synaptophysin +
Chromogranin +
SF1 best screening IHC?

28
Q

Medullary Thyroid Ca

A

TTF1, chromogranin, Synaptophyin, CK, CD56, calcitonin +

Thyroglobulin -

29
Q

Adenoid cystic carcinoma

A

CD117+ myoepithelial cells

Cyclin D1 + ??

30
Q

Pulmonary pneumocytoma

A

TTF1 + epithelium and storm

CK + epithelium only

31
Q

Lung mucinous adenocarcinnoma

A

Usually TTF1-
Often CK20+ as well as CK7+
Can’t rely on IHC to differentiate site of origin

32
Q

Thymoma

A

p63+
Pax8+
CD3+ T cells

33
Q

Thymic carcinoma

A

CD117+

Looks like various types of carcinoma

34
Q

dVIN

A

High grade by definition

p53 null or strong diffuse + in basal cells (lower 1/3)

35
Q

Chondroblastoma

A

H3.3 K36M + in mononuclear cells

36
Q

GCT of bone

A

H3F3 G34W

37
Q

Chordoma

A

CK +
S100+
Brachyury +

38
Q

Ewing sarcoma

A

CD99 + membranous
FLI1+ nuclear
NKX2.2 +
Tdt-

39
Q

Spindle cell lesions of the breast

A

Myofibroblastoma - CD34+, Desmin+, ER/PR/AR+
PT - CD34+
Spindle Ca - CK5/6
Also, pASH, scar

40
Q

Oncocytic renal neoplasms

A

Chromophobe: CK7+, Hales+, CD117+
Oncocytoma: CK7-, Hales -, CD117+
CCRCC: CK7-, Hales-, CD10+, CD117-

41
Q

Solid pseudopapillary neoplasm

A 
PASD+ globules
Nuclear beta catenin
CD10+ cytoplasmic
ECAD loss
ER+
SYN can be + but chromo -
42
Q

Ependymoma

A 
Olig2 -
Sox10 - 
GFAP +
EMA + dot like
H3K27ME3 - loss signifies type A
43
Q

Meningioma

A

SSRT1

Pathology (3 decks)

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